Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Quantitative analysis of interferon alpha receptor subunit 1 and suppressor of cytokine signaling 1 gene transcription in blood cells of patients with chronic hepatitis C
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15)
Death-associated protein kinase-1 (DAPK) is the
prototypic member of a family of death-related kinases
that was originally identified as a factor that regulates
apoptosis in response to the death-inducing cytokine
Cytokine receptors are crucial for the maintenance, regulation and growth
of cells in multicellular organisms. As a common theme in cytokine signal-ling, single-span receptor chains are assembled in the cell membrane by a
ligand enabling cross-activation of the aligned cytoplasmic receptor
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Negative regulation of cytokine signaling and immune responses by SOCS proteins...
Abstract Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells and epidermal keratinocytes. Dysregulated cytokine production, orchestrated by activated T-cells homing to the skin, is believed to be the main cause of psoriasis, a common inflammatory skin disorder.
Erythropoietin (Epo) is a hematopoietic cytokine that is
crucial for the differentiation and proliferation of erythroid
progenitor cells. Epo acts on its target cells by inducing
homodimerization of the erythropoietin receptor (EpoR),
thereby triggering intracellular signaling cascades. The
EpoR encompasses eight tyrosine motifs on its cytoplasmic
tail that have been shown to recruit a number of regulatory
Several hematopoietic growth factors (HGFs) have achieved widespread clinical
application. In the United States alone, more than US $5 billion per year of the health care
budget is spent on these factors. The first patients were treated with recombinant human
erythropoietin (rHuEPO, epoetin alfa, Epogen®) in 1985 and the first patients received
recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF,
filgrastim, Neupogen®) or recombinant human granulocyte-macrophage colonystimulating
factor (rHuGM-CSF, sargramostim, Leukine® or Prokine®) in 1986.
The suppressors of cytokine signalling (SOCS) proteins inhibit
cytokine signalling by direct interaction with Janus kinases
(JAKs) or activated cytokine receptors. In addition to the N-ter-minal and SH2 domains that mediate these interactions, SOCS
proteins contain a C-terminal SOCS box. Evidence suggests
SOCS box-containing proteins act as part of an elongin-cullin-SOCS (ECS) E3 ubiquitin ligase complex, marking target pro-teins for degradation.
SOCS3 is a negative regulator of cytokine signalling that inhibits Janus
kinase-signal transduction and activator of transcription (JAK-STAT)
mediated signal tranduction by binding to phosphorylated tyrosine residues
on intracellular subunits of various cytokine receptors, as well as possibly
the JAK proteins.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus...
Interleukin (IL)-6-type cytokines exert their effects through activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade. The JAK/STAT pathways play an important role in rheumatoid arthritis, since JAK inhibitors have exhibited dramatic effects on rheumatoid arthritis (RA) in clinical trials. In this study, we investigated the molecular effects of a small molecule JAK inhibitor, CP690,550 on the JAK/STAT signaling pathways and examined the role of JAK kinases in rheumatoid synovitis....
Staphylococcus aureusand Streptococcus pyogenes(group A streptococci)
are Gram-positive pathogens capable of producing a variety of bacterial exo-toxins known as superantigens. Superantigens interact with antigen-present-ing cells (APCs) and T cells to induce T cell proliferation and massive
cytokine production, which leads to fever, rash, capillary leak and subse-quent hypotension, the major symptoms of toxic shock syndrome.
Developing thymocytes and T cells express the Tec kinases Itk, Rlk⁄Txk
and Tec, which are critical modulators of T-cell receptor signaling, required
for full activation of phospholipase Cc, and downstream Ca
and ERK-mediated signaling pathways.
The regulation of cytokines and pro-inflammatory genes is an absolute
essentiality to combat inflammatory diseases. The present study investigated
the effects of 4-O-chloroacetyl-2,3-di-O-acetyl-6-O-levulinoyl-b-d-glucopyr-anosyl]-(1-3)-1-O-(p-methoxyphenyl)-2-deoxy-2-N-trichloroacetyl-4,6-O-ben-zylidene-a-d-glucopyranoside (RSCL-0409), a novel small molecule Toll-like
receptor (TLR) signalling antagonist, and its mechanism of action in human
monocytic (THP-1) cells stimulated with lipopolysaccharide (LPS)....
The signal transducers and activators of transcription (STATs) convey sig-nals from the membrane to the nucleus in response to cytokines or growth
factors. STAT3 is activated in response to cytokines involved mostly in cell
proliferation; STAT1 is activated by cytokines, including interferon-c,
involved in defence against pathogens and the inhibition of cell prolifera-tion.
Prokineticins are a novel family of secreted peptides with diverse regulatory
roles, one of which is their capacity to modulate immunity in humans and
in other species. Prokineticins are small peptides of 8 kDa that mediate
their biological activities by signaling through two homologous G-protein-coupled receptors (prokineticin receptor 1 and prokineticin receptor 2).
The leptin receptor (LEPR) is a class I cytokine receptor signalling via
both the janus kinase⁄signal transducer and activator of transcription
(JAK⁄STAT) and the MAP kinase pathways. In addition, leptin has been
shown previously to activate AMP-activated kinase (AMPK) in skeletal
muscle. To enable a detailed analysis of leptin signalling in pancreatic beta
cells, LEPR point mutants with single or combined exchanges of the three
intracellular tyrosines were expressed in HIT-T15 insulinoma cells....