Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data
The cause of macroglobulinemia is unknown. The disease is similar to myeloma in being slightly more common in men and occurring with increased incidence with age (median 64 years). There have been reports that the IgM in some patients with macroglobulinemia may have specificity for myelin-associated glycoprotein (MAG), a protein that has been associated with demyelinating disease of the peripheral nervous system and may be lost earlier and to a greater extent than the better known myelin basic protein in patients with multiple sclerosis.
Serum β2-microglobulin is a protein of 11,000 mol wt with homologies with the constant region of immunoglobulins that is the light chain of the class I major histocompatibility antigens (HLA-A, -B, -C) on the surface of every cell. Serum β2-microglobulin is the single most powerful predictor of survival and can substitute for staging. Patients with β2-microglobulin levels 0.004 g/L only 12 months. Serum β2-microglobulin and albumin levels are the basis for a three-stage International Staging System (ISS).
In many parts of the world the primary source of animal protein for humans is finfish. The
intensive culture of finfish has grown significantly since the 1980s partly because of the
dramatic decline in the natural fish stocks and the increase in fish consumption by the
ever-increasing population. For example, the worldwide consumption of fish between
1990 and 1997 increased by 30% while the capture fisheries increased only by 9%.
Representative patterns of serum electrophoresis. The upper panel illustrates the normal pattern of serum protein on electrophoresis. Since there are
many different immunoglobulins in the serum, their differing mobilities in an electric field produce a broad peak. In conditions associated with increases in polyclonal immunoglobulin, the broad peak is more prominent (middle panel). In monoclonal gammopathies, the predominance of a product of a single cell produces a "church spire" sharp peak, usually in the γ globulin region (bottom panel).
Protein phosphorylation is a reversible posttranslational modification catalyzed by
protein kinases and reversely by protein phosphatases. There are about 500 protein
kinases and 25-30 phosphatases in human genome. Each kinase and phosphatase
targets multiple substrates. Thus, protein phosphorylation is a most versatile signaling
regulatory mechanism and constitutes a most complicated signaling network in living
organisms. In fact, protein phosphorylation governs all aspects of physiological and
pathological processes in human health....
Chronic Granulomatous Disease Chronic granulomatous disease (CGD) is a group of disorders of granulocyte and monocyte oxidative metabolism. Although CGD is rare, with an incidence of 1 in 200,000 individuals, it is an important model of defective neutrophil oxidative metabolism. Most often CGD is inherited as an X-linked recessive trait; 30% of patients inherit the disease in an autosomal recessive pattern. Mutations in the genes for the four proteins that assemble at the plasma membrane account for all patients with CGD.
Hemolytic Uremic Syndrome HUS is a syndrome characterized by acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. It is seen predominantly in children and in most cases is preceded by an episode of diarrhea, often hemorrhagic in nature. Escherichia coli O157:H7 is the most frequent, although not only, etiologic serotype. HUS not associated with diarrhea (termed DHUS) is more heterogeneous in presentation and course.
von Willebrand Disease vWD is the most common inherited bleeding disorder. Estimates from laboratory data suggest a prevalence of approximately 1%, but data based on symptomatic individuals suggest that it is closer to 0.1% of the population. vWF serves two roles: (1) as the major adhesion molecule that tethers the platelet to the exposed subendothelium; and (2) as the binding protein for FVIII, resulting in significant prolongation of the FVIII half-life in circulation.
Coagulation Disorders Associated with Liver Failure The liver is central to hemostasis because it is the site of synthesis and clearance of most procoagulant and natural anticoagulant proteins and of essential components of the fibrinolytic system. Liver failure is associated with a high risk of bleeding due to deficient synthesis of procoagulant factors and enhanced fibrinolysis. Thrombocytopenia is common in patients with liver disease and may be due to congestive splenomegaly (hypersplenism), or immune-mediated shortened platelet life span (primary biliary cirrhosis).
Neurodegenerative disorders are common and devastating. Rationally, the most
effective treatments will target pathogenetic mechanisms. While alternative approaches,
based on alleviating the symptoms of patients with Alzheimer disease,
Parkinson disease, Huntington disease, prion disorders or amyotrophic lateral sclerosis,
can be expected to reduce suffering, studies of pathogenesis of these agerelated
disorderswill be most important for enabling early diagnosis and the creation
of preventative and curative treatments.
Intrinsically disordered proteins (IDPs) are functional proteins either fully
or partly lacking stable secondary and tertiary structure under physiologi-cal conditions that are involved in important biological functions, such as
regulation and signalling in eukaryotes, prokaryotes and viruses.
Protein aggregation can proceed via disordered or ordered mechanisms,
with the latter being associated with amyloid fibril formation, which has
been linked to a number of debilitating conditions including Alzheimer’s,
Parkinson’s and Creutzfeldt-Jakob diseases. Small heat-shock proteins
(sHsps), such as aB-crystallin, act as chaperones to prevent protein aggre-gation and are thought to play a key role in the prevention of protein-mis-folding diseases.
Advanced Topics in Biomineralization is a compendium of current topics focusing on processes of formation, organization, as well as mineralization of novel structural materials. From enchondral ossification to the application of biomineralized cement, the subject of biomineralization encompasses a range of diverse disciplines including molecular biology, supramolecular chemistry, materials science and engineering. A common theme in all these areas of research in biomineralization is the ability to utilize strategies from Nature to create functional materials.
Sepsis has been defined as a serious condition in which there is a systemic
inflammation secondary to an infectious process. This can progress to a level at which
it results in a complex disorder, leading to multiple organ failure and eventually
death. Although it has been well recognized as one of the top killers worldwide, its
incidence continues to rise dramatically with some studies showing approximately
1,400 daily deaths.
Some experts usually consider sepsis as one of the most challenging conditions
because of its multiple presentations and the variety of its complications. ...
Disease-Specific Nutritional Support
SNS is basically a support therapy and is primary therapy only for the treatment or prevention of malnutrition. Certain conditions require modification of nutritional support because of organ or system impairment. For instance, in nitrogen accumulation disorders, protein intake may need to be reduced. However, in renal disease, except for brief periods of several days, protein intakes should approach requirement levels of at least 0.8 g/kg or higher up to 1.2 g/kg as long as the blood urea nitrogen does not exceed 100 mg/dL.
Mối tương quan giữa chuyển hóa carbohydrate, chất béo và protein. In: các biên tập viên của Bondy PK, Rosenberg LE,. Kiểm soát và các bệnh chuyển hóa. Philadelphia: Saunders, năm 1980. 14. Brunzell JD, Bierman EL. Chylomicronemia hội chứng.