Disorders affecting

Xem 1-20 trên 123 kết quả Disorders affecting
  • Harrison's Internal Medicine Chapter 99. Disorders of Hemoglobin Disorders of Hemoglobin: Introduction Hemoglobin is critical for normal oxygen delivery to tissues; it is also present in erythrocytes in such high concentrations that it can alter red cell shape, deformability, and viscosity. Hemoglobinopathies are disorders affecting the structure, function, or production of hemoglobin. These conditions are usually inherited and range in severity from asymptomatic laboratory abnormalities to death in utero.

    pdf5p thanhongan 07-12-2010 48 8   Download

  • Incidence and Prevalence About 19,900 cases of myeloma were diagnosed in 2007, and 10,790 people died from the disease in the United States. Myeloma increases in incidence with age. The median age at diagnosis is 68 years; it is uncommon under age 40. The yearly incidence is around 4 per 100,000 and remarkably similar throughout the world. Males are more commonly affected than females, and blacks have nearly twice the incidence of whites. Myeloma accounts for ~1% of all malignancies in whites and 2% in blacks; 13% of all hematologic cancers in whites and 33% in blacks. The incidence of...

    pdf5p thanhongan 07-12-2010 34 8   Download

  • Heavy Chain Diseases The heavy chain diseases are rare lymphoplasmacytic malignancies. Their clinical manifestations vary with the heavy chain isotype. Patients secrete a defective heavy chain that usually has an intact Fc fragment and a deletion in the Fd region. Gamma, alpha, and mu heavy chain diseases have been described, but no reports of delta or epsilon heavy chain diseases have appeared. Molecular biologic analysis of these tumors has revealed structural genetic defects that may account for the aberrant chain secreted.

    pdf9p thanhongan 07-12-2010 44 7   Download

  • Bone pain is the most common symptom in myeloma, affecting nearly 70% of patients. The pain usually involves the back and ribs, and unlike the pain of metastatic carcinoma, which often is worse at night, the pain of myeloma is precipitated by movement. Persistent localized pain in a patient with myeloma usually signifies a pathologic fracture. The bone lesions of myeloma are caused by the proliferation of tumor cells, activation of osteoclasts that destroy bone, and suppression of osteoblasts that form new bone.

    pdf5p thanhongan 07-12-2010 27 6   Download

  • Harrison's Internal Medicine Chapter 30. Disorders of Smell, Taste, and Hearing Smell The sense of smell determines the flavor and palatability of food and drink and serves, along with the trigeminal system, as a monitor of inhaled chemicals, including dangerous substances such as natural gas, smoke, and air pollutants. Olfactory dysfunction affects ~1% of people under age 60 and more than half of the population beyond this age. Definitions Smell is the perception of odor by the nose. Taste is the perception of salty, sweet, sour, or bitter by the tongue.

    pdf6p ongxaemnumber1 29-11-2010 42 5   Download

  • Harrison's Internal Medicine Chapter 109. Disorders of Platelets and Vessel Wall Disorders of Platelets and Vessel Wall: Introduction Hemostasis is a dynamic process in which the platelet and the blood vessel wall play key roles. Platelets become activated upon adhesion to von Willebrand factor (vWF) and collagen in the exposed subendothelium after injury. Platelet activation is also mediated through shear forces imposed by blood flow itself, particularly in areas where the vessel wall is diseased, and is also affected by the inflammatory state of the endothelium.

    pdf5p thanhongan 07-12-2010 44 5   Download

  • Maternal Age and Trisomy The association between increasing maternal age and trisomy is the most important etiologic factor in congenital chromosomal disorders. Among women under the age of 25, ~2% of all clinically recognized pregnancies are trisomic; by the age of 36, however, this figure increases to 10% and by the age of 42, to 33% (Fig. 63-5). This association between maternal age and trisomy is exerted without respect to race, geography, or socioeconomic factors and likely affects segregation of all chromosomes.

    pdf5p konheokonmummim 03-12-2010 32 4   Download

  • Epidemiology Hemoglobinopathies are especially common in areas in which malaria is endemic. This clustering of hemoglobinopathies is assumed to reflect a selective survival advantage for the abnormal RBC, which presumably provide a less hospitable environment during the obligate RBC stages of the parasitic life cycle. Very young children with αthalassemia are more susceptible to infection with the nonlethal Plasmodium vivax. Thalassemia might then favor a natural protection against infection with the more lethal P. falciparum.

    pdf5p thanhongan 07-12-2010 36 4   Download

  • Unstable hemoglobins occur sporadically, often by spontaneous new mutations. Heterozygotes are often symptomatic because a significant Heinz body burden can develop even when the unstable variant accounts for a portion of the total hemoglobin. Symptomatic unstable hemoglobins tend to be β-globin variants, because sporadic mutations affecting only one of the four α-globins would generate only 20–30% abnormal hemoglobin. Hemoglobins with Altered Oxygen Affinity High-affinity hemoglobins [e.g.

