During the annual meeting of the Medical Society of Athens on
November 15, 1930 Benediktos Adamantiades (1875-1962) (Fig. 1), Greek
ophthalmologist from Prussa, Asia minor (nowadays Bursa, Turkey)
presented in a lecture with the title ”A case of relapsing iritis with
hypopyon ”, a 20-year-old male patient with the three cardinal signs of the
disease. The disease had begun at the age of 18 with edema and ulcerations
at the left leg diagnosed as thrombophlebitis.
Demographic and epidemiological transitions and changes in lifestyle are leading to the
emergence of cancer and other chronic diseases as public health problems in India. Cancer
pattern in India reveals the predominance of tobacco related cancers, which are amenable
to primary prevention. Cancer Registries in different parts of the country reveal that majority
of cancer cases present in an advanced stage and makes treatment options prolonged and
This book is a labor of love. As the authors state, it is “a tale of two fathers.” The
father of Sylvia Karasu suffered from morbid obesity all of his life, together with
other risk factors for coronary heart disease, and lived to the age of 91. The father
of Byram Karasu, also morbidly obese, died at the age of 56. This tale of two fathers
is in the background of the volume as the authors seek to assess the many factors
that contribute to obesity and its control.
The Gravity of Weight is a model of scholarly inquiry that describes and analyzes,
in a critical manner,...
Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Efficacy of Sirolimus-Eluting Stents Compared With Paclitaxel-Eluting Stents in an Unselected Population With Coronary Artery Disease: 24-Month Outcomes of Patients in a Prospective Non-randomized Registry in Southern Turkey...
Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Two-year Outcome of Turkish Patients Treated with Zotarolimus Versus Paclitaxel Eluting Stents in an Unselected Population with Coronary Artery Disease in the Real World: A Prospective Non-randomized Registry in Southern Turkey...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)...
While many studies have focused on estimating a relationship between pollution and health, they
have largely neglected to consider that pollution exposure is endogenously determined if individuals make
choices to maximize their well-being. People with high preferences for clean air may choose to live in areas
with better air quality. People can respond to a wide range of readily available information on pollution
levels by adjusting their exposure. Failing to appropriately account for such actions can yield misleading
estimates of the causal effect of pollution on health. ...
Traditionally, health agencies determine potential adverse human health effects based on results of
published animal studies. It is difficult for many agencies to say for certain if a chemical is dangerous to
humans because there may be no published studies of human exposures.
Public health agencies examine all available data when evaluating chemicals.
Large EHR research databases are the key development that makes it possible to create a rapid learning health system. The VA and Kaiser Permanente are the public and private sector leaders; their new research databases each have more than 8 million EHRs. They are likely to add genomic information.
During the past year the Board was also active on the policy front, releasing a major report on ten
years of medical malpractice payments in Massachusetts, from 1994 to 2003. The Board also
directed its Patient Care Assessment unit to monitor and oversee the implementation of the
recommendations made in the Department of Public Health/Betsy Lehman Center report on
weight loss surgery.
Oates (62) investigated causes of death in women up to one year after giving birth in the UK and
came to the conclusion that during the period, 1997-1999, suicide was the leading cause of death
- responsible for 10% of all deaths. In 86% of the cases it was possible to make a psychiatric
diagnosis, indicating that 68% of women who committed suicide were suffering from a serious
illness (psychosis or severe depressive illness). Drife (63) observed similar results for the
period, 2000-2002. Austin et al.
CKD in children is the result of heterogeneous
diseases of the kidney and urinary tract that
range from common congenital malformations
of the urinary tract, to rare inborn errors of
metabolism that affect kidney function
is an irreversible condition that eventually
progresses to end stage renal disease (ESRD).
It is an important cause of morbidity and
mortality in children worldwide [2,3]
The rationale for the guideline is that whilst growth is documented in a proportion of those receiving
renal replacement therapy (published in the UK Renal Registry report) there is scope for improving
identification of growth failure in children at an earlier stage. Identification and treatment of nutritional
deficiencies and metabolic abnormalities should be aggressively pursued with respect to linear growth.
Recombinant human growth hormone (rhGH) should be considered if there is growth failure despite
the treatment of nutritional deficiencies and metabolic abnormalities
Active follow-up usually means that the registry attempts to contact physi-
cians or patients on a regular basis to see if the patient is still alive. Because
this is expensive, many registries rely on passive follow-up, matching with
death certificates and assuming patients are alive otherwise. Mixed systems
use death certificates plus updating the ‘date last known alive’ from hospital
admissions, consultations, and other sources of data.
Active follow-up of the patients is usually very difficult in developing coun-
The second requirement is a clear and well defined starting point. For popu-
lation-based cancer registries, the starting date (from which the survival is
calculated) is the incidence date (see Section 17.3.1).
The third requirement is a clear and well defined outcome. Death is gener-
ally the outcome of interest, but some registries collect enough data to allow
them to conduct analyses using recurrence of tumour, or first recurrence of
a particular complication, as the outcome of interest.
Large EHR research databases are the key development that makes it possible to create a rapid learning health system. The VA and Kaiser Permanente are the public and private sector leaders; their new research databases each have more than 8 million EHRs. They are likely to add genomic information. New networks with EHR databases—“virtual research organizations”—add even more to these capacities.
Sources of Evidence: Clinical Trials and Registries The notion of learning from observation of patients is as old as medicine itself. Over the last 50 years, our understanding of how best to turn raw observation into useful evidence has evolved considerably. Case reports, personal anecdotal experience, and small single-center case series are now recognized as having severe limitations to validity and have no role in formulating modern standards of practice. The major tools used to develop reliable evidence consist of the randomized clinical trial and the large observational registry.
An association between exposure to vehicular traffic in urban areas and the exacerbation
of cardiovascular disease has been suggested in previous studies. This study was
designed to assess whether exposure to traffic can trigger myocardial infarction.
We conducted a case–crossover study in which cases of myocardial infarction were
identified with the use of data from the Cooperative Health Research in the Region of
Augsburg Myocardial Infarction Registry in Augsburg, in southern Germany, for the
period from February 1999 to July 2001....
Several studies have compared outcomes for coronary-artery bypass grafting (CABG)
and percutaneous coronary intervention (PCI), but most were done before the availability
of stenting, which has revolutionized the latter approach.
We used New York’s cardiac registries to identify 37,212 patients with multivessel disease
who underwent CABG and 22,102 patients with multivessel disease who underwent
PCI from January 1, 1997, to December 31, 2000.
As mentioned in Appendix 2.2, it is recommended that cancer registries
use the International Classification of Diseases for Oncology (ICD-O) (Percy et
al., 1990) to code the topography (site of primary tumour) and morphol-
ogy (histological type) of the tumours. The fifth digit in the ICD-O mor-
phology codes describes the behaviour of the tumour—benign, borderline,
in situ, malignant. The topography of a tumour is the most important data
item recorded and provides the main basis of tabulation of registry data....