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  • Non-alcoholic fatty liver disease (NAFLD), like hepatitis C and HIV, is a disease of our generation. Mostly unrecognized prior to 1980 and seldom taken seriously until the past few years, NAFLD has seemingly been thrust upon us unexpectantly like an orphaned child left at our clinical bedside. In fact, NAFLD was conceived during the industrial revolution, which caused food to be processed differently, provided that food more abundantly and made physical work less demanding.

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  • Harrison's Internal Medicine Chapter 29. Disorders of the Eye The Human Visual System The visual system provides a supremely efficient means for the rapid assimilation of information from the environment to aid in the guidance of behavior. The act of seeing begins with the capture of images focused by the cornea and lens upon a light-sensitive membrane in the back of the eye, called the retina. The retina is actually part of the brain, banished to the periphery to serve as a transducer for the conversion of patterns of light energy into neuronal signals.

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  • Harrison's Internal Medicine Chapter 106. Plasma Cell Disorders Plasma Cell Disorders: Introduction The plasma cell disorders are monoclonal neoplasms related to each other by virtue of their development from common progenitors in the B lymphocyte lineage. Multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis (Chap. 324), and the heavy chain diseases comprise this group and may be designated by a variety of synonyms such as monoclonal gammopathies, paraproteinemias, plasma cell dyscrasias, and dysproteinemias.

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  • As for the fi rst edition of this volume, the chapters comprise comprehensive discussions of the some of the major non-infectious disorders of fi nfi sh. It is the second volume of a threevolume series on fi sh diseases and disorders; Volume 1 deals with parasitic diseases and Volume 3 with microbial diseases. Reviews in the three volumes are written by leading international authorities who are actively working in the area or who have contributed greatly to our understanding of specifi c diseases or disorders....

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  • Benign breast disease comprises a wide range of conditions which worry patients, which vex physicians, which are vastly more common than breast cancer, and yet which have to date received relatively little attention in the medical literature. It is therefore a particular pleasure for me to introduce the third edition of Hughes, Mansel & Webster’s Benign Disorders and Diseases of the Breast, a unique and classic work which fully succeeds in addressing this imbalance and builds on the substantial and well-deserved success of the first (1989) and second (2000) editions.

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  • Harrison's Internal Medicine Chapter 99. Disorders of Hemoglobin Disorders of Hemoglobin: Introduction Hemoglobin is critical for normal oxygen delivery to tissues; it is also present in erythrocytes in such high concentrations that it can alter red cell shape, deformability, and viscosity. Hemoglobinopathies are disorders affecting the structure, function, or production of hemoglobin. These conditions are usually inherited and range in severity from asymptomatic laboratory abnormalities to death in utero.

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  • In writing An Atlas of Parkinson’s Disease and Related Disorders, I have been conscious of the need to find an appropriate match between the text and the illustrative material. The text is designed to provide a basic overview of the conditions discussed, inevitably concentrating on those areas which lend themselves best to photographic illustration. Some movement disorders, by their very nature, do not lend themselves to still photography whereas others, characterized by sustained postures, are ideally suited to the technique.

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  • Tham khảo sách 'the gale encyclopedia of genetic disorders i', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • After a diabetes-related LEA has been reported to be as low as 28% to 31% (169, 170). Persons with renal failure or more proximal levels of amputation have a poor prognosis and higher mortality rate. Those who undergo a diabetesrelated amputation have a 40% to 50 % chance of undergoing a contralateral amputation within 2 years (36, 171, 172). ASSESSMENT OF THE DIABETIC FOOT (Pathway 1) The pedal manifestations of diabetes are well documented and potentially limb-threatening when left untreated.

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  • The Wiley Concise Guides to Mental Health are designed to provide mental health professionals with easily accessible overview of what is currently known about the nature and treatment of psychological disorders. Each book in the series delineates the origins, manifestations, and course of a commonly occurring disorder and discusses effective procedures for its treatment. The authors of the Concise Guides draw on relevant research as well as their clinical expertise to ground their text both in empirical findings and in wisdom gleaned from practical experience.

