A series of RNA-cleaving or DNA-cleaving DNAzymes have been
obtained by in vitro selection. However, engineering an allosteric
DNAzyme with dual RNA-cleaving and DNA-cleaving activities is very
challenging. We used an in vitro-selected pistol-like (PL) DNAzyme as a
DNA scaffold for designing a DNAzyme with dual catalytic activities.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites...
The urokinase-type plasminogen activator (uPA) receptor (uPAR) has been
implicated in signal transduction and biological processes including cancer
metastasis, angiogenesis, cell migration, and wound healing. It is a specific
cell surface receptor for its ligand uPA, which catalyzes the formation of
plasmin from plasminogen, thereby activating the proteolytic cascade that
contributes to the breakdown of extracellular matrix, a key step in cancer