Since this book was first published in 1998, there have been significant advances in
our understanding of the morphology of the skin and the properties that govern the
transport of molecules into and across the three major strata. The multitude of data
that has been generated has allowed the development of predictive models for both
the rate and extent of dermal absorption and has increased our ability to predict the
likelihood of local toxic events subsequent to solute penetration and permeation.
Paradoxically, skin is both a primary barrier to systemic absorption of topically
exposed chemicals and a portal to systemic delivery of transdermal medicaments.
Knowledge of the factors that determine both extent and rate of chemical flux across
the skin is an important component of both toxicology and pharmacology studies.
The aim of this book is to provide current approaches and techniques by which
dermal absorption may be quantitated utilizing end points relative to these two
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Dermal absorption of aromatic amines in workers with different skin lesions: a report on 4 cases