We previously identified a novel interaction between tuberous sclerosis-2
(TSC2) and death-associated protein kinase-1 (DAPK), the consequence
being that DAPK catalyses the inactivating phosphorylation of TSC2 to
stimulate mammalian target of rapamycin complex 1 (mTORC1) activity.
I got the opportunity to associate myself with Dr. Raj Pal Singh, senior scientist, Polymer
Chemistry Division, National Chemical Laboratory Pune, as my supervisor. As an
outstanding scientist and teacher he has given me the benefit of his guidance throughout
the course work. I am grateful to him for showing me all the angles of research life.
The term ‘architectural tile scheme’ covers a very broad church of
ceramic decoration found usually on the inside but also frequently on
the outside of buildings. Tiles are superficial to the structure of the
building, being used to cover walls, floors and sometimes ceilings for
both functional and decorative reasons.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Rho iso-alpha acids from hops inhibit the GSK-3/NF-κB pathway and reduce inflammatory markers associated with bone and cartilage degradation...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: "GPG-NH2 acts via the metabolite aHGA to target HIV-1 Env to the ER-associated protein degradation pathway...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Timing is everything: early degradation of abscission layer is associated with increased seed shattering in U.S. weedy rice
Recently, a novel uracil-DNA-degrading factor protein (UDE) was identi-fied inDrosophila melanogaster, with homologues only in pupating insects.
Its unique uracil-DNA-degrading activity and a potential domain organiza-tion pattern have been described.
Autophagy is an evolutionarily conserved lysosomal pathway used to
degrade and recycle long-lived proteins and cytoplasmic organelles. This
homeostatic ability makes autophagy an important pro-survival mechanism
in response to several stresses, such as nutrient starvation, hypoxia, dam-aged mitochondria, protein aggregation and pathogens.
We have shown previously that isolated heat shock protein 90 (HSP90)
and nitric oxide synthase (NOS), once associated in a heterocomplex,
become completely resistant to calpain digestion. In this study, it is shown
that, in vivo, under conditions of calpain activation, the protection of NOS
Autophagy is a nonspecific bulk degradation pathway for long-lived cyto-plasmic proteins, protein complexes, or damaged organelles. This process is
also a major degradation pathway for many aggregate-prone, disease-cau-sing proteins associated with neurodegenerative disorders, such as mutant
huntingtin in Huntington’s disease. I
Endoplasmic reticulum-associated degradation of newly
synthesized glycoproteins has been demonstrated previously
using various mammalian cell lines. Depending on the cell
type, glycoproteins bearingMan9 glycans and glycoproteins
bearing Man5 glycans can be efficiently degraded. Awide
variety of variables can lead to defective synthesis of lipid-linked oligosaccharides and, therefore, in mammalian cells,
species derived fromMan9GlcNAc2 orMan5GlcNAc2 are
often recovered on newly synthesized glycoproteins. ...
The C-terminal t peptide (40 residues) of vertebrate acetyl-cholinesterase (AChE) T subunits possesses a series of seven
conserved aromatic residues and forms an amphiphilic
a-helix; it allows the formation of homo-oligomers (mono-mers, dimers and tetramers) and heteromeric associations
with the anchoringproteins, ColQ and PRiMA, which
contain a proline-rich motif (PRAD). We analyzed the
influenceofmutations in the t peptideofTorpedoAChETon
oligomerization and secretion.
Purified, nonubiquitinated growth-associated protein of
43 kDa (GAP-43) was attacked by purified reticulocyte 20S
12 N-terminally labelled GAP-43 fragments that could be
resolved by SDS/PAGE. Inhibitor experiments suggested
that proteasomeb1 activity yielded the resolved bands and
that proteasome b5 activity generated nonresolvable frag-ments. Processive degradation, yielding only nonresolvable
fragments, therefore did not occur.
Matrix metalloproteinase (MMP)-3 inhibited human
MDA-MB-231 breast cancer cell invasion through recon-stituted basement membranein vitro. Inhibition of invasion
was dependent upon plasminogen and MMP-3 activation,
was impaired by the peptide MMP-3 inhibitor Ac-Arg-Cys-Gly-Val-Pro-Asp-NH2 and was associated with: rapid
MMP-3-mediated plasminogen degradation to microplas-minogen and angiostatin-like fragments;
The presenilin complex, consisting of presenilin, nicastrin, anterior pharynx
defective-1 and presenilin enhancer-2, constitutes c-secretase, which is
required for the generation of amyloid b-protein. In this article, we show
that Synoviolin (also called Hrd1), which is an E3 ubiquitin ligase implicated
in endoplasmic reticulum-associated degradation
The ubiquitination and subsequent degradation of stress-induced abnormal
proteins are indispensable to cell survival. We previously showed that a
yeast (Saccharomyces cerevisiae) mutant carrying a single amino acid
change, Ala401Glu, in RSP5, which encodes an essential E3 ubiquitin
ligase, is hypersensitive to various stresses.
The metalloendopeptidase 24.15 (EP24.15) is ubiquitously present in the
extracellular environment as a secreted protein. Outside the cell, this
enzyme degrades several neuropeptides containing from 5 to 17 amino
acids (e.g. gonadotropin releasing hormone, bradykinin, opioids and neuro-tensin). The constitutive secretion of EP24.15 from glioma C6 cells was
demonstrated to be stimulated linearly by reduced concentrations of extra-cellular calcium.
Forensic engineering is the application of engineering principles and methodologies
to answer questions of fact. These questions of fact are usually associated with accidents, crimes, catastrophic events, degradation of property,
and various types of failures.
process both reduces collagen synthesis by
inhibiting the smooth muscle cell and causes its
death by apoptosis. Macrophages also produce
a wide range of metalloproteinases capable of
degrading all the components of the connective
tissue matrix, including collagen. These metalloproteinases
are secreted into the tissues in an
inactive form and then activated by plasmin.
Metalloproteinase production by macrophages
is upregulated by inflammatory cytokines such
However, risks are inherent in any wireless technology. Some of these risks are similar to those of wired
networks; some are exacerbated by wireless connectivity; some are new. Perhaps the most significant
source of risks in wireless networks is that the technology’s underlying communications medium, the
airwave, is open to intruders, making it the logical equivalent of an Ethernet port in the parking lot.
The loss of confidentiality and integrity and the threat of denial of service (DoS) attacks are risks
typically associated with wireless communications.