Chronic Myelogenous Leukemia: Treatment
The therapy of CML is changing rapidly because we have a proven curative treatment (allogeneic transplantation) that has significant toxicity and a new targeted treatment (imatinib) with excellent outcome based on 5-year follow-up data. Therefore, physician experience and patient preference must be factored into the treatment selection process. Discussion of both treatment options with a patient is indicated. The decision should focus on the outcomes, risks, and toxicities of the various approaches.
Chronic Myelogenous Leukemia
Incidence The incidence of chronic myelogenous leukemia (CML) is 1.5 per 100,000 people per year, and the age-adjusted incidence is higher in men than in women (2.0 versus 1.2). The incidence of CML increases slowly with age until the middle forties, when it starts to rise rapidly. CML incidence for males decreased slightly (4.4%) between 1997 and 2003 as compared to 1977–1997.
The diagnosis of CML is established by identifying a clonal expansion of a hematopoietic stem cell possessing a reciprocal translocation between
chromosomes 9 and 22.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Gender and ethnic differences in chronic myelogenous leukemia prognosis and treatment response: a single-institution retrospective study
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report...
Bài giảng Những rối loạn tăng sinh tủy (Myeloproliferative neoplasms) trình bày những nội dung chính như: Bạch cầu mạn dòng tủy (chronic myelogenous leukemia: CML), đa hồng cầu nguyên phát (Polycythemia vera: PV), tăng tiểu cầu nguyên phát (Essential thrombocythemia: ET), tăng tiểu cầu nguyên phát (Essential thrombocythemia: ET). Mời các bạn cùng tham khảo.
The preparation of human
karyotype for the first time in 1959 led to the identification of numerical aberrations in
the following years associated with Down’s, Turner and Klinefelter syndromes which
implied the need for routine screening for chromosomal anomalies in certain clinical
Learners enrolled in all healthcare training programs need to have a basic understanding
of medical genetics so that they can successfully transition from students to clinicians.
The field of medical genetics is advancing at a fast pace and is becoming increasingly integral
to all aspects of medicine. This fact emphasizes the need for every practicing clinician
and faculty member to develop an in-depth knowledge of the principles of human genetics,
given that they are applicable to such a wide variety of clinical presentations.
The differential diagnostic possibilities are much fewer when the spleen is "massively enlarged," palpable more than 8 cm below the left costal margin or its drained weight is ≥1000 g (Table 60-3). The vast majority of such patients will have non-Hodgkin's lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, chronic myelogenous leukemia, myelofibrosis with myeloid metaplasia, or polycythemia vera.