Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: bcl-2 expression is not associated with survival in metastatic cutaneous melanoma: A historical cohort study
(BQ) Part 2 book "Radiation treatment and radiation reactions in dermatology" presents the following contents: Superficial radiation therapy in an office setting, tumor staging in dermatology, treatment of precancerous lesions, electron therapy of skin carcinoma, cutaneous melanoma, side effects of radiation treatment,...
Ocular melanoma (ung thư tế bào sắc tố đen của mắt) rất hiếm, trong hơn 25 năm qua (xem consulatations cho medical oncology), tôi chỉ thấy có 4 cases. Dĩ nhiên các ophthalmologists phải thấy thường hơn. Melanoma thường thấy hơn là melanoma ở ngoài da (cutaneous melanoma) hay màng nhầy.
Harrison's Internal Medicine Chapter 83. Cancer of the Skin
Melanoma Pigmented lesions are among the most common findings on skin examination. The challenge is to distinguish cutaneous melanomas, which may be lethal, from the remainder, which with rare exceptions are benign. Examples of malignant and benign pigmented lesions are shown in Fig. 83-1.
Atypical and malignant pigmented lesions. The most common melanoma is superficial spreading melanoma (not pictured). A.
There are four types of cutaneous melanoma (Table 83-2). In three of these—superficial spreading melanoma, lentigo maligna melanoma, and acral lentiginous melanoma—the lesion has a period of superficial (so-called radial) growth during which it increases in size but does not penetrate deeply. It is during this period that the melanoma is most capable of being cured by surgical excision. The fourth type—nodular melanoma—does not have a recognizable radial growth phase and usually presents as a deeply invasive lesion, capable of early metastasis.
There has been a case report of exaggerated
pigmented granulomatous reaction to the artificial joint implant in a 72-year-old man who
had undergone bilateral total hip arthroplasty, in whom, aspirate from the inguinal region
was misinterpreted as metastatic melanoma from an unknown primary. Microscopically, the
smears of this patient showed both intracellular and extracellular black pigment with
obscured cytomorphology; although, appreciable cells were reported to be pleomorphic
with prominent nucleoli. The patient had no evidence of primary cutaneous melanoma.
Ten years ago, as we put together the first edition of
Men’s Health, we asked an important question:
‘Why do men die on average five years younger than
women?’ A decade later, although we now have at
least a partial answer, namely that men look after
themselves less well than women, the so-called gender
gap still persists. The key issue then for
readers of the third edition of this book is what
can be done to narrow this gap, thereby allowing
men to live longer and healthier lives. This is
precisely the problem that we have asked each
of our authors to address.
Melanoma Pigmented lesions are among the most common findings on skin examination. The challenge is to distinguish cutaneous melanomas, which may be lethal, from the remainder, which with rare exceptions are benign. Examples of malignant and benign pigmented lesions are shown in Fig. 83-1. Figure 83-1
Atypical and malignant pigmented lesions. The most common melanoma is superficial spreading melanoma (not pictured).
Cancer of the skin (including melanoma and basal and squamous cell skin cancers) is by far
the most common of all types of cancer. An estimated 3.5 million basal and squamous cell
skin cancers are diagnosed each year (occurring in about 2.2 million Americans, as some
people have more than one). Most of these are basal cell cancers. Squamous cell cancers
occur less often.
The number of these cancers has been increasing for many years. This is probably due to a
combination of better skin cancer detection, people getting more sun exposure, and people
(BQ) Part 1 book "Personalized treatment options in dermatology" presents the following contents: Concept and scientific background of personalized medicine; melanoma - from tumor specific mutations to a new molecular taxonomy and innovative therapeutics; targeted and personalized therapy for nonmelanoma skin cancers; personalized treatment in cutaneous T-cell lymphoma.
The entire cutaneous surface, including the scalp and mucous membranes, should be examined in each patient. Bright room illumination is important, and a 7x to 10x hand lens is helpful for evaluating variation in pigment pattern. A history of relevant risk factors should be elicited. Any suspicious lesions should be biopsied, evaluated by a specialist, or recorded by chart and/or photography for follow-up. Examination of the lymph nodes and palpation of the abdominal viscera are part of the staging examination for suspected melanoma.
Any pigmented cutaneous lesion that has changed in size or shape or has other features suggestive of malignant melanoma is a candidate for biopsy. The recommended technique is an excisional biopsy, as that facilitates pathologic assessment of the lesion, permits accurate measurement of thickness if the lesion is melanoma, and constitutes treatment if the lesion is benign.