Despite my many years of research and teaching in platelet physiology and
pharmacology at the University of Minnesota, I am often confronted with conflicting
opinions as to the relevance of nonnucleated platelets in human health and disease. It
is fascinating to think that how cells with no apparent nucleus, have such a towering
impact on concepts, dealing with often overlapping physiological (i.e. hemostasis,
wound healing, etc.) and pathophysiological (i.e. thrombosis, stroke, atherosclerosis,
wound healing, diabetes, inflammation and cancer) components.