Xem 1-20 trên 87 kết quả Clinical pathway
  • Five years have passed since the first edition of Principles of Clinical Pharmacology was published. The second edition remains focused on the principles underlying the clinical use and contemporary development of pharmaceuticals. However, recent advances in the areas of pharmacogenetics, membrane transport, and biotechnology and in our understanding of the pathways of drug metabolism, mechanisms of enzyme induction, and adverse drug reactions have warranted the preparation of this new edition.

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  • Other Organ Systems and the Future The use of stem cells in regenerative medicine has been studied for many other organ systems and cell types, including skin, eye, cartilage, bone, kidney, lung, endometrium, vascular endothelium, smooth muscle, striated muscle, and others. In fact, the potential for stem cell regeneration of damaged organs and tissues is virtually limitless. However, numerous obstacles must be overcome before stem cell therapies can become a widespread clinical reality.

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  • PATHWAY #4 DIABETIC FOOT DISORDERS VOLUME 45, NUMBER 5, SEPTEMBER/OCTOBER 2006 S–29 be present. Hospitalization is required to treat the infection as well as systemic sequelae. Patients with poor vascular status and ischemia have an increased potential for amputation and require prompt consultation for potential revascularization (30, 77, 200). In 2004, the Infectious Disease Society of America (IDSA) developed new guidelines for the diagnosis and treatment of diabetic foot infections (123).

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  • Multiple Variants Modulating Drug Effects As this discussion makes clear, for each drug with a defined mechanism of action and disposition pathways, a set of "candidate genes," in which polymorphisms may mediate variable clinical responses, can be identified. Indeed, polymorphisms in multiple genes have been associated with variability in the effect of a single drug. CYP2C9 loss-of-function variants are associated with a requirement for lower maintenance doses of the vitamin K antagonist anticoagulant warfarin. In rarer (...

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  • Psychiatric disorders represent a complex interaction between psychological, developmental, neurobiological, and genetic factors. This book focuses on the neurobiological elements of psychiatric conditions. In the last 30 years, much has been learned about the neuroanatomic, neurophysiological, neurochemical, and molecular elements that contribute to major psychiatric illnesses such as schizophrenia, drug dependence, anxiety disorders, major depression, bipolar disorder, and dementias.

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  • he Second Edition of this single-authored volume integrates multiple disciplines of basic and clinical research to help clinicians further develop the best possible care for the rehabilitation of patients with neurologic diseases. From the readable descriptions of the structures and functions of pathways for movement and cognition, the reader comes to understand the potential for training induced, pharmacologic,

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  • Neurologic Evaluation Peripheral sensory neuropathy is the major risk factor for diabetic foot ulceration (24, 26, 27, 46, 50). The patient history and physical examination utilizing the 5.07 SemmesWeinstein monofilament (10-g) wire are sufficient to identify individuals at risk for ulceration (26, 232-235). Vibration perception threshold assessment with the biothesiometer is also useful in identifying patients at high risk for ulceration (44, 57, 236). More sophisticated studies such as nerve conduction studies are rarely necessary to diagnose peripheral sensory neuropathy.

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  • Descriptors for these considerations (62, 290, 291). For example, the University of Texas San Antonio (UTSA) system (Table 6) associates lesion depth with both ischemia and infection (290). This system has been validated and is generally predictive of outcome, since increasing grade and stage of wounds are less likely to heal without revascularization or amputation (290, 293). The UTSA system is now widely used in many clinical trials and diabetic foot centers.

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  • Interleukin (IL)-6-type cytokines exert their effects through activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade. The JAK/STAT pathways play an important role in rheumatoid arthritis, since JAK inhibitors have exhibited dramatic effects on rheumatoid arthritis (RA) in clinical trials. In this study, we investigated the molecular effects of a small molecule JAK inhibitor, CP690,550 on the JAK/STAT signaling pathways and examined the role of JAK kinases in rheumatoid synovitis....

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  • (BQ) Part 1 book "Textbook of biochemistry with clinical correlations" presents the following contents: Eukaryotic cell structure, composition and structure, structure—function relationships in protein families, classification, kinetics and control, structure and membrane transport, bioenergetics and oxidative metabolism, major metabolic pathways and their control.

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  • Chapter 28 - The lymphatic and immune systems. After completing chapter 28, you will be able to: List the pathways and organs of the lymphatic system and give their locations; define lymph and tell how it is circulated in the body; define the terms infection, pathogen, and antigen; list and describe the nonspecific body defense mechanisms; explain the signs and causes of inflammation.

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  • Chapter 31 - The digestive system. After completing chapter 31, you will be able to: List the functions of the digestive system; trace the pathway of food through the alimentary canal; describe the structure and functions of the mouth, teeth, tongue, and salivary glands; describe the structure and function of the pharynx; describe the swallowing process;...

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  • Chapter 28 - The lymphatic and immune systems. After completing chapter 28, you will be able to: List the pathways and organs of the lymphatic system and give their locations; define lymph and tell how it is circulated in the body; define the terms infection, pathogen, and antigen; list and describe the nonspecific body defense mechanisms; explain the signs and causes of inflammation;...

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  • Chapter 29 - The digestive system. After completing chapter 29, you will be able to: List the functions of the digestive system; trace the pathway of food through the alimentary canal; describe the structure and functions of the mouth, teeth, tongue, and salivary glands; describe the structure and function of the pharynx; describe the swallowing process;...

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  • Emergencies in medicine are difficult on two fronts: they may challenge both the health of the patient and the skills of the doctor in charge. If the latter, the former may deteriorate rapidly. Thus, the definition of an emergency indeed depends on who is facing it. As we mature along our clinical pathways of education, training, and experience, the risk of going through a personal professional emergency is continuously reduced. Nevertheless, throughout our medical career, accurate self-assessment and subsequent control of our actions remain our most important qualities.

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  • Several new aspects have been highlighted: for example, a novel role for lipids as receptors which drive protein sorting, the diversity of the sorting events that occur at the level of the Golgi apparatus, and the cross talk between exocytosis and autophagy. Moreover, an interesting example of how the knowledge of these pathways is exploited to generate novel secretory routes to direct the synthesis of bio-molecules in “cell factories” is discussed.

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  • Improved Outcomes in Colon and Rectal Surgery part 1. Written by many of the worlds leading colorectal surgeons, this evidence-based text investigates the risks and benefits of colorectal surgeries. By using clinical pathways, algorithms, and case discussions, the authors identify the best practices for patient safety and positive outcomes to ensure that physicians correctly recognize potential problems and carefully manage complications

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  • Improved Outcomes in Colon and Rectal Surgery part 2. Written by many of the worlds leading colorectal surgeons, this evidence-based text investigates the risks and benefits of colorectal surgeries. By using clinical pathways, algorithms, and case discussions, the authors identify the best practices for patient safety and positive outcomes to ensure that physicians correctly recognize potential problems and carefully manage complications

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  • Improved Outcomes in Colon and Rectal Surgery part 3. Written by many of the worlds leading colorectal surgeons, this evidence-based text investigates the risks and benefits of colorectal surgeries. By using clinical pathways, algorithms, and case discussions, the authors identify the best practices for patient safety and positive outcomes to ensure that physicians correctly recognize potential problems and carefully manage complications

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  • Improved Outcomes in Colon and Rectal Surgery part 4. Written by many of the worlds leading colorectal surgeons, this evidence-based text investigates the risks and benefits of colorectal surgeries. By using clinical pathways, algorithms, and case discussions, the authors identify the best practices for patient safety and positive outcomes to ensure that physicians correctly recognize potential problems and carefully manage complications

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