Clinical trial programs

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  • Clinical trials enable scientific discoveries to advance patient care, and they also inform and guide subsequent research. The National Cancer Institute (NCI) supports the largest U.S. network of clinical trials of any type, of which the largest component is the Clinical Trials Cooperative Group Program (informally known as the Cooperative Group Program). It currently comprises 10 Groups that involve more than 3,100 institutions and 14,000 investigators who enroll more than 25,000 patients in clinical trials each year.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Amount of health care and self-care following a randomized clinical trial comparing flexion-distraction with exercise program for chronic low back pain...

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  • Pathfinder International works with communities at the grassroots level to expand access and knowledge, stimulate acceptance, and create awareness and ownership of RH/FP services. Pathfinder has been implementing community-based programs since 1979, when it began the first community-based distribution of family planning information and commodities in Bangladesh and Kenya. In the 1980s and ’90s, Pathfinder initiated the first community-based services in Azerbaijan, Côte d’Ivoire, Jordan, Kazakhstan, Senegal, Tanzania, and Uganda.

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  • The perfect cardiac catheterization technique, including good diagnostic and therapeutic qualities, without risk and with no recovery time for the patient, does not exist. Obtaining initial access to the arterial circulation is the first and most frequent catheterization difficulty encountered by the interventional cardiologist during the procedure. Often, it is also the only difficult part of the exam for the patient because it may cause a vagal reaction or painful spasm.

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  • Mark W Smith*1,2 and Paul G Barnett1,2,3 Address: 1Health Economics Resource Center, US Department of Veterans Affairs, Menlo Park, California, USA, 2Center for Primary Care and Outcomes Research, Stanford University School of Medicine, Palo Alto, California, USA and 3Department of Health Research and Policy, Stanford University School of Medicine, Palo Alto, California, USA Email: Mark W Smith* - mark.smith9@va.gov; Paul G Barnett - paul.barnett@va.gov * Corresponding author Published: 22 April 2008 Implementation Science 2008, 3:20 doi:10.

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  • An intensive weight loss program in Slovenia including behavioral, psychological, cognitive and physical ele- ments has shown promising long-term results on 48 sub- jects [21]. Median weight loss of completers when they left the program was 11.5 kg. At least 5 years later, 13 of them still maintained the reduced weight. It is important to note that only participants who had successfully completed at least 4 months of treatment were included in the analysis.

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  • Reduced levels of clinical or radiological pneumonia in clin- ical trials of a nine-valent pneumococcal conjugate vaccine provide an estimate of the vaccine-preventable disease burden (valency indicates the number of serotypes against which the vaccine provides protection; conjugate refers to conjugation of polysaccharides to a protein backbone). In a study in The Gambia, 37 percent of radiological pneumonia was prevented, reflecting the amount of disease caused by S. pneumoniae, and mortality was reduced by 16 percent (Cutts and others 2005).

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  • Respiratory distress is a common symptom of patients transported to hospitals by emergency medical services (EMS) personnel. The benefit of advanced life support for such patients has not been established. METHODS The Ontario Prehospital Advanced Life Support (OPALS) Study was a controlled clinical trial that was conducted in 15 cities before and after the implementation of a program to provide advanced life support for patients with out-of-hospital respiratory distress.

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  • Although women account for more physician office visits than men, most women receive diagnoses and treatments based on what has worked for men. Until recently, medical research has largely ignored many health issues important to women, and women have long been under-represented in clinical trials. Many health education programs have realized this inequity and have begun to incorporate women’s health programs into their curriculum.

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  • With current techniques, the risk of graft rejection is 1–3%, and the risk of severe, life-threatening acute GVHD is ~15% following transplantation between HLA-identical siblings. The incidence of graft rejection and GVHD increases progressively with the use of family member donors mismatched for one, two, or three antigens. While survival following a one-antigen mismatched transplant is not markedly altered, survival following two- or three-antigen mismatched transplants is significantly reduced, and such transplants should be performed only as part of clinical trials.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical evidence continuous medical education: a randomised educational trial of an open access e-learning program for transferring evidence-based information – ICEKUBE (Italian Clinical Evidence

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  • Investigators continue to evaluate screening technologies in meta-analyses, randomized clinical trials, and cervical cancer prevention programs. The new evidence adds support for the use of HPV DNA testing as the primary technology for cervical cancer screening, both in high-resource areas and in developing countries. 6–8 Despite this evidence, significant barriers to widespread use of HPV DNA testing stand in the way, both in high- and low-resource areas.

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  • The efficacy of a screen-and-treat program is influenced not only by accuracy of the screening test but also by the ability of the treatment, in this case cryotherapy, to eliminate CIN2+ lesions identified by screening. While cryotherapy was highly successful in this trial, eliminating 75 to 77 percent of CIN2+ lesions, this was lower than previously reported 85 to 90 percent cure rates for clinical trials in developed countries and for less rigorous studies in developing regions.

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  • Clinical evidence continuous medical education: a randomised educational trial of an open access e-learning program for transferring evidence-based information – ICEKUBE (Italian Clinical Evidence Knowledge Utilization Behaviour Evaluation) – study protocol Lorenzo Moja*1, Ivan Moschetti1, Michela Cinquini2, Valeria Sala1, Anna Compagnoni3, Piergiorgio Duca4, Christian Deligant5, Roberto Manfrini5, Luca Clivio6, Roberto Satolli5, Antonio Addis7, Jeremy M Grimshaw8, Pietro Dri5 and Alessandro Liberati1 Address: 1Italian Cochrane Centre, Mario Negri Institute for Pharmacological Researc...

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