The first concern with contingency planning is to identify times when the event may place
strains on the existing public safety agencies. Even in the earliest stages of planning, you
should begin also to make contingency plans. These plans should consider licensing and
regulations, emergency response issues, identifying persons responsible for particular types
of hazards and risks, resources and expenses, and jurisdictions. Planning ahead reduces
stress for organizers and promoters during the event, if an incident occurs that requires
public agencies to work together.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus...
Abstract Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells and epidermal keratinocytes. Dysregulated cytokine production, orchestrated by activated T-cells homing to the skin, is believed to be the main cause of psoriasis, a common inflammatory skin disorder.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines
Cytokine receptors are crucial for the maintenance, regulation and growth
of cells in multicellular organisms. As a common theme in cytokine signal-ling, single-span receptor chains are assembled in the cell membrane by a
ligand enabling cross-activation of the aligned cytoplasmic receptor
Plasminogen activator inhibitor type 2 (PAI-2; SERPINB2)is a highly-regulated gene that is subject to both transcriptional and post-transcrip-tional control. For the latter case, inherent PAI-2 mRNA instability was
previously shown to require a nonameric adenylate-uridylate element in the
Tristetraprolin is a zinc-finger-containing RNA-binding protein. Tristetra-prolin binds to AU-rich elements of target mRNAs such as proto-onco-genes, cytokines and growth factors, and then induces mRNA rapid
degradation. It was observed as an immediate-early gene that was induced
in response to several kinds of stimulus, such as insulin and other growth
factors and stimulators of innate immunity such as lipopolysaccharides.
The macrophage is critical to the innate immune response and contributes
to human diseases, including inflammatory arthritis and plaque formation
in atherosclerosis. Vascular endothelial growth factor (VEGF) is an angio-genic cytokine that is produced by macrophages.
Stress-activated protein kinase (SAPK) signaling plays essential roles in eliciting adequate cellular responses to stresses and proinﬂammatory cytokines. SAPK pathways are composed of three successive protein kinase reactions. The phosphorylation of SAPK signaling components on Ser/Thr or Thr/Tyr residues suggests the involvement of various protein phosphatases in the negative regulation of these systems.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Negative regulation of cytokine signaling and immune responses by SOCS proteins...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway...
Cancer, although a dreadful disease, is at the same time a fascinating biological
phenotype. Around 1980, cancer was first attributed to malfunctioning genes and,
subsequently, cancer research has become a major area of scientific research supporting
the foundations of modern biology to a great extent. To unravel the human
genome sequence was one of those extraordinary tasks, which has largely
been fuelled by cancer research, and many of the fascinating insights into the
genetic circuits that regulate developmental processes have also emerged from
research on cancer....
Parasitic nematodes can downregulate the immune response of their hosts
through the induction of immunoregulatory cytokines such as interleukin-10 (IL-10). To define the underlying mechanisms, we measuredin vitro the
production of IL-10 in macrophages in response to cystatin fromAcantho-cheilonema viteae, an immunomodulatory protein of filarial nematodes, and
developed mathematical models of IL-10 regulation.
Interaction of cytokines with their cognate receptors leads
to the activation of latent transcription factors, the signal
transducer and activator of transcription (STAT) proteins.
Numerous studies have identified the critical roles played
by STAT proteins in regulating cell proliferation, differ-entiation and survival. Consequently, the activity of STAT
proteins is negatively regulated by a variety of different
mechanisms, which include alternative splicing, covalent
modifications, protein–protein interactions with negative
regulatory proteins and proteolytic processing by pro-teases....
Inducible nitric oxide synthase (iNOS) functions as a homodimer. In cell
extracts, iNOS molecules partition both in cytosolic and particulate frac-tions, indicating that iNOS exists as soluble and membrane associated
forms. In this study, iNOS features were investigated in human intestinal
epithelial cells stimulated with cytokines and in duodenum from mice
exposed to flagellin. Our experiments indicate that iNOS is mainly associ-ated with the particulate fraction of cell extracts.
In this study, we show that the G protein-coupled receptor
agonist thrombin, the glycoprotein VI agonist convulxin,
and the cytokine receptor Mpl agonist thrombopoietin
(TPO) are able to induce activation of RAS in human
platelets. Recruitment ofGRB2 by tyrosine-phosphorylated
proteins in response to TPO and convulxin but not by
thrombin occurred with a similar time-course to RAS acti-vation, consistent with a causal relationship.
The ultimate goal of cancer research is the development of effective anticancer
therapy. During the last several decades, the discovery of oncogenes, tumor
suppressors, growth factors, signal transduction pathways has dramatically
escalated our understanding of cancer cell biology and mechanisms of cell
transformation.1-3 Hundreds of cellular proteins and pathways have been logically
considered as molecular targets in a mechanism-based approaches of anticancer drug
Yet, the progress in cancer treatment has not paralleled these dramatic achievements
in basic research.
Retroviral vectors have gained an increasing value in gene therapy because they stably deliver
therapeutic genes to the host cell genome. These therapeutic genes are supposed to rectify
consequences of inherited and acquired mutated genes in the host cell genome, or alter host
cell function to cure diseases.