Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
Parkinson’s disease is characterized by preferential degeneration of the
dopamine-producing neurons of the brain stem substantia nigra. Imbal-ances between mechanisms governing dopamine transport across the
plasma membrane and cellular storage vesicles increase the level of toxic
pro-oxidative cytosolic dopamine.
Vào thời điểm bệnh Parkinson được chẩn đoán lâm sàng, là đã có sự mất các neuron hệ thống dopamine. Việc nhận biết những bệnh nhân giữa giai đoạn được cho là mất các neuron và sự xuất hiện triệu chứng có thể là yếu tố quan trọng đối với sự phát triển chiến lược điều trị bảo vệ thần kinh hiệu quả.
Chất chủ vận dopamine D3 giúp tái tạo thần kinh và phục hồi chức năng của não bệnh nhân Parkinson Bệnh Parkinson còn gọi là bệnh liệt rung, là một bệnh thoái hóa ở hệ thần kinh trung ương do sự mất các tế bào thần kinh sinh dopamine hay neuron sinh dopamine.
Caffeine, a nonselective adenosine A1 and A2A receptor antagonist, is the most widely used psychoactive substance in the world. Evidence demonstrates that caffeine and selective adenosine A2A antagonists interact with the neuronal systems involved in drug reinforcement, locomotor sensitization, and therapeutic effect in Parkinson's disease (PD). Evidence also indicates that low doses of caffeine and a selective adenosine A2A antagonist SCH58261 elicit locomotor stimulation whereas high doses of these drugs exert locomotor...
It is our pleasure to present the Proceedings of the 16th
International Congress on Parkinson’s Disease (PD) and
Related Disorders (16th ICPD) which took place in Berlin
from June 5–9, 2005. This congress was the most successful
congress ever with more than 3500 participants in the
roaring German capital, consisting of an innovative program
and with emphasis on bringing basic and clinical scientists
together. Special attention has was paid in inviting young
Parkinson’s disease (PD) is a heterogeneous movement disorder character-ized by progressive degeneration of dopamine neurons in substantia nigra.
We have previously presented genetic evidence for the possible involvement
of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying
genetic variants in ADH1C and ADH4 that associate with PD.
Parkinson’s disease (PD), a common progressive neurodegenerative disor-der, is characterized by degeneration of dopamine neurons in the substantia
nigra and neuronal proteinaceous aggregates called Lewy bodies (LBs).
The etiology of PD is probably a combination of environmental and
Fibrillization ofa-synuclein (a-Syn) is closely associated with the formation
of Lewy bodies in neurons and dopamine (DA) is a potent inhibitor for
the process, which is implicated in the causative pathogenesis of Parkin-son’s disease (PD). To elucidate any molecular mechanism that may have
biological relevance, we tested the inhibitory abilities of DA and several
analogs including chemically synthetic and natural polyphenols in vitro.
Phenothiazine drugs, including chlorpromazine and levomepromazine, have been being widely used as neuroleptics (major tranquilizers), antiparkinsonian drugs and antihistaminics for a long time . Table 1.1 shows chemical structures of representative phenothiazines. These drugs show blocking action on D2 receptors of dopaminergic neurons; there is close relationship between the receptor blocking and tranquilizing actions. The dopamine D2 receptor-blocking actions provoke extrapyramidal symptoms, such as muscular stiffness, tremor and ptyalism.
The neurons of the corpus striatum receive an excitatory input from the cerebral cortex and the thalamus.
The major outputs project to the globus pallidus and the substantia nigra pars reticula (SNr), and use
gamma-aminobutyric acid (GABA) as a transmitter. Major efferent pathways from the globus pallidus
interna and the SNr project to the thalamus. Feedback to the striatum is through the dopaminergic
striatonigral pathway originating in the substantia nigra pars compacta (SNc; Figure 1).
These separate pathways utilize different neuropeptides and dopamine receptors.