During development, cells and tissues undergo dynamic changes in pattern
and form that employ a wider range of physical mechanisms than at any other
time during an organism’s life. Biological Physics of the Developing Embryo presents
a framework within which physics can be used to analyze these biological
Written to be accessible to both biologists and physicists, major stages
and components of biological development are introduced and then analyzed
from the viewpoint of physics. The presentation of physical models requires no
mathematics beyond basic calculus.
Many families experience the challenges of caregiver depression and early childhood developmental delays. This tool kit provides information and resources for implementing depression screening within the early intervention system, strengthening cross-system collaborations, and implementing relationship-based care that focuses on the parent-child relationship in the early intervention and behavioral health systems.
Discovery of a new chemical entity that exerts pharmacological effects for
curing or treating diseases or relieving symptoms is only the first step in
the drug developmental process. In the developmental cycle of a new
drug, the delivery of a desired amount of a therapeutic agent to the target
at a specific time or duration is as important as its discovery. In order
to realize the optimal therapeutic outcomes, a delivery system should
be designed to achieve the optimal drug concentration at a predetermined
rate and at the desired location....
Prion diseases are characterized by the accumulation of a pathogenic mis-folded form of a prion protein (PrP) encoded by the Prnpgene in humans.
In the present study in zebrafish, two transcripts and the corresponding
genes encoding prion proteins, PrP1 and PrP2, related to human PrP have
been characterized with a relatively divergent deduced amino acid
sequence, but a well preserved overall organization of structural prion pro-tein motifs.
Molecular biology is the study of biology at a molecular level. This field overlaps with other areas of biology, particularly with genetics and biochemistry. Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationship of DNA, RNA, and protein synthesis and learning how these interactions are regulated.
The concept of 'biotech' or 'biotechnology' encompasses a wide range of procedures (and history) for modifying living organisms according to human purposes — going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies.
Biotechnology (sometimes shortened to "biotech") is generally accepted as the use of living systems and organisms to develop or make useful products, or "any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity) . For thousands of years, humankind has used biotechnology in agriculture, food production and medicine. The term itself is largely believed to have been coined in 1919 by Hungarian engineer Karl Ereky.
When an infection occurs, immune cells flock to the area and secrete large amounts of
highly reactive chemicals to combat the invader. But, these inflammatory chemicals
also attack normal tissue surrounding the infection and damage critical components of
cells, including DNA. During chronic inflammation, DNA damage may lead to
mutations or cell death and even to cancer and other diseases.
The concept of tissue engineering is to
regenerate target tissue by mimicking the developmental or regenerative process of that
tissue. Thus, it can be considered an ideal therapeutic option for treating various tissue
defects. Tissue engineering of skin, cartilage, and bone has already been shown both feasible
and effective in several clinical studies, and its efficacy has attracted significant attention
from both patients and doctors.
Since Kant, philosophy has been obsessed with epistemological questions pertaining to the relationship between mind and world and human access to objects. In The Democracy of Objects Bryant proposes that we break with this tradition and once again initiate the project of ontology as first philosophy. Drawing on the object-oriented ontology of Graham Harman, as well as the thought Roy Bhaskar, Gilles Deleuze, Niklas Luhman, Aristotle, Jacques Lacan, Bruno Latour and the developmental systems theorists, Bryant develops a realist ontology that he calls “onticology”.
Such a comprehensive model allows
for the modeled deposition of submicrometer aerosols (nanosized particles and
particulate matter sizes larger that nano to determine the total deposition as well as
localized deposition of particles). The results are important, prospectively, since they
may lead to a better understanding of the developmental respiratory physiology and
the associated effects on children’s health response to environmental pollutants, or the
medical outcome from inhalation therapy for infants and children from nanoparticlecontaining
Providing the board conducted one, the previous year’s executive performance eval-
uation most likely includes an action plan for the current year, with developmental
goals for the executive. Include these in the evaluation; if not attended to, an excel-
lent reason needs to be provided.
The executive job description should list major areas for which the executive is respon-
sible. It’s essential that the board review this in preparation for the job evaluation, espe-
cially if your board has never evaluated its director.
Part of the total estimated eligible expenses must be financed from sources other than the
Union grant. Applicants must indicate the sources and amounts of any other funding received
or applied for in the same financial year for the implementation of the project or work
The beneficiary shall supply evidence of the co-financing provided, either by way of own
resources, or in the form of financial transfers from third parties, or in kind.
(BQ) Part 1 book "Netter's atlas of human embryology" presents the following contents: An overview of developmental events, processes and abnormalities, early embryonic development and the placenta, the nervous system, the cardiovascular system, the respiratory system.
(BQ) Part 1 book "Rubin's pathology - Clinicopathologic foundations of medicine" presentation of content: Cell adaptation, injury and death; inlammation; repair, regeneration and fibrosis; developmental and genetic diseases, hemodynamic disorders, systemic autoimmune diseases, obesity and diabetes mellitus, the amyloidoses,... and other contents.
Several acute lymphoblastic and myelogenous leukemias are correlated with
alterations in the human mixed lineage leukemia protein-1 (MLL1) gene.
MLL1 is a member of the evolutionarily conserved SET1 family of histone
H3 lysine 4 (H3K4) methyltransferases, which are required for the regula-tion of distinct groups of developmentally regulated genes in metazoans.
The authors examined the online construction of identity and sexuality in a large sample of conversations from
monitored and unmonitored teen chat rooms. More than half of the 583 participants (identified by a distinct
screen name) communicated identity information, most frequently gender. In this way, participants compensated
for the text-based chat environment by providing information about themselves that would be visible and
obvious in face-to-face communication.
Ephrin receptor tyrosine kinase A3 (EphA3, EC 126.96.36.199) is a member of a
unique branch of the kinome in which downstream signaling occurs in both
ligand- and receptor-expressing cells. Consequently, the ephrins and ephrin
receptor tyrosine kinases often mediate processes involving cell–cell con-tact, including cellular adhesion or repulsion, developmental remodeling
and neuronal mapping.