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  • Toxicity The safe upper limit for vitamin B6 has been set at 100 mg/d, although no adverse effects have been associated with high intakes of vitamin B 6 from food sources only. When toxicity occurs, it causes a severe sensory neuropathy, leaving patients unable to walk. Some cases of photosensitivity and dermatitis have also been reported. Folate, Vitamin B12 See Chap. 90. Vitamin C Both ascorbic acid and its oxidized product dehydroascorbic acid are biologically active.

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  • Over the past few decades the field of neurology has seen spectacular developments in diagnostic techniques, most vividly exemplified by modern neuroimaging and molecular genetics. Although not always at the same speed this evolution has gone hand in hand with an enlarging armentarium of effective therapies to treat neurological disease.

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  • It is our pleasure to present the Proceedings of the 16th International Congress on Parkinson’s Disease (PD) and Related Disorders (16th ICPD) which took place in Berlin from June 5–9, 2005. This congress was the most successful congress ever with more than 3500 participants in the roaring German capital, consisting of an innovative program and with emphasis on bringing basic and clinical scientists together. Special attention has was paid in inviting young scientists.

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  • Psychiatric disturbance is common in both folate and cobalamin deficiencies. This, like the neuropathy, has been attributed to a failure of the synthesis of SAM, which is needed in methylation of biogenic amines (e.g., dopamine) as well as of proteins, phospholipids, and neurotransmitters in the brain (Fig. 100-1). Associations between lower serum folate or cobalamin levels and higher homocysteine levels and the development of Alzheimer's disease have been reported.

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