Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:
Immunohistochemical identification of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal carcinoma: a case report...
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis
Adecrease in the level ofO-acetylatedsialicacidsobserved in
colorectal carcinoma may lead to an increase in the expres-sion of sialyl Lewis
, a tumor-associated antigen, which is
related toprogressionof colorectal cancer tometastasis. The
underlyingmechanism for this reduction is, however, not
fully understood. Two enzymes are thought to be primarily
responsible for the turnover of O-acetyl ester groups on
sialic acids; sialate-O-acetyltransferase (OAT) and sialate-O-acetylesterase (OAE).
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition...
To better understand the mechanism underlying colorectal carcinoma
(CRC) genesis or metastasis, and to search for potential markers for CRC
prognosis, a comparative proteomic analysis was performed on CRC tissue.
Proteins were extracted from normal colorectal mucosa, non-metastatic
CRC (nmCRC) and metastatic CRC (mCRC) tissue samples.
Gastric cancer is the second most common cause of cancer-related death in the world. There are no screening tests available for its diagnosis, therefore patients usually presents in late stages, associated with poor prognosis. Currently, many efforts are made toward new advances in the treatment strategies. The book makes an insight into the assessment of premalignant lesions, current management of early gastric cancer, risk and protective factors in gastric carcinogenesis.
The aim of this study was to uncover the membrane protein profile differ-ences between colorectal carcinoma and neighboring normal mucosa from
colorectal cancer patients. Information from cellular membrane proteomes
can be used not only to study the roles of membrane proteins in fundamen-tal biological processes, but also to discover novel targets for improving
the management of colorectal cancer patients.
Many of the introductory comments in the first edition of this book
regarding the increasingly focused approach required of pathologists to
surgical cancer histopathology reports still pertain. In the intervening
period a number of trends have continued to develop that have required
Trong vài năm qua, sự chữa trị trong oncology đã càng ngày càng đi sâu vào molocular biology. Trên thế giới, hiện nay đã bắt đầu có thuốc chống ung thư dựa theo lối này, chẳng hạn monoclonal antibodies chống lại epidermal growth factor receptor (EGFR) và vascular endothelial epidermal growth factor (VGEF). Tại HKỳ các thuốc này đang được dùng trong chiến tuyến thứ nhì hay thứ ba (second line or third line therapies) để chống ung thư đã chuyển di (metastatic colorectal carcinoma).
It is hard to find adrenal carcinomas early and they are often quite large when diagnosed.
Adrenal carcinomas are often found earlier in children than in adults because adrenal
cancers in children more commonly secrete hormones. Children will show outward signs
of excess hormone production early. For example they may develop very early signs of
puberty due to the sex hormones that sometimes are produced by adrenal cancer. In
adults, these tumors may be found early by accident, when a CT scan is done for some
other health concern.
In practice, signatures that predict toxicity or efficacy can be identified afterwards. For example,
therapies targeting the Epidermal Growth Factor Receptor have been first approved before it was
demonstrated that mutations in KRAS cancer gene were associated to failures of the relevant
therapies in metastatic colorectal carcinoma. This example shows that well-designed
retrospective analysis of data from prospective randomized controlled trials can bring forward
effective treatments to biomarker defined subgroups of patients in a timely manner.
Today, cancer research is focused on determining how genome and proteome level
information may be useful as tools in prevention, diagnosis, and prognosis. The
development of “omics” technologies, such as proteomics and transcriptomics has
opened new research areas for scientists working on cancer research.