Karnofsky was among the first to champion the evaluation of a chemotherapeutic agent's benefit by carefully quantitating its effect on tumor size and using these measurements to objectively decide the basis for further treatment of a particular patient or further clinical evaluation of a drug's potential.
The taxanes include paclitaxel and docetaxel. These agents differ from the vinca alkaloids in that the taxanes stabilize microtubules against depolymerization. The "stabilized" microtubules function abnormally and are not able to undergo the normal dynamic changes of microtubule structure and function necessary for cell cycle completion. Taxanes are among the most broadly active antineoplastic agents for use in solid tumors, with evidence of activity in ovarian cancer, breast cancer, Kaposi's sarcoma, and lung tumors.
Primary prophylaxis (i.e., shortly after completing chemotherapy to reduce the nadir) of G-CSF to patients receiving cytotoxic regimens is associated with a 20% incidence of febrile neutropenia. "Dose-dense" regimens, where cycling of chemotherapy is intended to be completed without delay of administered doses, may also benefit, but such patients should be on a clinical trial. Administration of G-CSF in these circumstances has reduced the incidence of febrile neutropenia in several studies by about 50%.
Psychiatry is an ever-changing field. The publishers and authors of Complementary and Alternative Medicine Treatments in Psychiatry have made every effort to provide information that is accurate and complete as of the date of publication. However, in view of the rapid changes occurring in mental health treatment, as well as the possibility of human error, this site may contain technical inaccuracies, typographical or other errors. It is the responsibility of the
We have attempted to write a concise modern treatment of differential equations
emphasizing applications and containing all the core parts of a course in differential
equations.Asemester or quarter course in differential equations is taught to most engineering
students (and many science students) at all universities, usually in the second
year. Some universities have an earlier brief introduction to differential equations and
others do not. Some students will have already seen some differential equations in
their science classes.We do not assume any prior exposure to differential equations.
Hepatitis C treatment management is an ever-changing field. The publishers and authors of “The Flying Publisher Guide to Hepatitis C treatment “ have made every effort to provide information that is accurate and complete as of the date of publication. However, in view of the rapid changes occurring in Hepatitis C management, as well as the possibility of human error, this site may contain technical inaccuracies, typographical or other errors. It is the responsibility of the physician who relies on experience and...
The General Agreement on Tariffs and Trade came into force on 1
January 1948. This booklet contains the complete text of the General
Agreement together with all amendments which have become effective
since its entry into force. The text is identical to that published, since 1969,
as Volume IV in the series Basic Instruments and Selected Documents. A
guide to the legal sources of the provisions of the Agreement is provided
in an appendix.
Using a lively, easy-to-read style, The RF and Microwave Circuit Design Cookbook reveals practical, tested methods for designing and implementing a wide range of nonlinear RF and microwave circuits, including all types of mixers, frequency multipliers, and more. A special feature is a complete treatment of FET resistive mixers, which offer the lowest intermodulation distortion of all types of mixers. This book also provides readers with hard-to-find information on creating both square law and envelope diode detectors....
The treatment of contaminated land to eliminate or reduce the presence of
pollutants in the contaminated site has received (and will continue to receive)
considerable attention from the practicing profession. Extensive research and development
are still underway in respect to the delivery of more effective (and economic)
means for site decontamination.
This book aims to give a complete and self-contained presentation of semi-
Markov models with finitely many states, in view of solving real life problems of
risk management in three main fields: Finance, Insurance and Reliability
providing a useful complement to our first book (Janssen and Manca (2006))
which gives a theoretical presentation of semi-Markov theory. However, to help
assure the book is self-contained, the first three chapters provide a summary of
the basic tools on semi-Markov theory that the reader will need to understand our
Endourology is one of the most important subspecialties in the field of urology because
of the widespread use of endoscopy for the diagnosis and treatment of a variety of upper
genitourinary tract pathologies. Although most clinical urologists incorporate some basic
endourology into their practices, complex upper tract pathology and anatomy require
more advanced endoscopic skills and instrumentation.
Advanced Endourology: The Complete Clinical Guide is intended as a resource guide
for all aspects of clinical endourology, particularly the more advanced procedures.
In recent years the study of numerical methods for solving ordinary differential equations has seen many new developments. This second edition of the author's pioneering text is fully revised and updated to acknowledge many of these developments. It includes a complete treatment of linear multistep methods whilst maintaining its unique and comprehensive emphasis on Runge-Kutta methods and general linear methods.
Although the specialist topics are taken to an advanced level, the entry point to the volume as a whole is not especially demanding.
Electromagnetic optics (Chap. 5) provides the most complete treatment of light within the confines of classical optics. It encompasses wave optics, which in turn encompasses ray optics (Fig. 11.0-l). Although classical
This new Third Edition of Mental Health Services: A Public Health Perspective is
being completed in the midst of public debate over President Obama’s health
care reform proposals. Debate over health care is hardly new. The First Edition of
this text was published in 1996, shortly after the rejection of President Clinton’s
health care reform proposal. The Second Edition of this text was published in 2004,
shortly after President Bush’s New Freedom Commission on Mental Health had
issued its fi nal report decrying the state of public mental health in the United
Sensitive skin is becoming a common clinical condition that dermatologists should
be prepared to recognize, understand, and treat.
Subjects experiencing this condition report exaggerated reactions when
their skin is in contact with cosmetics, soaps, and other substances, and they
often report worsening after exposure to dry and cold climates. Sensitive skin
and subjective irritation are widespread in western countries, but still far from
being completely defined and understood.
At a recent meeting of the American Academy of Esthetic
Dentistry a survey questioned whether aesthetic treatment
methods were ethical. The situation typical for that time
was used as basis for the survey: "Let's assume that the
patient is completely healthy and there are no biological or
physical reasons for a therapeutic intervention.
Great advances have been performed in the understanding, diagnosis and treatment of these
diseases but the search of specific protective or risk biomarkers is an unsolved field.
Since completion of the human genome project a rapid progress in genetics and
bioinformatics have enabled the development of multiple tools as well as a large public
databases, which include genetic and genomic data linked to clinical health data.
exciting and stimulating experience. But it can also be
intimidating as you begin your academic journey by
enrolling in an undergraduate, or ‘first’, degree.
An undergraduate degree from Massey’s College of
Business takes three years to complete – if you study full
time from February through November each year, passing
every course you enrol in.
Admission requirements for undergraduate degrees can be
found at: http://enrol.massey.ac.nz
IS MASSEY THE ONE?
Given these considerations, solving the routing problem can be seen as a
choice among three alternatives. Common to the three alternatives is the need
to broadcast some piece of information to all the servers in the network, where
the broadcast is required by the lack of a priori knowledge of locality. The ﬁrst
alternative broadcasts notiﬁcations, which implies that notiﬁcation matching
is performed at each local server based on the subscriptions received at that