    pdf5p thanhongan 07-12-2010 32 4   Download

  • Restless Legs Syndrome (RLS) Patients with this sensory-motor disorder report an irresistible urge to move the legs, or sometimes the upper extremities, that is often associated with a creepycrawling or aching dysesthesias deep within the affected limbs. For most patients with RLS, the dysesthesias and restlessness are much worse in the evening or night compared to the daytime and frequently interfere with the ability to fall asleep. The symptoms appear with inactivity and are temporarily relieved by movement.

    pdf5p ongxaemnumber1 29-11-2010 24 3   Download

  • Source: Modified from TA Roth, L Merlotti in SA Burton et al (eds), Narcolepsy 3rd International Symposium: Selected Symposium Proceedings, Chicago, Matrix Communications, 1989. Narcolepsy affects about 1 in 4000 people in the United States and appears to have a genetic basis.

    pdf4p ongxaemnumber1 29-11-2010 29 3   Download

  • Parasomnias The term parasomnia refers to abnormal behaviors or experiences that arise from or occur during sleep. A continuum of parasomnias arise from NREM sleep, from brief confusional arousals to sleepwalking and night terrors. The presenting complaint is usually related to the behavior itself, but the parasomnias can disturb sleep continuity or lead to mild impairments in daytime alertness. Two main parasomnias occur in REM sleep: REM sleep behavior disorder (RBD), which will be described below, and nightmare disorder.

    pdf5p ongxaemnumber1 29-11-2010 52 3   Download

  • Medical Implications of Circadian Rhythmicity Prominent circadian variations have been reported in the incidence of acute myocardial infarction, sudden cardiac death, and stroke, the leading causes of death in the United States. Platelet aggregability is increased after arising in the early morning hours, coincident with the peak incidence of these cardiovascular events. A better understanding of the possible role of circadian rhythmicity in the acute destabilization of a chronic condition such as atherosclerotic disease could improve the understanding of the pathophysiology.

    pdf8p ongxaemnumber1 29-11-2010 26 3   Download

  • Hemoglobin E HbE (i.e., α2β226Glu - Lys) is extremely common in Cambodia, Thailand, and Vietnam. The gene has become far more prevalent in the United States as a result of immigration of Asian persons, especially in California, where HbE is the most common variant detected. HbE is mildly unstable but not enough to affect RBC life span significantly. The high frequency of the HbE gene may be a result of the thalassemia phenotype associated with its inheritance. Heterozygotes resemble individuals with mild β-thalassemia trait.

    pdf5p thanhongan 07-12-2010 43 3   Download

  • Deletions involving the long arm of chromosome 22 (22q11) are the most common microdeletions identified to date, present in ~1/3000 newborns. VCF syndrome, the most commonly associated syndrome, consists of learning disabilities or mild mental retardation, palatal defects, a hypoplastic aloe nasi and long nose, and congenital heart defects (conotruncal defect).

    pdf7p konheokonmummim 03-12-2010 34 2   Download

  • Approach to the Patient: Thrombocytopenia The history and physical examination, results of the CBC, and review of the peripheral blood smear are all critical components in the initial evaluation of the thrombocytopenic patients (Fig. 109-2). The overall health of the patient and whether he/she is receiving drug treatment will influence the differential diagnosis. A healthy young adult with thrombocytopenia will have a much more limited differential diagnosis than an ill hospitalized patient who is receiving multiple medications.

    pdf5p thanhongan 07-12-2010 38 2   Download

  • Hemoglobin is critical for normal oxygen delivery to tissues; it is also present in erythrocytes in such high concentrations that it can alter red cell shape, deformability, and viscosity. Hemoglobinopathies are disorders affecting the structure, function, or production of hemoglobin. These conditions are usually inherited and range in severity from asymptomatic laboratory abnormalities to death in utero. Different forms may present as hemolytic anemia, erythrocytosis, cyanosis, or vasoocclusive stigmata. ...

    pdf24p socolanong 25-04-2012 26 2   Download

  • There are a wide range of problems that are considered psychological disorders, including mental and emotional disorders, problems related to alcohol and drug abuse, and some diseases that cause both emotional and physical symptoms. Psychological disorders often begin in early childhood, but during adolescence we see a sharp increase in the number of people affected by these disorders. It has been estimated that about 20 percent of the U.S. population will have some form of mental disorder sometime during their lifetime. Some psychological disorders appear following severe stress or trauma.

    pdf105p crius75 03-01-2013 14 2   Download

  • This is a concise description of the clinical manifestations frequently seen in the more common respiratory disorders affecting pediatric patients. After a brief description of each disease, the clinical findings associated with the disorder are summarized in table format. Students are cautioned that the tables represent a summary of the “classic” findings in moderately advanced cases. In reality the occurrence and degree of the typical findings vary with the severity of the disease and the patients overall health status.

    pdf6p nguyenhuucanh1212 23-01-2013 27 1   Download

  • Tham khảo tài liệu 'clinical, research and treatment approaches to affective disorders edited by mario francisco juruena', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

    pdf376p bachtuocpaul 15-04-2013 24 1   Download

CHỦ ĐỀ BẠN MUỐN TÌM

Đồng bộ tài khoản