As an editor for Fitness magazine, my job is to be a conduit of information between
my readers and the experts (registered dietitians, medical doctors, and researchers). In
essence, I’m a translator. You see, most experts speak what I like to call medicalese—a
complex, exceedingly tedious language that few outside their professions can understand.
Medicalese words can be as long as some sentences, sentences are usually the
size of paragraphs, and whole studies—well, let’s just say it takes a lot of coffee to get
through some of them....
Your blood cholesterol level has a lot to do with
your chances of getting heart disease. High blood
cholesterol is one of the major risk factors for heart
disease. A risk factor is a condition that increases
your chance of getting a disease. In fact, the higher
your blood cholesterol level, the greater your risk
for developing heart disease or having a heart
attack. Heart disease is the number one killer of
women and men in the United States. Each year,
more than a million Americans have heart attacks,
and about a half million people die from heart
There are a number of well-recognized indicators of biological risk for cardiovascular
disease, diabetes, and death for which change over some period of
time can be determined from the U.S. National Health and Nutrition Examination
Surveys (NHANES). Collection of some measures began as early as the 1960s,
and some are not available until the 1980s. NHANES data show that the percentage
of the older population with high cholesterol has decreased since the 1960s,
somewhat faster for women than men (60).
Hemolytic Anemias Due to Abnormalities of the MembraneCytoskeleton Complex
The detailed architecture of the red cell membrane is complex, but its basic design is relatively simple (Fig. 101-2). The lipid bilayer, which incorporates phospholipids and cholesterol, is spanned by a number of proteins that have their hydrophobic transmembrane domains embedded in the membrane. Most of these proteins have hydrophilic domains extending toward both the outside and the inside of the cell.
The multidrug resistance-associated protein transporter ABCC1 (MRP1) is
an integral plasma membrane protein involved in the multidrug resistance
phenotype. It actively expels a number of cytotoxic molecules from cells.
To gain insight into the modulation of the functional properties of this
integral membrane protein by cholesterol, a main component of the lipid
bilayer, we used multidrug-resistant GLC4⁄ADR cells,
Serum total Cholesterol (CHO), HDL-cholesterol (HDL-C), Triglycerid (TG) were measured on 58 normal subjects (control) and 77 gouty patients at HTO. Our results showed that: The number of young patients in our report was rather higher than those found in previous reports (27.27 % of the patients with age less than 40). Patients had significantly higher cholesterol, triglycerid, the CHO/HDL-C ratio and lower HDL than control group. Hyperlipemia was the most commun accompaning abnormal laboratory test (84.41%). The prevalence of high triglycerid on gouty patients was 79.21%. ...
Proprotein convertase subtilisin⁄kexin type 9 (PCSK9) is a secreted protein
that regulates the number of cell surface low-density lipoprotein receptors
(LDLRs) and the levels of low-density lipoprotein cholesterol in plasma.
Because death rate increases with age, stroke mortality is highest among elderly women. In 2005
the death rate from stroke for women over 65 varied from highs of 1,276.55/100,000 in Latvia and
874.43/100,000 in Lithuania to lows of 218.44/100,000 in France and 297/100,000 in Iceland (WHO
There are a number of known risk factors for cardiovascular diseases in women.