Constant stimulation

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  • Although every effort has been made to ensure this guide is free from errors, this publication is sold with the understanding that the authors, editors, and publisher are not responsible for the results of any action taken on the basis of information in this work, nor for any errors or omissions.

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  • Many people have contributed in a variety of ways in the preparation of this book. At Cambridge University Press I would like to thank Alison Sharpe, Barbara Thomas and Geraldine Mark, all of whom have brought their professionalism and expertise to guiding and shaping the book in its various stages. My special thanks are due to Jeanne McCarten, not only for comments on early drafts, but for her constant support and encouragement. Thanks also to Peter Ducker for the design, and to Peter Elliot and Amanda MacPhail for the illustrations.

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  • The mathematical modeling of microstructures in solids is a fascinating topic that combines ideas from different fields such as analysis, numerical simulation, and materials science. Beginning in the 80s, variational methods have been playing a prominent rˆole in modern theories for microstructures, and surprising developments in the calculus of variations were stimulated by questions arising in this context.

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  • The ideas of Johann (John) von Neumann (1903-1957) had a major influence on the architecture of digital computers. He investigated the use of logic gates based on nonlinear dielectric constants. In 1953 he proposed that stimulated emission in a semiconductor material could be used to provide light

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  • Kumagai et al. AMB Express 2011, 1:23 ORIGINAL Open Access Sensitivity to electrical stimulation of human immunodeficiency virus type 1 and MAGIC-5 cells Etsuko Kumagai1*, Masato Tominaga2 and Shinji Harada3 Abstract To determine the sensitivities to low electrical potential of human immunodeficiency virus type 1 (HIV-1) and its target cells, HIV-1 and MAGIC-5 cells were directly stimulated with a constant direct current potential of 1.0 V (vs. Ag/AgCl).

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  • In the search for new ligands for the plasminogen kringle 4 binding-protein tetranectin, it has been found by ligand blot analysis andELISAthat tetranectinspecificallybound to the plasminogen-like hepatocyte growth factor and tissue-type plasminogen activator.The dissociation constants of these complexes were found to be within the same order of mag-nitude as the one for the plasminogen-tetranectin complex. The study also revealed that tetranectin did not interact with the kindred proteins: macrophage-stimulating protein, urokinase-type plasminogen activator and prothrombin....

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  • The signal transducer and activator of transcription (STAT) proteins have initiallybeendescribedas cytoplasmicproteins that enter the nucleus only after cytokine treatment of cells. Contrary to this assumption, it was demonstrated that STATs are constantly shuttling between nucleus and cyto-plasm irrespective of cytokine stimulation. This happens both via carrier-dependent as well as carrier-independent transportation. Moreover, it was also recognized that cyto-kine stimulation triggers nuclear retention of dimeric STATs, rather than affecting the rate of nuclear import. ...

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