Melatonin is synthesized by an enzymatic pathway, in
which arylalkylamine (serotonin)N-acetyltransferase cata-lyzes the rate-limiting step. Aprevious study [Khalil, E.M.,
DeAngelis, J., Ishii,M.&Cole, P.A. (1999)Proc.NatlAcad.
Sci. USA 96, 12418–12423] reported the discovery of
bromoacetyltryptamine (BAT), a new type of inhibitor of
this enzyme. This compound is the precursor of a potent
bifunctional inhibitor (analogue of the transition state),
capable of interfering with both the substrate and the
cosubstrate binding sites. ...