During cell intoxication by diphtheria toxin, endosome acidification trig-gers the translocation of the catalytic (C) domain into the cytoplasm. This
event is mediated by the translocation (T) domain of the toxin. Previous
work suggested that the T domain acts as a chaperone for the C domain
during membrane penetration of the toxin.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài:
Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences
Pathogenesis and Immunology
Diphtheria toxin, produced by toxigenic strains of C. diphtheriae, is the primary virulence factor in clinical disease. The toxin is synthesized in precursor form; is released as a 535-amino-acid, single-chain protein; and has an LD50 of ~100 ng/kg of body weight. The toxin is produced in the pseudomembranous lesion and is taken up into the bloodstream, through which it is distributed to all organ systems.
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report...
The translocation domain (T domain) of diphtheria toxin adopts a partially
folded state, the so-called molten globule state, to become functional at
acidic pH. We compared, using hydrogen⁄deuterium exchange experiments
associated with MS, the structures of the T domain in its soluble folded
state at neutral pH and in its functional molten globule state at acidic pH.
A detailed proteolysis study of internalized diphtheria toxin (DT) within
rat liver endosomes was undertaken to determine whether DT-resistant
species exhibit defects in toxin endocytosis, toxin activation by cellular
enzymes or toxin translocation to its cytosolic target.
Harrison's Internal Medicine Chapter 131. Diphtheria and Other Infections Caused by Corynebacteria and Related Species
Corynebacterium diphtheriae. Toxigenic strains of C. diphtheriae produce a protein toxin that causes systemic toxicity, myocarditis, and polyneuropathy. The toxin is associated with the formation of pseudomembranes in the pharynx during respiratory diphtheria. While toxigenic strains most frequently cause pharyngeal diphtheria, nontoxigenic strains commonly cause cutaneous disease.
Diphtheria is a nasopharyngeal and skin infection caused by Corynebacterium diphtheriae. Toxigenic strains of C. diphtheriae produce a protein toxin that causes systemic toxicity, myocarditis, and polyneuropathy. The toxin is associated with the formation of pseudomembranes in the pharynx during respiratory diphtheria. While toxigenic strains most frequently cause pharyngeal diphtheria, nontoxigenic strains commonly cause cutaneous disease.
TB spreads through the air from one person to another. The bacteria are put into the air
when a person with active TB disease of the lungs or throat coughs or sneezes. People
nearby may breathe in these bacteria and get infected. When a person breathes in TB
bacteria, which may settle in the lungs and begin to grow. From there, they can move
through the blood to other parts of the body, such as the kidney, spine, and brain. TB in the
lungs or throat can be infectious. This means that the bacteria can spread to other people. TB...
The ADP-ribosylating toxins (ADPRTs) are a family of toxins that cata-lyse the hydrolysis of NAD and the transfer of the ADP-ribose moiety
onto a target. This family includes many notorious killers, responsible
for thousands of deaths annually including: cholera, enterotoxic Escheri-chia coli, whooping cough, diphtheria and a plethora of Clostridialbinary
Approaches to Passive Immunization Passive immunization is generally used to provide temporary immunity in a person exposed to an infectious disease who has not been actively immunized; this situation can arise when active immunization is unavailable (e.g., for respiratory syncytial virus) or when active immunization simply has not been implemented before exposure (e.g., for rabies). Passive immunization is used in the treatment of certain illnesses associated with toxins (e.g.