Chemotherapeutic agents

Xem 1-20 trên 41 kết quả Chemotherapeutic agents
  • As a scientist who has worked for more than 40 years to find cures for infectious disease, I find the idea that terrorists would use biological agents as a weapon to be anathema. It violates the fundamental values of the life sciences that I and my colleagues hold dear: that science is a vital tool for improving life and the health of our planet and enhancing our understanding of the natural world. My own work has focused on cholera, a disease responsible for the death of thousands of people around the world every year.

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  • Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo...

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  • Ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. Advanced ovarian cancers are difficult to cure with the current available chemotherapy, which has many associated systemic side effects. Doxorubicin is one such chemotherapeutic agent that can cause cardiotoxicity. Novel methods of delivering chemotherapy without significant side effects are therefore of critical need.

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  • Supervisory oversight of the S&L industry was both decentralized and split from the examination function. The FHLBB designated each regional Federal Home Loan Bank president as the Principal Supervisory Agent (PSA) for that region; senior Bank staff acted as supervisory agents. However, field examiners reported to the FHLBB in Washington rather than to the regional PSA, and the regional PSAeffectively reported to no one. In fact, according to one insider, the regional Federal Home Loan Banks “operated like indepen- dent duchies.

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  • In general, the health status at old age has an important individual and social relevance. The vulnerability is increasing by physiological and morphological changes in the organism and central nervous system during the ageing process. The indicators of physiological health are based on prevalence of disabilities and causes of death. In Germany the main causes of death are circulatory diseases, neoplasms, diseases of respiratory system and diseases of digestive system (Statistisches Bundesamt 2007a; Nolte, Shkolinikov & McKee 2000).

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  • The share of infrastructure increased to 40 percent in 2011 from 31 percent in 2010 while the share of industry decreased to 32 percent––though given the substantial increase in BNDES lending, the absolute levels of credit for industry have increased. (see Figure 19). Looking further ahead, BNDES could gradually shift toward promoting the development of long-term capital markets, including by playing a role in standardization and market making (e.g., co-financing of infrastructure projects with the private sectors) in the long-term financing market. ...

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  • In the first section of this book, ‘Retroviral Vector’, chapter one discusses the efficiency of retroviral DNA integration, the preferences of integration for certain regions, and advances on integration site selection and gene therapy. Chapter two reviews and discusses the current cell lines and bioreaction platforms used for production of retroviral and lentiviral vectors, focusing on the current bottlenecks and future directions with a particular emphasis in the metabolic constrains.

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  • Why, then, have scores of drugs, previously found to be effective in animal models, failed clinical trials? The average clinician will answer this question by saying that animal experiments are useless, that they do not reflect the human situation, that they are badly designed and carried out, and so forth. Meetings and committees have even been celebrated to declare this truth, and to teach preclinical neuroscientists how to properly carry out their experiments, see for example the “STAIR” (Stroke Therapy Academic Industry Roundtable) meetings in the US....

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  • A public pension fund’s decision to invest in emerging domestic markets is driven first and foremost by its fiduciary duty and overarching mission to achieve competitive financial returns for its pension fund retirees and beneficiaries. Public pension funds, as with any institutional fund, seek to outperform the market. Investments targeted to EDM can both achieve good returns and help overall fund performance by diversifying the pension fund’s portfolio. A well-diversified portfolio is made up of a spectrum of asset classes as a means of spreading risk across classes.

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  • The second phase of this financial crisis is less uncommon except that the severity of the macroeconomic downturn confronting countries around the world is the worst since the Great Depression of the 1930s. The financial crisis soon spread to real sectors to negatively affect whole economies, production, firms, investors, and households. Many of these countries, particularly those with emerging and developing markets, have been pulled down by the ever widening flight of capital from their economies and by falling exports and commodity prices.

