Contamination impurities

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  • A key component of the quality of pharmaceutical drugs is the control of impurities. It is important to identify and quantify levels of impurities that may be present to provide safe, effective and well-controlled medicines. The measurement and identification of impurities to today’s standards presents significant challenges to the analytical chemist.

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  • Introduction: Small amount of drugs and poisons incorporated into human bodies are hidden among large amounts of biological components, such as proteins, lipids, nucleic acids and membranes. It is not easy to detect only a target compound from such complicated matrices. Before instrumental analysis, extraction procedure is usually essential and very important.

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  • In the past several years, there have been many developments in the materials for lead–acid batteries. Silver in grid alloys for high temperature climates in SLI batteries has increased the silver content of the recycled lead stream. Concern about silver and other contaminants in lead for the active material for VRLA batteries led to the initiation of a study by ALABC at CSIRO. The study evaluated the effects of many different impurities on the hydrogen and oxygen evolution currents in float service for flooded and VRLA batteries at different temperatures and potentials. ...

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  • For more than 30 years there has been remarkable growth in the need for quality water purification by all categories of users – municipal, industrial, institutional, medical, commercial and residential. The increasingly broad range of requirements for water quality has motivated the water treatment industry to refine existing techniques, combine methods and explore new water purification technologies.

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  • Beneficiation (or concentration) processes are gener- ally used to upgrade the phosphate content by removing contaminants and barren material prior to further processing. A few ores are of sufficiently high quality to require no further concentration. The natu- rally occurring impurities contained in phosphate rock ore depend heavily on the type of deposit (sedi- mentary or igneous), associated minerals, and the extent of weathering. Major impurities can include organic matter, clay and other fines, siliceous material, carbonates, and iron bearing minerals.

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  • Worldwide per capita consumption of alcoholic beverages in 2005 equaled 6.13 litres of pure alcohol consumed by every person aged 15 years or older. A large portion of this consumption – 28.6% or 1.76 litres per person – was homemade and illegally produced alcohol or, in other words, unrecorded alcohol. The consumption of homemade or illegally produced alcohol may be associated with an increased risk of harm because of unknown and potentially dangerous impurities or contaminants in these beverages. A large variation exists in adult per capita consumption (Figure 1).

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  • Impurities in the purge gas, organic compounds outgassing from the plumbing ahead of the trap, and solvent vapors in the laboratory account for the majority of contamination problems. The analytical system must be demonstrated to be free from contamination under the conditions of the analysis by running laboratory reagent blanks as described in Section 8.1.3. The use of non-Teflon plastic tubing, non-Teflon thread sealants, or flow controllers with rubber components in the purge and trap system should be avoided....

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