Autoimmune disease represents a group of more than 60 different chronic autoimmune
diseases that affect approximately 6% of the population. It is the third major category of
illness in the United States and many industrialized countries, following heart disease
and cancer. Autoimmune diseases arise when one’s immune system actively targets and
destroys self tissue resulting in clinical disease. Common examples include Systemic
Lupus Erythematosus, Type 1 Diabetes, Rheumatoid Arthritis and Multiple Sclerosis.
Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life‐long disorder. It is
characterized by inflammation in the small intestine of genetically predisposed
individuals caused by inappropriate immune response to gluten, a protein enriched in
some of our common grains (wheat, rye and barley). The toxicity of gluten is
manifested by the autoimmune action of T‐lymphocytes on mucosal cells in the small
intestine, disrupting its vital function of absorbing nutrients from food.
Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis...
Tham khảo luận văn - đề án 'báo cáo y học: " vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (als), with a potential role in disease pathogenesis"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Infectious Disease: Pathogenesis, Prevention, and Case Studies...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The contribution of activated astrocytes to Ab production: Implications for Alzheimer’s disease pathogenesis
There is great difficulty, in the case of a subject so large and complex as is disease, in giving a definition
which will be accurate and comprehensive. Disease may be defined as "A change produced in living things in
consequence of which they are no longer in harmony with their environment." It is evident that this
conception of disease is inseparable from the idea of life, since only a living thing can become diseased.
The subject of preventive medicine is one that is attracting world-wide attention to-day. We can hardly pick
up a newspaper or magazine without seeing the subject discussed in some of its phases, and during the last
few years several books have appeared devoted wholly or in part to the ways of preventing rather than curing
many of our ills.
Looking over the titles of these articles and books the reader will at once be impressed with the importance
that is being given to the subject of the relation of insects to some of our common diseases.
Use of Fungi for Insect Control
- Issues, Developments & Research Needs
• Classification • Pathogenesis • Why fungi as BCA’s? • Commercialization
• Registration • Some examples • Research
Agriculture and Agriculture et Agri-Food Canada Agroalimentaire Canada
Central to the development of glomerular inflammation and injury are alterations and
abnormalities of various cytokines and signaling systems. There are four chapters in
this book that deal with these aspects in the pathogenesis. The role of TGF-β in
progressive glomerular disease is discussed in great detail in a chapter well written by
Hyun Soon Lee, with particular reference to mesangial matrix accumulation, while the
role of STAT3 activation in glomerulonephritis is elaborated in the well written
chapter by Fumio Tsuji et al.
Harrison's Internal Medicine Chapter 114. Molecular Mechanisms of Microbial Pathogenesis
Molecular Mechanisms of Microbial Pathogenesis: Introduction
Over the past three decades, molecular studies of the pathogenesis of microorganisms have yielded an explosion of information about the various microbial and host molecules that contribute to the processes of infection and disease.
Encounters with Epithelial Cells
Over the past decade, many bacterial pathogens have been shown to enter epithelial cells (Fig. 114-2); the bacteria often use specialized surface structures that bind to receptors, with consequent internalization. However, the exact role and the importance of this process in infection and disease are not well defined for most of these pathogens. Bacterial entry into host epithelial cells is seen as a means for dissemination to adjacent or deeper tissues or as a route to sanctuary to avoid ingestion and killing by professional phagocytes.
Encounters with Phagocytes
Phagocytosis and Inflammation Phagocytosis of microbes is a major innate host defense that limits the growth and spread of pathogens. Phagocytes appear rapidly at sites of infection in conjunction with the initiation of inflammation. Ingestion of microbes by both tissue-fixed macrophages and migrating phagocytes probably accounts for the limited ability of most microbial agents to cause disease.
Many diseases are caused primarily by pathogens growing in tissue sites that are normally sterile. Pneumococcal pneumonia is mostly attributable to the growth of S. pneumoniae in the lung and the attendant host inflammatory response, although specific factors that enhance this process (e.g., pneumolysin) may be responsible for some of the pathogenic potential of the pneumococcus. Disease that follows bacteremia and invasion of the meninges by meningitisproducing bacteria such as N. meningitidis, H. influenzae, E.
Transmission to New Hosts
As part of the pathogenic process, most microbes are shed from the host, often in a form infectious for susceptible individuals. However, the rate of transmissibility may not necessarily be high, even if the disease is severe in the infected individual, as transmissibility and virulence are not linked traits.
The etiology of PV is unknown. Although nonrandom chromosome abnormalities such as 20q, trisomy 8, and especially 9p, have been documented in up to 30% of untreated PV patients, unlike CML no consistent cytogenetic abnormality has been associated with the disorder. However, a mutation in the autoinhibitory, pseudokinase domain of the tyrosine kinase JAK2—which replaces valine with phenylalanine (V617F), causing constitutive activation of the kinase— appears to have a central role in the pathogenesis of PV.
The human body as a mechanism is far from perfect. It can be beaten or surpassed at almost every point by
some product of the machine-shop or some animal. It does almost nothing perfectly or with absolute
precision. As Huxley most unexpectedly remarked a score of years ago, "If a manufacturer of optical
instruments were to hand us for laboratory use an instrument so full of defects and imperfections as the human
eye, we should promptly decline to accept it and return it to him. But," as he went on to say, "while the eye is
inaccurate as a microscope, imperfect as a telescope, crude...
Background: Dercum’s disease (DD) is characterised by obesity and chronic pain ( 3 months) in the adipose tissue. The pathogenesis of DD is unknown, but inflammatory components have been proposed. In previous reports and studies, an inconsistent picture of the histological appearance of the adipose tissue in DD has been described. The aim of this investigation was to examine the histological appearance of adipose tissue in patients with DD, with particular focus on inflammatory signs. Methods: Fat biopsies were sampled from painful regions from 53 patients with DD.
The quantity of adenovirus-DNA decreases in an age-
related manner, either from immune elimination or from depletion of latent stores.
Persistent or latent infection of other species is still unknown.
Acute renal failure due to adenoviruses is caused by disseminated disease or retrograde
infection from hemorrhagic cystitis. High persistence of serotype 2 at a young age is
mentioned in lots of case reports regarding disseminated diseases of this serotype after stem
In 1887, Anton Weichselbaum, a Viennese doctor, was the first to report the
isolation of meningococci from patients with meningitis (1). Shortly after, came
the first description of lumbar puncture in living patients (2), leading to the isolation
of meningococci from acute cases of meningitis. Three years later, Kiefer
grew meningococci from the nasopharynx of cases of meningococcal disease,
and from their contacts (3), a finding of immense significance in advancing
understanding of the epidemiology and pathogenesis of the disease.