Search is among the most disruptive innovations of our time. It influences what we buy and where we go. It shapes how we learn and what we believe. In this provocative and inspiring book, you'll explore design patterns that apply across the categories of web, ecommerce, enterprise, desktop, mobile, social, and real-time search and discovery.
Serum prostate specific antigen (PSA) is the only biomarker routinely used for the early
detection of prostate cancer, but it is not a perfect test. Although PSA is highly specific for
prostate, an elevated level is not specific for cancer, being increased in benign hyperplasia
and prostatitis (Pungalia, 2006; Bozeman, 2002). Consequently, the majority of men with
an increased serum PSA do not have prostate cancer and thus undergo unnecessary
Product designers learned years ago that
they’d save time and money if they consulted
with their colleagues in manufacturing rather
than just throwing new designs over the wall.
The two functions realized it wasn’t enough to
just coexist—not when they could work together
to create value for the company and for
customers. You’d think that marketing and
sales teams, whose work is also deeply interconnected,
would have discovered something
As a prologue to these activities, the Research and Evaluation Division of
BRAC (www.bracresearch.org) has carried out a review of the existing
MNCH programmes in Bangladesh undertaken by the government, NGOs
and private sectors to identify best practices and the factors behind
successes and failures, thereby pinpointing gaps and challenges. This
provides an evidence base to develop informed intervention components,
approaches and strategies for the MNCH initiatives in the country and
endow with directions for future advocacy efforts.
Medicinal chemistry is a discipline at the intersection of chemistry, especially synthetic
organic chemistry, and pharmacology and various other biological specialties, where
they are involved with design, chemical synthesis and development for market of
pharmaceutical agents (drugs). Compounds used in medical applications are most
often organic compounds, which are often divided into the broad classes of small
organic molecules and biologics, the latter of which are most often medicinal
preparations of proteins. Inorganic and organometallic compounds are also useful as
People who pursue careers in Internal Medicine are drawn to
the specialty by a love of patients, mechanisms, discovery,
education, and therapeutics. We love hearing the stories told
to us by our patients, linking signs and symptoms to pathophysiology,
solving the diagnostic dilemmas, and proposing
strategies to prevent and treat illness. It is not surprising
given these tendencies that internists prefer to continue their
life-long learning through problem solving.
This book is offered as a companion to the remarkable
17th edition of Harrison’s Principles of Internal Medicine.
We normally think of the eye as an organ for vision, but due to the discovery of
additional nerve connections from recently-detected novel photoreceptor cells in
the eye to the brain, it is now understood how light also mediates and controls a
large number of biochemical processes in the human body. The most important
findings are related to the control of the biological clock and to the regulation of
some important hormones through regular light-dark rhythms. This in turn means
that lighting has a large influence on health, well-being and alertness.
In recent years, completion of the sequencing of the human genome as well as the
genomes of dozens of other organisms and subsequent development of tools for comprehensive
analysis of other cellular constituents have revolutionized biology. These new
technologies, referred to broadly as “genomics,” have integrated biologic sciences with
information sciences and engineering.
Tuyển tập các báo cáo nghiên cứu khoa học ngành toán học được đăng trên tạp chí toán học quốc tế đề tài: Design and field evaluation of geographical location-aware service discovery on IPv6 GeoNetworking for VANET
Ferroelectricity has been one of the most used and studied phenomena in both scientific
and industrial communities. Properties of ferroelectrics materials make them particularly
suitable for a wide range of applications, ranging from sensors and actuators
to optical or memory devices. Since the discovery of ferroelectricity in Rochelle Salt
(which used to be used since 1665) in 1921 by J. Valasek, numerous applications using
such an effect have been developed.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Design and field evaluation of geographical location-aware service discovery on IPv6 GeoNetworking for VANET
important regulators of biological processes in animals
and plants. MiRNAs regulate gene expression at
the posttranscriptional level by binding to mRNAs and
either inhibit translation or modify the stability of the
mRNA. Due to the important biological role of miRNAs
it is of great interest to study their expression level in
the cells. Furthermore, miRNAs have been associated
with cancer and other diseases  and miRNA expression
can help in the diagnosis and prognostic of human
Discovery of a new chemical entity that exerts pharmacological effects for
curing or treating diseases or relieving symptoms is only the first step in
the drug developmental process. In the developmental cycle of a new
drug, the delivery of a desired amount of a therapeutic agent to the target
at a specific time or duration is as important as its discovery. In order
to realize the optimal therapeutic outcomes, a delivery system should
be designed to achieve the optimal drug concentration at a predetermined
rate and at the desired location....
The discovery of RNA interference (RNAi) generated considerable interest
in developing short interfering RNAs (siRNAs) for understanding basic
biology and as the active agents in a new variety of therapeutics. Early
studies showed that selecting an active siRNA was not as straightforward
as simply picking a sequence on the target mRNA and synthesizing the
siRNA complementary to that sequence.
With publication of the human genome has come an
experiment in reductionism for drug discovery. With the
evaluation of the number and quality of new drug
treatments from this approach has come a reevaluation
of target-based versus systems-based strategies. Pharmacology,
historically rooted in systems-based approaches
and designed to give systems-independent measures
of drug activity, is suitably poised to be a major (if
not the major) tool in this new environment of drug
We present Wikulu1 , a system focusing on supporting wiki users with their everyday tasks by means of an intelligent interface. Wikulu is implemented as an extensible architecture which transparently integrates natural language processing (NLP) techniques with wikis. It is designed to be deployed with any wiki platform, and the current prototype integrates a wide range of NLP algorithms such as keyphrase extraction, link discovery, text segmentation, summarization, or text similarity.
This work is Namibia Training Authority copyright. It may be reproduced in whole or
part for study and training purposes, subject to the inclusion of an acknowledgement
of the source and provided it is not being used for commercial sale or use.
Reproduction for purposes other than those indicated above requires the written
permission of the Project Management Unit of the Namibia Training Authority.
The views expressed in this manual do not necessarily represent the views of the
Ministry of Education, nor those of the Government of the Republic of Namibia.
Unique innovations stem from multiple collaborations: augmented reality is used to treat disease via
simulated internal radiation therapy (Computer Vision and Systems Laboratory/LVSN); geospace
technologies are used in the production of interactive games (GeoEduc3D); dynamic intelligence is
used to create training applications for golfers (Pro Mental Coach, Frima, Brain Centre); artiﬁcial
intelligence (twinned with man/machine interfaces) is found in the development of serious game
training simulations (DRDC Valcartier).
In our view, the most reliable estimate available is a total value of U.S. corporations
of 1.54 times GNP, or 17.5 times after-tax corporate earnings. This estimate is based on a
detailed study of 135 industrial corporations done by Laurence Sloan and Associates (1936)
at the Standard Statistics Company, a company that later merged with Poor’s Publishing
to become Standard and Poor’s (S&P). The estimate we will use, however, is a total value
of 1.67 times GNP (or 19 times after-tax corporate earnings). This estimate is based on the
price-earnings ratio of the S&P composite stock index.
Composites or composite materials are a combination of materials which provide different physical characteristics than either material separately. Composite material research within mechanical engineering typically focuses on designing (and, subsequently, finding applications for) stronger or more rigid materials while attempting to reduce weight, susceptibility to corrosion, and other undesirable factors. Carbon fiber reinforced composites, for instance, have been used in such diverse applications as spacecraft and fishing rods....