Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lymph node metastasis in grossly apparent clinical stage Ia epithelial ovarian cancer: Hacettepe experience and review of literature
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Use of WHO clinical stage for assessing patient eligibility to antiretroviral therapy in a routine health service setting in Jinja, Uganda...
Biomarkers are the keystone of stratified medicine. Now, as for any new medical product,
the development of bioassays follows a pathway that begins with basic research and moves
toward preclinical and clinical stages. Although biomarkers can be identified in clinical
phases, the discovery of new biomarkers is often ground in knowledge generated by
academic basic research. A better understanding of disease mechanisms is crucial in this
Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. ...
Renal Disease Renal excretion of parent drug and metabolites is generally accomplished by glomerular filtration and by specific drug transporters, only now being identified. If a drug or its metabolites are primarily excreted through the kidneys and increased drug levels are associated with adverse effects, drug dosages must be reduced in patients with renal dysfunction to avoid toxicity. The antiarrhythmics dofetilide and sotalol undergo predominant renal excretion and carry a risk of QT prolongation and arrhythmias if doses are not reduced in renal disease.
Bronchogenic carcinoma can mimic or be masked by pulmonary
tuberculosis (TB), and the aim of this study was to describe the radiologic findings
and clinical significance of bronchogenic carcinoma and pulmonary TB which
coexist in the same lobe.
Materials and Methods: The findings of 51 patients (48 males and three
females, aged 48-79 years) in whom pulmonary TB and bronchogenic carcinoma
coexisted in the same lobe were analyzed.
Consensus is always difficult. Even in the setting of level I evidence, competing
interpretations, experiences and interests present challenges to the best-intentioned analyses.
Consensus requires commitment to the process, time, a spirit of collaboration and, above all,
For many, Andy Novick’s career was both the quintessence of leadership and the
embodiment of the best in academic urology.
Chapter 13 - Patient reception area. This chapter describes the patient reception area. As you look at the reception area and patient bathrooms through the eyes of patient needs, you begin to see ways to make the rooms both inviting and functional. Additionally, you will learn about the special needs of disabled patients. Well-planned and pleasant surroundings can do much to set the stage for a successful interaction between the patient and the doctor and other medical staff.
Chapter - Communication with patients, families, and coworkers. Identify elements of the communication circle, understand and define the developmental stages of the life cycle, give examples of positive and negative communication, list ways to improve listening and interpersonal skills,...
Specific micronutrient deficiencies may affect maternal and foetal health. Iodine deficiency
during pregnancy may cause foetal brain damage and mental retardation in infants. Vitamin
A deficiency increases the risk in pregnant women of infection and anaemia, may cause
blindness during pregnancy and early lactation, and has been associated to an elevated risk of
HIV mother-to-child transmission. Folate deficiency may cause severe foetal neural tube
defects like anencephaly and spina bifida.
The combination of functional metabolic information and
anatomical data has been available since 2001, when the combined
PET/CT scanner was introduced. This technology has had
a significant impact on many medical disciplines, including cardiology
and neurology, but undoubtedly the greatest impact has
been in the field of oncological imaging. It is the ability of
PET/CT to accurately identify the anatomical location of abnormal
metabolic activity that has revolutionized the detection and
staging of many tumors....
The head and neck is a region of considerable anatomical and functional complexity,
making the accurate staging of a head and neck neoplasm a challenging task. The clinician
often detects pathology, but may not appreciate, based on the physical examination, the
entire submucosal tumor extension, nor the possible regional and distant disease spread.
The introduction of CT and MRI has revolutionized head and neck radiology. Current
radiological modalities provide a reliable visualization of the head and neck structures to
an unprecedented level of detail.
The most important prognostic factor is the stage at the time of presentation. Fortunately, most melanomas are diagnosed in clinical stages I and II. The revised American Joint Committee on Cancer (AJCC) staging system for melanoma is based on microscopic primary tumor depth (Breslow's thickness), presence of ulceration, evidence of nodal involvement, and presence of metastatic disease to internal sites (Table 83-3). Certain anatomic sites may affect the prognosis.
Neither randomized clinical trials nor meta-
analysis are available and evidence is based on a number of retrospective studies with
multivariate for mortality risk factors or data from national cancer registries (Gilliland et al.,
1997; Hundahl et al., 1998). Unfortunately, very remarkable differences in patient’s selection,
staging systems, and clinical management affect the available studies. In particular,
radioiodine treatment is not routinely carried out in a standard manner and outcome results
of different studies are thus not comparable (Sciuto et al., 2009).
Hepatocellular carcinoma (HCC) used to be regarded as a rare disease.
The increasing numbers of chronic hepatitis C virus carriers in the United
States and subsequent increased incidence of HCC seen in most large
medical centers means that it is no longer an uncommon disease for most
gastroenterologists or oncologists to encounter.
During the times when liver resection or systemic chemotherapy were
the only real therapeutic modalities available, the outcomes were generally
dismal, especially because most patients presented with advanced-stage
The scope of practice of the gynecologist is broad and challenging. The
gynecologist is blessed with the longitudinal care of women from adolescence
through the end stages of life. In fact, many women consider their
gynecologist their primary care physician.
This edition of Obstetrics and Gynecology Clinics of North America
explores many of the daily challenges of office practice. Updates in new
contraceptive options and in management of dysfunctional uterine bleeding
Between December 2003 and December 2007, a total of 222 radical transurethral resection of
prostate cancer were performed under spinal anesthesia in 170 patients with clinical stages
of T1 or T2. Clinical stages were determined according to the UICC TNM staging system of
1997. We informed the patients that the procedure was not a current standard radical
method of management, and those who refused this procedure were excluded from the
study. We also excluded patients with serious comorbidities that might affect their lives by
The governor’s office has expressed the view that, since Planned Parenthood affiliates
constitute just 2% of WHP providers, patients would have little difficulty finding alternative
providers. Our analysis indicates that in the markets they serve, Planned Parenthood affiliates
serve half, and sometimes much more than half, of all WHP patients.