Disease markers

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  • Cardiovascular disease, including coronary heart disease, strokes and diseases of other arteries, is a major cause of early death and disability. For many years the major markers of disease risk have been well recognised: these include high blood cholesterol levels and smoking. But it has also been recognised that these markers do not account for all cardiovascular risk. Furthermore, treatments that are highly effective in altering these markers, for instance the ‘statin’ drugs used to lower cholesterol, do not remove risk entirely: typically they reduce it by about 30% or less.

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  • Cervical cancer is the second most prevalent cancer among women worldwide, and infection with Human Papilloma Virus (HPV) has been identified as the causal agent for this condition. The natural history of cervical cancer is characterized by slow disease progression, rendering the condition in essence preventable and even treatable when diagnosed in early stages.

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  • These women are characterized by alterations in the lipid profile, amplification of the inflammatory process, elevated oxidative stress and endothelial dysfunction as well as cardiovascular disease later in life, all of which comprise aspects of the same disease spectrum. Finally, Chapter 18 comprises an article offering an overview of bioethics given that, in the past few decades, the domain of health care has placed ever more emphasis on the necessity to defend and advance women’s sexual and reproductive rights.

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  • Chronic Idiopathic Myelofibrosis Chronic IMF (other designations include agnogenic myeloid metaplasia or myelofibrosis with myeloid metaplasia) is a clonal disorder of a multipotent hematopoietic progenitor cell of unknown etiology characterized by marrow fibrosis, extramedullary hematopoiesis, and splenomegaly. Chronic IMF is the least common chronic myeloproliferative disorder, and establishing this diagnosis in the absence of a specific clonal marker is difficult because myelofibrosis and splenomegaly are also features of both PV and CML.

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  • Few studies have simultaneously investigated the role of soluble tumor necrosis factor a (TNFa ) receptors types 1 and 2 (sTNF-R1 and sTNF-R2), C-reactive protein, and interleukin-6 as predictors of cardiovascular events. The value of these inflammatory markers as independent predictors remains controversial.

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  • That idea gets a firm nod from therapist Lisa Lieberman. “It’s important not to parentify kids,” she says. They may learn more responsibility, but they need permission to be kids, have friends and be normal in that respect. “They are not there to be in charge of everything. They need to have some of the carefree spirit of being a kid.” There is a fine line between developing an appropriate sense of responsibility — not pretending that things aren’t any different — and putting too much onto their shoulders.

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  • The all-too-common conditions this woman and her children face illustrate how health programs and weak systems in many developing countries are not meeting needs. Although health services may be available, too often they are of poor quality and are provided in an uncoordinated or ad hoc manner. Often, they are organized around funding sources or diseases, rather than in a way that addresses the broader needs of the populations they seek to serve.

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  • Services’ Offi ce on Women’s Health and the Centers for Disease Control and Prevention’s National Center for Health Statistics as a tool to help identify vulnerable and underserved populations at the state level, where most decisions regarding health policy are developed and implemented. While the project provides data on health, health care, and risk behavior on all populations in each state for which data are collected, women’s health concerns have been targeted for inclusion, and racial and ethnic differences among women are a primary focus.

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  • Ischemic heart disease continues to be the leading cause of morbidity and mortality in both developed and developing countries, and remains one of the most important public health problems. The continuous rise in the prevalence of disorders such as obesity, diabetes, dyslipidemia and hypertension is driving the ever-increasing number of incidences of ischemic heart disease.

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  • Breast cancer remains a leading cause of cancer death among women in the United States. More than 180,000 new cases of invasive breast cancer are diagnosed each year, and more than 40,000 women die of the disease. Recent years, however, have seen improvements in survival attributed to better treatment and earlier diagnosis. Research efforts have been directed toward better treatment, preventive strategies, and early detection.

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  • The incidence of cardiovascular disease has decreased in the last several years with a better understanding of the pathophysiology of acute coronary syndromes (ACS), widespread implementation of lipid lowering drugs, improved surgical treatments such as stent placements, and new therapeutic regimens such as the statins, low molecular weight heparins, and platelet glycoprotein IIb/IIIa receptor inhibitors. Nevertheless, it remains today as the leading cause of morbidity and mortality in the Western world....

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  • Endometrial, cervical, and ovarian cancers are the three most common malignancies of the female reproductive tract. In the United States alone, roughly 12,000 women are diagnosed with uterine cervical cancer annually, and 4,000 will die from the disease [1]. The relatively low incidence of cervical cancer in the US is largely attributable to the effectiveness of Papanicolaou’s cytological cervical screening test (the Pap test).

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  • The mechanisms accounting for poor expression of the BCR in CLL remain elusive. There is no evidence of genetic defects in the BCR components [62, 63] and in contrast with their poor expression at the membrane level, transcription and intra-cellular synthesis of BCR components are normal [63, 64]. However, they cannot be assembled and transported from the endoplasmic reticulum to the cell surface because of a folding and glycosolation defect of the mu and CD79a chains though not of the CD79b chain.

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  • This study has focused on cardio-respiratory illnesses caused by the principal components of smog, namely ozone and air-borne particulate matter. 2 Smog consists of a complex “soup” of pollutants, some of which may cause human health problems directly and others which may be precursors to causal contaminants or which are closely correlated with causal contaminants and hence act as “markers” for human health risks. The complexities associated with the cause/effect relationships between this soup of pollutants and human health are explored in this report.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease

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