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  • Onychomadesis Onychomadesis is caused by temporary arrest of nail matrix mitotic activity. Common drugs reported to induce onychomadesis include carbamazepine, lithium, retinoids, and chemotherapeutic agents such as cyclophosphamide and vincristine. Paronychia Paronychia and multiple pyogenic granuloma with progressive and painful periungual abscess of fingers and toes are a side effect of systemic retinoids, lamivudine, indinavir, and anti-EGFR monoclonal antibodies (cetuximab, gefitinib).

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  • Cancer Cell Biology The treatment of most human cancers with conventional cytoreductive agents has been unsuccessful due to the Gompertzian-like growth kinetics of solid tumors (i.e., tumor growth is exponential in small tumors, with increasing doubling times as tumors expand; since conventional chemotherapeutic agents target proliferating cells, noncycling cells in large tumors are relatively resistant). Genetic instability is inherent in most cancer cells and predisposes to the development of intrinsic and acquired drug resistance. Thus, although tumors arise from a single cell (i.e.

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  • Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life‐long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and barley). The toxicity of gluten is manifested by the autoimmune action of T‐lymphocytes on mucosal cells in the small intestine, disrupting its vital function of absorbing nutrients from food.

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  • Based upon the most recent studies, it is now apparent that ozone plays an important role in causing acute health effects, such as heightening asthma symptoms and developing bronchitis symptoms. The role of ozone in producing long-term or chronic effects is less clear, at least from the available epidemiological studies. However, laboratory animal studies suggest that there can be long-term consequences. How to Reduce Ozone Exposure The U.S. Environmental Protection Agency (EPA) has recommended that ozone should not exceed 0.08 ppm averaged over an 8-hr period.

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  • Federal and state governments have largely failed in their attempts to lower the cost of health insurance or even slow its rate of growth. The hotly debated Patient Protection and Affordable Care Act (PPACA), commonly called Obamacare, was signed into law in March 2010, and was the most aggressive effort to reform the healthcare system ever. But as with most health reform efforts, it failed to address the fundamental causes of rising healthcare costs while opting to focus on coverage.

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  • The explosive development of networked electronic mail (email) has been one of the major technical and sociological developments of the past 40 years. A number of authors have already looked at the development of email from various perspectives.1 The goal of this article is to explore a perspective that, surprisingly, has not been thoroughly examined: namely, how the details of the technology that implements email in the Internet have evolved. This is a detailed history of email’s plumbing. One might imagine, therefore, that it is only of interest to a plumber.

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  • The current production of rubber is 2.87 million tonnes per year and export is 2.57 million tonnes per year. The remnants are domestically used. The important trading partners of Thailand are China, Japan, Malaysia and USA. The rubber price during 1999-2003 gradually decreased from 1998 until 2000. The government had to interfere in the mid-2000. However, the rubber price has been increasing since the end of 2000 due to the world demand and expansion of world economy. The rubber plantation industry is dominated by the small holding sector accounting for 95% in terms of area.

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  • Species mixtures are often recommended over single- species cover crops or sod crops because the mixtures tend to use resources more fully and provide a more diverse habitat. Except in situations where a legume would not establish well, or where the nitrogen-fixing power of legumes is not desired, at least one legume and one non-legume are recom- mended. Some growers establish a sod-forming crop between rows of a cash crop, forming a living mulch which provides soil-improving benefits without taking land totally out of vegetable production.

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  • OTHER CAUSES Side effects from medications are probably the most common noninfectious cause of acute diarrhea, and etiology may be suggested by a temporal association between use and symptom onset. Although innumerable medications may produce diarrhea, some of the more frequently incriminated include antibiotics, cardiac antidysrhythmics, antihypertensives, nonsteroidal anti-inflammatory drugs (NSAIDs), certain antidepressants, chemotherapeutic agents, bronchodilators, antacids, and laxatives.

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  • Karnofsky was among the first to champion the evaluation of a chemotherapeutic agent's benefit by carefully quantitating its effect on tumor size and using these measurements to objectively decide the basis for further treatment of a particular patient or further clinical evaluation of a drug's potential.

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