The divalent metal transporter (DMT1) is a 12-transmem-brane domain protein responsible for dietary iron uptake in
the duodenum and iron acquisition from transferrin in
peripheral tissues. The transmembrane domain 4 (TM4)
of DMT1 has been shown to be crucial for its biological
function. Here we report the 3D structure and topology of
the DMT1-TM4 peptide by NMR spectroscopy with
simulated annealing calculations in membrane-mimetic
environments, e.g. 2,2,2-trifluoroethanol and SDS micelles.
http://www.nap.edu/catalog/4886.html We ship printed books within 1 business day; personal PDFs are available immediately.
Mathematical Challenges from Theoretical/Computational Chemistry Committee on Mathematical Challenges from Computational Chemistry, National Research Council ISBN: 0-309-56064-0, 144 pages, 8.5 x 11, (1995) This PDF is available from the National Academies Press at: http://www.nap.edu/catalog/4886.
Endocrine disruptors function by: (i) Mimicking the action of a
naturally-produced hormone, such as estrogen or testosterone,
thereby setting off similar chemical reactions in the body; (ii)
Blocking hormone receptors in cells, thereby preventing the action
of normal hormones; or (iii) Affecting the synthesis, transport,
metabolism and excretion of hormones, thus altering the
concentrations of natural hormones.
Using chemical ionization mass spectrometry and photo-
acoustic spectroscopy, we analysed the evolution of vola-
tile organic compounds (VOCs) and other trace gases dur-
ing an approximately one-week measurement period each
in a pigsty and a sheep shed at the Federal Agricultural
Research Centre (FAL) in Mariensee, Germany. When ac-
tivities in the sheep shed were most intense during feeding
hours and manure removal, concentration surges of VOCs
were observed, which strongly correlated with methane
and ammonia levels.
Human health can be affected by acute or chronic
exposure to toxicants, through the media of water, wet
land sediments, or even air when sediments becom
dessicated and airborne or burnt. The nature of thes
exposures is exacerbated by human behaviours and
activities and they can result whenever ecosystem
services have been eroded – especially when the
hydrological services that maintain biological, geo
logical and chemical processes have been distorted
by human activities of over extraction of water.
Crystallins are the major proteins of a mammalian eye lens. The topologic-ally similar eye lens proteins,b- and c-crystallins, are the prototype and
founding members of the bc-crystallin superfamily. bc-Crystallins have
until recently been regarded as structural proteins. However, the calcium-binding properties of a few members and the potential role ofbc-crystallins
in fertility are being investigated.
Homology modeling in combination with transmembrane
topology predictions are used to build the atomic model of
Neurospora crassaplasmamembrane H
-ATPase, using as
template the 2.6 A
crystal structure of rabbit sarcoplasmic
-ATPase [Toyoshima, C., Nakasako, M.,
Nomura, H. & Ogawa, H. (2000)Nature405, 647–655].
A catalytic turnover of supercoiled DNA (scDNA) transformation medi-ated by topoisomerases leads to changes in the linking number (Lk) of the
polymeric substrate by 1 or 2 per cycle. As a substrate of the topoisomeri-zation reaction it is chemically identical to its product; even a single
catalytic event results in the quantum leap in the scDNA topology.