Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Recent studies indicate that histone deacetylase is a direct target of valproic acid. Methods: In the present study, we have used histological analysis and RT-PCR assays to examine the cardiac abnormalities in mice treated with sodium valproate (NaVP) and determined the effects of NaVP on histone deacetylase activity and the expression...
Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. In eukaryotes, sirtuins regulate transcriptional repression, recombination, the celldivision cycle, microtubule organization, and cellular responses to DNA-damaging agents. Sirtuins have also been implicated in regulating the molecular mechanisms of aging. The Sir2 catalytic domain,
The book "Biotechnology of Biopolymers" comprises 17 chapters covering occurrence, synthesis, isolation and production, properties and applications, biodegradation and modification, the relevant analysis methods to reveal the structures and properties of biopolymers and a special section on the theoretical, experimental and mathematical models of biopolymers.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence...
Saccharomyces cerevisiaecells control their cell size at a point in late G1
called Start. Here, we describe a negative role for the Sin3⁄Rpd3 histone
deacetylase complex in the regulation of cell size at Start. Initiation of
⁄S-specific transcription ofCLN1, CLN2andPCL1in a sin3Dstrain
occurs at a reduced cell size compared with a wild-type strain.
Endogenous mono-ADP-ribosylation in eukaryotes is involved in regulating
protein synthesis, signal transduction, cytoskeletal integrity, and cell prolifer-ation, although few cellular ADP-ribosyltransferases have been identified.
The sirtuins constitute a highly conserved family of protein deacetylases, and
several family members have also been reported to perform protein ADP-ribosylation.