Understanding the biological basis of aging has fascinated people throughout
recorded history, and is one of the great remaining scientific questions. The question
has never been more important than now, as we anticipate the impact that a
rapidly growing older population will have on the social, political, and medical
landscape over the next 50 years. There is increasing evidence that aging involves
damage to the genome, and it is certainly the case that such damage explains much
of the coupling of most cancers to aging.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells
Genetic information is physically carried on large DNA strings that are organized into
chromosomes. Each species is characterized by a chromosome set that carry the
information necessary and sufficient for its development and survival. Eukaryotic
organisms are mostly diploid, containing two sets of chromosomes with each pair
carrying nearly identical genetic information. Occasionally, exceptions to this rule are
found, such as haploid yeast (with only one set of chromosomes) or polyploid ferns
and frogs (with multiple sets).
Chromosomal Instability in Solid Tumors Solid tumors are generally highly aneuploid, containing an abnormal number of chromosomes; these chromosomes also exhibit structural alterations such as translocations, deletions, and amplifications. Again, colon cancer has proven to be a particularly useful model for the study of chromosomal instability (CIN). As described above, some familial cases are characterized by the presence of MIN.