Xem 1-20 trên 85 kết quả Discovery process
  • The discovery of efficacious new human therapeutic agents is one of humanity’s most vital tasks. It is an enormously demanding activity that requires creativity, a vast range of scientific knowledge, and great persistence. It is also an exceedingly expensive activity. In an ideal world, no education would be complete without some exposure to the ways in which new medicines are discovered and developed. For those young people interested in science or medicine, such knowledge is arguably mandatory....

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  • Great efficiencies have been achieved in the drug discovery process as a result of technological advances in target identification, high-throughput screening, high-throughput organic synthesis, just-in-time in vitro ADME (absorption, distribution, metabolism, and excretion), and early pharmacokinetic screening of drug leads. These advances, spanning target selection all the way through to clinical candidate selection, have placed greater and greater demands on the analytical community to develop robust high-throughput methods.

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  • The modern drug discovery process, in general, involves the identification of a biochemical target (usually protein target), screening of synthetic compounds or compound libraries from combinatorial chemistry/natural sources for a lead compound, and optimization of the lead compound (activity, selectivity, pharmacokinetics, etc.) for recommending a potential clinical candidate.

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  • Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs.

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  • We describe a joint model for understanding user actions in natural language utterances. Our multi-layer generative approach uses both labeled and unlabeled utterances to jointly learn aspects regarding utterance’s target domain (e.g. movies), intention (e.g., finding a movie) along with other semantic units (e.g., movie name). We inject information extracted from unstructured web search query logs as prior information to enhance the generative process of the natural language utterance understanding model....

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  • We present Wikulu1 , a system focusing on supporting wiki users with their everyday tasks by means of an intelligent interface. Wikulu is implemented as an extensible architecture which transparently integrates natural language processing (NLP) techniques with wikis. It is designed to be deployed with any wiki platform, and the current prototype integrates a wide range of NLP algorithms such as keyphrase extraction, link discovery, text segmentation, summarization, or text similarity.

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  • Acquisition of phonological s y s t e m s can be insightfully studied in t e r m s of discovery procedures. T h i s paper describes a discovery procedure, i m p l e m e n t e d in Lisp, capable of determining a set of ordered phonological rules, which m a y be in opaque contexts~ from a set of surface forms arranged in paradigms.

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  • The following will be discussed in this chapter: Identify the characteristics of distance vector routing protocols, describe the network discovery process of distance vector routing protocols using Routing Information Protocol (RIP), describe the processes to maintain accurate routing tables used by distance vector routing protocols,...

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  • Named Entity recognition (NER) is an important part of many natural language processing tasks. Current approaches often employ machine learning techniques and require supervised data. However, many languages lack such resources. This paper presents an (almost) unsupervised learning algorithm for automatic discovery of Named Entities (NEs) in a resource free language, given a bilingual corpora in which it is weakly temporally aligned with a resource rich language.

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  • In this chapter: Identify the characteristics of distance vector routing protocols, describe the network discovery process of distance vector routing protocols using Routing Information Protocol (RIP), describe the processes to maintain accurate routing tables used by distance vector routing protocols,...

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  • 4.2.3 MTMF MTMF combines the best parts of the Linear Spectral Mixing model and the statistical Matched Filter model while avoiding the drawbacks of each parent method (Boardman, 1998). It is a useful Matched Filter method without knowing all the possible endmembers in a landscape especially in case of subtle, sub-pixel occurrences. Firstly, pixel spectra and endmember spectra require a minimum noise fraction (MNF) (Green et al., 1988, Boardman, 1993) transformation. MNF reduces and separates an image into its most dimensional and non-noisy components.

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  • Distance Vector Routing Protocols Objectives: Identify the characteristics of distance vector routing p y g protocols. Describe the network discovery process of distance vector routing protocols using Routing Information Protocol (RIP). Describe the processes to maintain accurate routing tables used by distance vector routing protocols. Identify the Id tif th conditions l di t a routing l diti leading to ti loop and explain th d l i the implications for router performance. Recognize that distance vector routing protocols are in use today. ...

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  • This book is a straightforward discussion of the concepts, principles, and processes of Internet Protocol version 6 (IPv6) and how it is supported by the Microsoft Windows Server 2008 and Windows Vista operating systems. Note that this book does not contain programming code-level details of the IPv6 protocol for Windows Server 2008 and Windows Vista, such as structures, tables, buffers, or coding logic. These details are highly guarded Microsoft intellectual property that is of interest only to a relative handful of software developers.

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  • Worldwide, crude oil demand is unceasingly increasing. As a response, Enhanced Oil Recovery (EOR) processes have re‐gained interest from the research and development phases to the oilfield EOR implementation stage. This renewed interest has been also furthered by the current high oil price environment, the maturation of oilfields worldwide, and few new‐well discoveries. Concurrently, environmental concerns and public pressure related to crude oil pollution control and remediation of oilcontaminated sites are becoming greater than ever....

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  • Identify the characteristics of distance vector routing p y g protocols. Describe the network discovery process of distance vector routing protocols using Routing Information Protocol (RIP). Describe the processes to maintain accurate routing tables used by distance vector routing protocols.

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  • The following chapter is designed to be a ready reference to legal procedure, terminology, and sequence of events in a civil case. All information is from the perspective of the expert, so that he may be properly prepared at every stage.

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  • Identify the characteristics of distance vector routing p y g protocols. Describe the network discovery process of distance vector routing protocols using Routing Information Protocol (RIP). Describe the processes to maintain accurate routing tables used by distance vector routing protocols. Identify the Id tif th conditions l di t a routing l diti leading to ti loop and explain th d l i the implications for router performance.

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  • Recent DCF analysis highlighted the importance of improved national aid information management systems to better track effective development cooperation targets, including on gender equality and the empowerment of women, and to make a wide range of timely and forward-looking information (on disbursements, forecasts, progress on results, and gender issues) widely available to all stakeholders for accountability purposes.

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  • With this new edition of Effective Expert Witnessing, Dr. Matson has added new information that is critical to expert witnessing in the late 1990s. In the decade since the first edition of this book was published, expert witnessing has been transformed by a series of court rulings generally concerned with the reliability, relevancy, and admissibility of expert testimony. Expert witnessing and trial strategy have not been the same since these decisions.

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  • In the drug discovery area, a compound with desired therapeutic properties is identified, and its structure may be modified by synthetic alterations to enhance potency and specificity or to decrease toxicity and undesired side effects. The lead drug candidate is then transitioned into the drug development area. Only small amounts of drug (typically less than a gram) are required to support the required studies in the Drug Discovery area. However larger amounts are required to support the studies conducted in the Drug Development area.

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