TB spreads through the air from one person to another. The bacteria are put into the air
when a person with active TB disease of the lungs or throat coughs or sneezes. People
nearby may breathe in these bacteria and get infected. When a person breathes in TB
bacteria, which may settle in the lungs and begin to grow. From there, they can move
through the blood to other parts of the body, such as the kidney, spine, and brain. TB in the
lungs or throat can be infectious. This means that the bacteria can spread to other people. TB...
Previous results have shown that theoncoembryonicmarker
a-fetoprotein (AFP) is able to induce apoptosis in tumor
cells through activation of caspase 3, bypassing Fas-dependent and tumor necrosis factor receptor-dependent
signaling. In this study we further investigate the molecular
interactions involvedin the AFP-mediatedsignaling of
apoptosis. We show that AFP treatment of tumor cells is
accompaniedby cytosolic translocation of mitochondrial
To establish an infection, Yersinia pseudotuberculosis utilizes a plasmid-encoded type III secretion machine that permits the translocation of several anti-host factors into the cytosol of target eukaryotic cells. Secreted YopD is essential for this process. Pre-secretory stabilization of YopD is mediated by an interaction with its cognate chaperone, LcrH. YopD possesses LcrH binding domains located in the N-terminus and in a predicted amphipathic domain located near the C-terminus. This latter domain is also critical for Yersinia virulence. ...