Xeroderma pigmentosum (XP) is an inherited disease in which cells from
patients exhibit defects in nucleotide excision repair (NER). XP proteins
A–G are crucial in the processes of DNA damage recognition and incision,
and patients with XP can carry mutations in any of the genes that specify
Ionizing radiation, oxidative stress and endogenous DNA-damage pro-cessing can result in a variety of single-strand breaks with modified 5¢
and⁄or 3¢ ends. These are thought to be one of the most persistent
forms of DNA damage and may threaten cell survival. This study
addresses the mechanism involved in recognition and processing of
DNA strand breaks containing modified 3¢ ends.
In recent years, the business implications of climate change have gained considerable
recognition among companies and investors. However, much of this attention has focused
on energy policy and greenhouse gas (GHG) emissions, while neglecting the implications of
changing precipitation patterns and resulting water scarcity and water quality risks.
Much has changed in the 30 years I have practiced
medicine, though perhaps no change
has been as significant as our collective attitude
toward health. The technological knowledge and
innovations that marked the latter decades of the
20th century have made it possible for us to repair
damaged hearts, cure many forms of cancer, and
even replace diseased organs. Men today can expect
to live a third as long as did their grandfathers.
The second part of the book is dedicated to the pathogenesis of myocarditis. The
chapters in this part also discuss some clinical findings, but mostly focus on the
underlying mechanism of the disease, using in-depth data from mouse models. Some
of the chapters focus on host immune response. For example, one chapter reviews the
role of pattern-recognition receptors in myocarditis, and another chapter examines the
role of lymphocyte effectors in myocarditis pathogenesis.