Coronary heart disease is the leading cause of death worldwide,
and 3.8 million men and 3.4 million women die of the disease each
year. After an acute myocardial infarction, early and successful myocardial
reperfusion with the use of thrombolytic therapy or primary percutaneous coronary
intervention (PCI) is the most effective strategy for reducing the size of a myocardial
infarct and improving the clinical outcome. The process of restoring blood
flow to the ischemic myocardium, however, can induce injury.
Therapy of Selected Diseases
crease in arteriolar resistance, ensuring adequate myocardial perfusion. During exercise, further dilation of arterioles is impossible. As a result, there is ischemia associated with pain. Pharmacological agents that act to dilate arterioles would thus be inappropriate because at rest they may divert blood from underperfused into healthy vascular regions on account of redundant arteriolar dilation. The resulting “steal effect” could provoke an anginal attack. (3) The intramyocardial pressure, i.e., systolic squeeze, compresses the capillary bed.
Effective new treatments of heart disease are based on a refined understanding of
cellular function and the heart's response to environmental stresses. Not surprisingly
therefore, the field of experimental cardiology has experienced a phase of rapid exponential
growth during the last decade. The acquisition of new knowledge has been so
fast that textbooks of cardiology or textbooks of cardiovascular physiology are often
hard-pressed to keep up with the most important conceptual advances.
An association between exposure to vehicular traffic in urban areas and the exacerbation
of cardiovascular disease has been suggested in previous studies. This study was
designed to assess whether exposure to traffic can trigger myocardial infarction.
We conducted a case–crossover study in which cases of myocardial infarction were
identified with the use of data from the Cooperative Health Research in the Region of
Augsburg Myocardial Infarction Registry in Augsburg, in southern Germany, for the
period from February 1999 to July 2001....
In clinical practice left ventricular (LV) function is commonly
evaluated by 2-D and M-mode echocardiography.
These modalities have significant limitations,and tissue
Doppler imaging (TDI) has been introduced as a quantitative
and more objective method for assessing myocardial
function. The TDI modalities include myocardial
velocity imaging,displacement imaging,strain rate imaging,
and strain imaging (Fig. 1).
In patients with stable coronary artery disease, it remains unclear whether an initial
management strategy of percutaneous coronary intervention (PCI) with intensive
pharmacologic therapy and lifestyle intervention (optimal medical therapy) is superior
to optimal medical therapy alone in reducing the risk of cardiovascular events.
We conducted a randomized trial involving 2287 patients who had objective evidence
of myocardial ischemia and significant coronary artery disease at 50 U.S. and Canadian
Angiotensin-converting–enzyme (ACE) inhibitors are effective in reducing the risk of
heart failure, myocardial infarction, and death from cardiovascular causes in patients
with left ventricular systolic dysfunction or heart failure. ACE inhibitors have also been
shown to reduce atherosclerotic complications in patients who have vascular disease
without heart failure.
Pilot studies suggest that intracoronary transplantation of progenitor cells derived
from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular
function after acute myocardial infarction. The effects of cell transplantation in
patients with healed myocardial infarction are unknown.
Noninvasive Imaging of Myocardial Ischemia provides a comprehensive discussion and
review of the noninvasive myocardial imaging techniques that are currently available to
detect myocardial ischemia and infarction. Topics covered include echocardiography,
cardiac magnetic resonance imaging, myocardial perfusion scintigraphy, positron
emission tomography, and computed tomography.
Lecture Notes on Clinical Medicine has a long-standing reputation for excellence and is a must-have in the run-up to final examinations and throughout the clinical years. It offers a concise summary of the essential information needed for practising clinical medicine.
The book is divided into two sections: Part 1 focuses on the clinical examination of each body system, and Part 2 summarises the core knowledge required for the understanding of specific diseases relevant to each body system.
At the end of the lecture, participants will know: the epidemiology of coronary artery disease, the risk factors associated with coronary artery disease, how to use online tools to estimate a patient's risk for myocardial infarction, how to screen for and couns a patient to reduce their risk for coronary artery disease.
(BQ) Part 2 book "Advances in hemodynamic research" presents the following contents: Congenital heart disease and circulatory physiology, hemodynamics in coronary arterial disease and myocardial perfusion, application to cardiovascular surgery, reperfusion hemodynamics as an early predictor of cardiac function in a DCDD setting,...
(BQ) Part 2 book "Coronary artery disease - Assessment, surgery, prevention" presents the following contents: Coronary artery bypass surgery, surgical treatment in diffuse coronary artery disease, role and rationale for hybrid coronary artery revascularization, mechanical complications of myocardial infarction, prevention of coronary artery disease through diet,...
Diabetes is a unique condition for women. When compared with men,
women have a 50 percent greater risk of diabetic coma, a condition brought on
by poorly controlled diabetes and lack of insulin. Women with diabetes have
heart disease rates similar to men, but more women with diabetes die from a
first heart attack than do men with diabetes. Diabetes also poses special
challenges during pregnancy.
Hypertension and coronary heart disease (CHD) are of great importance. Hypertension affects above 20% of the total population of the USA with its major impact on those over age 50. CHD is the cause of death in 30% of males and 22% of females in England and Wales. Management requires attention to detail, both clinical and pharmacological. The way drugs act in these diseases is outlined and the drugs are described according to class.
1/ BỆNH TIM DO THIẾU MÁU CỤC BỘ CẤP TÍNH ĐƯỢC XẾP LOẠI NHƯ THẾ NÀO ? 1. Bệnh tim do thiếu máu cục bộ ổn định mãn tính 2. Các hợp chứng động mạch vành cấp tính (Acute coronary syndromes) a. Cơn đau thắt ngực không ổn định (unstable angina) b. Nhồi máu cơ tim cấp tính không nâng cao đoạn ST (Acute non-ST segment elevation myocardial infarction)
We have compiled and written this textbook to highlight the clinical indications and
applications of cardiac magnetic resonance imaging (MRI). Over the past few decades,
MRI has become an essential element of decision making for many medical specialties.
However, though cardiovascular diseases are a major cause of morbidity and mortality
throughout the world, MRI of the heart and great vessels has experienced relatively slow
1/ BỆNH TIM DO THIẾU MÁU CỤC BỘ CẤP TÍNH ĐƯỢC XẾP LOẠI NHƯ THẾ NÀO ?
Bệnh tim do thiếu máu cục bộ ổn định mãn tính. (Chronic stable ischemic heart disease)
Các hợp chứng động mạch vành cấp tính. (Acute coronary syndromes)
Cơn đau thắt ngực không ổn định (unstable angina) Nhồi máu cơ tim cấp tính không nâng cao đoạn ST.(Acute non-ST segment elevation myocardial infarction)
The mortality from ischemic heart disease has decreased in recent years. The better under‐
standing of risk factors associated with development of coronary artery disease (CAD) has
significantly contributed to this decline. Preventive measures such as aggressive therapy of
arterial hypertension, diabetes mellitus, and lipid disorders and by campaigning against the
smoking are important components of this medical success.