Developmental pharmacology

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  • This book is designed to fit into a handbag or shirt pocket. It contains material which is usually required in a hurry when treating a critically ill or injured infant or child. In addition to information relevant to emergency care, there are what we hope will be useful pages of data on subjects which without a photographic memory would normally require reference to a paediatric text book. Examples include a weight for height chart, normal values for common biochemical tests, normal developmental profiles and normal ECG measurements....

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  • Over the past 2 decades the implications of endocrine disruption and modula- tion have permeated public consciousness, scienti fi c inquiry, regulatory frame- works, and management decisions in the environmental and biomedical sciences.

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  • In humans, the normal diploid number of chromosomes is 46, consisting of 22 pairs of autosomal chromosomes (numbered 1–22 in decreasing size) and one pair of sex chromosomes (XX in females and XY in males). The genome is estimated to contain between 30,000 and 40,000 genes. Even the smallest autosome contains between 200 and 300 genes. Not surprisingly, duplications or deletions of chromosomes, or even small chromosome segments, have profound consequences on normal gene expression, leading to severe developmental and physiologic abnormalities. ...

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  • Group psychotherapy is widely practised with different populations, in different settings, using different approaches based on different theories of the mind, with different degrees of success. The accent here is on differences . How is a clinician new to this modality to make sense of this diversity and formulate a personal approach to leading a group? One ’ s group leadership supervision, course work, and conferences, are indispensible for professional development.

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  • Children, in general, are healthier than their adult counterparts, particularly as adults reach the fifth decade of life and beyond. However, children do have multiple acute illnesses each year, and a substantial number of children, often estimated to be 20 percent or more, are burdened with chronic health disorders, some of them disabling or life threatening. Medical attention, including evidence-based prescription of drugs or biologics, is vital for their well-being.

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  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

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