Disease gene prioritization

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  • The theoretical manner in which periodontal disease progresses has long been a subject of debate. It is currently agreed that destructive periodontal disease progresses by means of asynchronous bursts of activity (Haffajee and Socransky 1986). According to this theory, periodontal tissue support is lost during short, acute episodes followed by prolonged periods of quiescence (Reddy, Palcanis, and Geurs 1997).

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  • Chlorophyll fluorescence represents an intrinsic signal emitted by plants that can be employed to monitor their physiological state including changes of the photosynthetic apparatus, developmental processes of leaves, state of health, stress events, stress tolerance, and also to detect diseases or nutrient deficiency of plants. In particular, the application of laser induced chlorophyll fluorescence spectroscopy has drawn much attention recently owing to the non-invasive and nondestructive nature of the technique (Svanberg, 1995; Lang & Lichtenthaler, 1991; Chappelle et al., 1984)....

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  • This paper focuses on developing an empirical strategy for measuring the effect of pollution on health. Specifically, I look at the effect of air pollution on children's hospitalization for asthma. Childhood asthma is of particular interest for two reasons: 1) asthma is the leading chronic condition affecting children; and 2) current pollution standards are based on adult health responses to pollution and children face a greater risk from pollution exposure due to the sensitivity of their developing biological systems. This study builds on earlier work in five ways.

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  • Reduced levels of clinical or radiological pneumonia in clin- ical trials of a nine-valent pneumococcal conjugate vaccine provide an estimate of the vaccine-preventable disease burden (valency indicates the number of serotypes against which the vaccine provides protection; conjugate refers to conjugation of polysaccharides to a protein backbone). In a study in The Gambia, 37 percent of radiological pneumonia was prevented, reflecting the amount of disease caused by S. pneumoniae, and mortality was reduced by 16 percent (Cutts and others 2005).

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  • Parkinson’s disease is the second most common neurodegenerative disorder. The pathological hallmark of the disease is degeneration of midbrain dopaminergic neurons. Genetic association studies have linked 13 human chromosomal loci to Parkinson’s disease. Identification of gene(s), as part of the etiology of Parkinson’s disease, within the large number of genes residing in these loci can be achieved through several approaches, including screening methods, and considering appropriate criteria.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network...

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  • Furthermore, in order to boost innovative drugs and health solutions in Europe the Health Theme makes a major effort into investigator-driven clinical trials in various fields. With a focus on brain-related diseases, diabetes, and cancer (incorporating life style issues and social determinants of health) the 2011 work programme addresses major health-related societal challenges. Finally, with a focus on antimicrobial drug resistance and emerging epidemics, the Health Theme continues to address global health issues of utmost importance.

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  • Such pesticides are widely used agricultural inputs, and they are esters of the phosphoric acid and the derivates thereof, and they share in common as a pharmacological characteristic, the action of inhibiting enzymes having esteracic activities, and more specifically, the inhibition of the acetylcholinesterase. They are easily hydrolyze and they have a low capacity of remaining in the environment (Palacios and Moreno, 2004), (Chakraborty, 2009), (Ntow et al, 2009). Other pesticides under study are the organochlorated, which are persistent, lypophilic and very steady.

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  • An extended range of new sensing applications and solutions have emerged in different fields such as rural and forest fire detection [1], monitoring of industrial manufacturing processes [2], transport/logistics [3], and for personal services in areas such as healthcare and Ambient Assisted Living (AAL) [4]. These new advanced applications based on a new generation of sensing and communication capabilities are a consequence of the continuous advances in sensor technologies and wireless communication protocols that allow for greater autonomy of sensor nodes.

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  • All cacac aspects of human and robotic elements within the research activities of HRI far as they provide insight into how to improve our understanding of the development effective tools, protocols, and systems to enhance the HRI. For example, significant research efforts are being devoted to the man-machine interface design which makes it easier for people to interact with the robot. Researchers are investigating how to improve the existing interface so that multiple users can interact with multiple risk program at the same time.

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  • The importance of sustainable management of non-market forest goods and services has increased during the last few years. This is also reflected in a number of policy documents within the EU. The new EU Rural Development Regulation speaks about the “non-productive investments", as investments to enhance the public amenity value of forests. The stakeholder consultation process within the EU Forestry Strategy and the report of the strategy’s implementation identify the issue of creating markets for currently non-market forest goods and services as an emerging issue.

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  • Our stylized model generates several empirical hypotheses about the insurance offer decision. Firms in industries where labor turnover rates are high do not tend to offer insurance. Premium rigidities will be most pronounced in such industries. Firms not offering insurance will tend to have lower health-cost variability and lower average expected health spending than firms offering insurance; for example, they have higher proportions of younger workers or are in industries where workers tend to be healthy.

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  • While the aesthetic and creative process of interior design would best be done by professional interior designers, our goal is to cre- ate software capable of automatically generating furniture arrange- ments for complex indoor scenes that are optimized to respect im- portant ergonomic factors. This technique would be useful in multi- player online games and other graphics applications requiring fully automatic interior design with a high degree of realism.

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  • The narrative behind Simplified Ecosystem Capital Accounts (SECA): Ecosystems can be described as capital which delivers a bundle of services to people, some of which are appropriated and incorporated into products, accumulated and/or consumed. Other services are public goods of common benefit to the economy and human wellbeing. Altogether, these ecosystem services depend on ecosystem capital regeneration which is in turn influenced by ecosystem services consumption.

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  • Tham khảo tài liệu 'diary of a wimpy kid event kit', kinh doanh - tiếp thị, tổ chức sự kiện phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • A breakdown by diagnosis shows even greater inequities: for women only 21% of the assessed musculoskeletal disorders’ claims were approved compared to 38% for men. For mental illness, only 12% of the women’s claims were accepted against 35% for the men’s. Data from Quebec, Canada, show similar inequities for stress-related claims and those for musculoskeletal disorders (Lippel, 1999, 2003); however an examination of claims related to workplace violence showed an advantage for women (Lippel, 2001).

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  • There are, actually, no formal Swedish regulations for organic contaminants in sludge. There is an informal agreement between the Swedish EPA, the Farmers Union and the Water and Wastewater Association which includes the recommendations in table 3.1-1. These agreements are based more on practical experience than on scientific data. Sweden also used to have a recommended limit value for toluene, but this has been omitted (WALLGREN 2001).

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  • Without doubt, improving the education system to support Māori students to achieve their full potential is a big and complex challenge. For most of us, it is too big to know where to start. During our scoping work for this report, we decided on some questions that we consider make this challenge more digestible.

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  • Initially, buying green power in competitive retail markets entailed switching electricity service from the incumbent utility to a green power supplier. However, with few exceptions, green power marketers have found it difficult to compete or to persuade customers to switch suppliers. As a remedy, a number of states now require default suppliers (which are often the incumbent distribution utilities) to offer green power options to their customers.

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  • For reference purposes, I’ll mention some of the common ways to document requirements and planning information. If nothing else, knowing the common lingo helps translate between the various methods used by different organizations. You’ll find some teams document the requirements informally: “Oh, requirements…just go talk to Fred.” Others have elaborate templates and review procedures that break these documents into insanely small (and possibly overlapping) pieces owned by different people. • Marketing requirements document (MRD).

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