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  • A two-volume set designed for allied health students, patients, and the general public. The collection of alphabetically arranged entries covers rare and well-known neurological disorders, related medications and drug classes, patient and caregiver support, as well as background articles on the brain and nervous system anatomy"--

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  • Harrison's Internal Medicine Chapter 52. Approach to the Patient with a Skin Disorder APPROACH TO THE PATIENT WITH A SKIN DISORDER: INTRODUCTION The challenge of examining the skin lies in distinguishing normal from abnormal, significant findings from trivial ones, and in integrating pertinent signs and symptoms into an appropriate differential diagnosis. The fact that the largest organ in the body is visible is both an advantage and a disadvantage to those who examine it.

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  • A two-volume set designed for allied health students, patients, and the general public. The collection of alphabetically arranged entries covers rare and well-known neurological disorders, related medications and drug classes, patient and caregiver support, as well as background articles on the brain and nervous system anatomy"--

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  • Harrison's Internal Medicine Chapter 30. Disorders of Smell, Taste, and Hearing Smell The sense of smell determines the flavor and palatability of food and drink and serves, along with the trigeminal system, as a monitor of inhaled chemicals, including dangerous substances such as natural gas, smoke, and air pollutants. Olfactory dysfunction affects ~1% of people under age 60 and more than half of the population beyond this age. Definitions Smell is the perception of odor by the nose. Taste is the perception of salty, sweet, sour, or bitter by the tongue.

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  • Disorders of the Sense of Taste Disorders of the sense of taste are caused by conditions that interfere with the access of the tastant to the receptor cells in the taste bud (transport loss), injure receptor cells (sensory loss), or damage gustatory afferent nerves and central gustatory pathways (neural loss) (Table 30-2). Transport gustatory losses result from xerostomia due to many causes, including Sjögren's syndrome, radiation therapy, heavy-metal intoxication, and bacterial colonization of the taste pore.

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  • Figure 52-5 Meningococcemia. An example of fulminant meningococcemia with extensive angular purpuric patches. (Courtesy of Stephen E. Gellis, MD; with permission.) Figure 52-4 Necrotizing vasculitis. Palpable purpuric papules on the lower legs are seen in this patient with cutaneous small vessel vasculitis. (Courtesy of Robert Swerlick, MD; with permission.)[newpage] APPROACH TO THE PATIENT: SKIN DISORDER In examining the skin it is usually advisable to assess the patient before taking an extensive history.

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  • Dermatitis herpetiformis. This disorder typically displays pruritic, grouped papulovesicles on elbows, knees, buttocks, and posterior scalp. Vesicles are often excoriated due to associated pruritus. The shape of lesions is also an important feature. Flat, round, erythematous papules and plaques are common in many cutaneous diseases. However, targetshaped lesions that consist in part of erythematous plaques are specific for erythema multiforme (Fig. 52-9). In the same way, the arrangement of individual lesions is important.

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  • Harrison's Internal Medicine Chapter 61. Disorders of Granulocytes and Monocytes Disorders of Granulocytes and Monocytes: Introduction Leukocytes, the major cells comprising inflammatory and immune responses, include neutrophils, T and B lymphocytes, natural killer (NK) cells, monocytes, eosinophils, and basophils. These cells have specific functions, such as antibody production by B lymphocytes or destruction of bacteria by neutrophils, but in no single infectious disease is the exact role of the cell types completely established.

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  • Miscellaneous Metabolic disorders—ketoacidosis, acute renal failure, eclampsia, acute poisoning Drugs—lithium Other—metastatic carcinoma, acute hemorrhage or hemolysis Abnormal Neutrophil Function Inherited and acquired abnormalities of phagocyte function are listed in Table 61-3. The resulting diseases are best considered in terms of the functional defects of adherence, chemotaxis, and microbicidal activity. The distinguishing features of the important inherited disorders of phagocyte function are shown in Table 61-4.

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  • Representative patterns of serum electrophoresis. The upper panel illustrates the normal pattern of serum protein on electrophoresis. Since there are many different immunoglobulins in the serum, their differing mobilities in an electric field produce a broad peak. In conditions associated with increases in polyclonal immunoglobulin, the broad peak is more prominent (middle panel). In monoclonal gammopathies, the predominance of a product of a single cell produces a "church spire" sharp peak, usually in the γ globulin region (bottom panel).

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