Compartmental models

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  • This book provides an example of the successful and rapid expansion of bioengineering within the world of the science. It includes a core of studies on bioengineering technology applications so important that their progress is expected to improve both human health and ecosystem. These studies provide an important update on technology and achievements in molecular and cellular engineering as well as in the relatively new field of environmental bioengineering.

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  • This book provides an example of the successful and rapid expansion of bioengineering within the world of the science. It includes a core of studies on bioengineering technology applications so important that their progress is expected to improve both human health and ecosystem. These studies provide an important update on technology and achievements in molecular and cellular engineering as well as in the relatively new field of environmental bioengineering.

    pdf302p cucdai_1 19-10-2012 62 9   Download

  • THERMODYNAMIC MODELING, ENERGY EQUIPARTITION, AND NONCONSERVATION OF ENTROPY FOR DISCRETE-TIME DYNAMICAL SYSTEMS WASSIM M. HADDAD, QING HUI, SERGEY G. NERSESOV, AND VIJAYSEKHAR CHELLABOINA Received 19 November 2004 We develop thermodynamic models for discrete-time large-scale dynamical systems. Specifically, using compartmental dynamical system theory, we develop energy flow models possessing energy conservation, energy equipartition, temperature equipartition, and entropy nonconservation principles for discrete-time, large-scale dynamical systems.

    pdf44p sting12 10-03-2012 22 4   Download

  • Dipeptidyl peptidase IV (DPP IV, CD26, EC 3.4.14.5) serves as a model aimed at elucidating protein sorting signals. We identify here, by MS, sev-eral tyrosine-phosphorylated proteins in a rat liver Golgi⁄endosome (G⁄E) fraction including DPP IV. We show that a pool of DPP IV is tyrosine-phosphorylated.

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  • ON MONOTONICITY OF SOLUTIONS OF DISCRETE-TIME NONNEGATIVE AND COMPARTMENTAL DYNAMICAL SYSTEMS VIJAYSEKHAR CHELLABOINA, WASSIM M. HADDAD, JAMES M. BAILEY, AND JAYANTHY RAMAKRISHNAN Received 27 October 2003 Nonnegative and compartmental dynamical system models are widespread in biological, physiological, and pharmacological sciences. Since the state variables of these systems are typically masses or concentrations of a physical process, it is of interest to determine necessary and sufficient conditions under which the system states possess monotonic solutions.

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  • Cellular regulation is a result of complex interactions arising from DNA–protein and protein–protein binding, autoreg-ulation, and compartmentalization and shuttling of regula-tory proteins. Experiments in molecular biology have identified these mechanisms recruited by a regulatory net-work.Mathematicalmodelsmaybe used to complement the knowledge-base provided byin vitroexperimental methods. Interactions identified byin vitroexperiments can lead to the hypothesis of multiple candidate models explaining the in vivo mechanism. ...

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  • Using thein situ liver model system, we have recently shown that, after cholera toxin binding to hepatic cells, cholera toxin accumulates in a low-density endosomal compartment, and then undergoes endosomal proteoly-sis by the aspartic acid protease cathepsin-D [Merlen C, Fayol-Messaoudi D, Fabrega S, El Hage T, Servin A, Authier F (2005)FEBS J272, 4385– 4397]. Here, we have used a subcellular fractionation approach to address the in vivo compartmentalization and cytotoxic action of cholera toxin in rat liver parenchyma....

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  • To assessPseudomonasexotoxin A (ETA) compartmentalization, process-ing and cytotoxicity in vivo, we have studied the fate of internalized ETA with the use of thein vivo rodent liver model following toxin administra-tion, cell-free hepatic endosomes, and pure in vitro protease assays. ETA taken up into rat liver in vivo was rapidly associated with plasma mem-branes (5–30 min), internalized within endosomes (15–60 min), and later translocated into the cytosolic compartment (30–90 min).

    pdf15p viettel02 19-02-2013 7 1   Download

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