Xem 1-20 trên 53 kết quả Drug discovery
  • Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs.

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  • The discovery of efficacious new human therapeutic agents is one of humanity’s most vital tasks. It is an enormously demanding activity that requires creativity, a vast range of scientific knowledge, and great persistence. It is also an exceedingly expensive activity. In an ideal world, no education would be complete without some exposure to the ways in which new medicines are discovered and developed. For those young people interested in science or medicine, such knowledge is arguably mandatory....

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  • Great efficiencies have been achieved in the drug discovery process as a result of technological advances in target identification, high-throughput screening, high-throughput organic synthesis, just-in-time in vitro ADME (absorption, distribution, metabolism, and excretion), and early pharmacokinetic screening of drug leads. These advances, spanning target selection all the way through to clinical candidate selection, have placed greater and greater demands on the analytical community to develop robust high-throughput methods.

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  • The modern drug discovery process, in general, involves the identification of a biochemical target (usually protein target), screening of synthetic compounds or compound libraries from combinatorial chemistry/natural sources for a lead compound, and optimization of the lead compound (activity, selectivity, pharmacokinetics, etc.) for recommending a potential clinical candidate.

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  • Despite massive efforts in drug discovery fueled by combinatory chemistry, recombinant DNA technology, and highthroughput screening, surprisingly few molecules make it through the drug development process. While the reasons are debated, it is certain that many new chemical entities (NCEs) suffer from recurring problems that hinder development— low water solubility, instability, or inadequate pharmacokinetics. An estimated 43% of NCEs are poorly water-soluble.

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  • In a certain sense, the field of drug metabolism (DM) is standing still. More specifically, the basic experiment of drug metabolism (i.e., administering a new drug to an animal or human and determining the structures, amounts, and disposition of the metabolites) has changed very little over a period of decades. Remarkably, the experimental design and resulting data set from a typical absorption, distribution, metabolism, and excretion (ADME) study conducted today would be instantly recognized and understood by DM scientists from 50 years ago.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery...

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  • The workshop summarized in this volume was the third international meeting in a series sponsored by the Forum on Drug Discovery, Development, and Translation of the Institute of Medicine (IOM) to gather information from experts around the world on the threat of drugresistant tuberculosis (TB) and how it can be addressed. The workshop was held April 18-19 and 21, 2011, in New Delhi, India, in collaboration with the Indian National Science Academy (INSA) and the Indian Council of Medical Research (ICMR)....

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices...

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Digital drug discovery...

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  • Advanced Computer-Assisted Techniques in Drug Discovery edited by Han van de Waterbeemd .Methods and Principles in Medicinal Chemistry Edited by R. Mannhold P. Krogsgaard-Larsen H. Timmerman Volume 1 Hugo Kubinyi, QSAR: Hansch Analysis and Related Approaches Volume 2 Han van de Waterbeemd (ed.), Chemometric Methods in Molecular Design Volume 3 Han van de Waterbeemd (ed.), Advanced Computer- Assisted Techniques in Drug Discovery .Methods and Principles in Medicinal Chemistry edited by R. Mannhold, P. Krogsgaard-Larsen, H.

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  • It has been a privilege to watch the growth of RNA interference technology over the last ten years. Starting with a mixture of curiosity and chagrin, the field has grown into a substantial enterprise which impacts (and utilizes resources from) virtually every field of biomedical research. Research in RNAi derives from a set of apparently unconnected observations: strange pigment patterns in plants, unexpected failures and successes in antisense and overexpression studies, small regulatory RNAs in bacteria.

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  • It has been nearly 20 years since the last Humana Press book devoted to serotonin (5-hydroxytryptamine; 5-HT) receptors has appeared. Since then, the field of 5-HT receptors has undergone a revolution due to the discovery of many additional 5-HT receptors. Although 5-HT was chemically elucidated in 1948 by Page and colleagues (Rapport et al.

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  • Several years ago we noted a paucity of textbooks that dealt with the principles of pharmacology as a science rather than pharmacology as a therapeutic entity. In an attempt to remedy this we organized a textbook designed to meet the needs of students interested in pharmacology at the advanced undergraduate and early graduate level. This text addresses the many facets that form the foundation of pharmacology. Students will find extensive discussions by leaders in the field are written in clear and straightforward manner.

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  • For the last 60 or so years the chemotherapy of bacterial infections has been dominated by natural products and their semi-synthetic variants. Although the term antibiotic was initially used exclusively to describe those anti-bacterials of natural or semi-synthetic origin, it has become broadened in common usage to include antibacterial agents of purely synthetic origin as well. The emphasis of this chapter will be on the discovery of novel prototype structures that represent the different classes of antibiotic e.g.

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  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

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  • With publication of the human genome has come an experiment in reductionism for drug discovery. With the evaluation of the number and quality of new drug treatments from this approach has come a reevaluation of target-based versus systems-based strategies. Pharmacology, historically rooted in systems-based approaches and designed to give systems-independent measures of drug activity, is suitably poised to be a major (if not the major) tool in this new environment of drug discovery.

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  • (BQ) Part 1 book "Textbook of organic medicinal and pharmaceutical chemistry" presents the following contents: Drug design strategies, metabolic changes of drugs and related organic compounds, biotechnology and drug discovery, immunobiologicals, anti infective agents, antibacterial antibiotics, antiviral agents,...

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  • Medicinal chemistry is a discipline at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents (drugs). Compounds used in medical applications are most often organic compounds, which are often divided into the broad classes of small organic molecules and biologics, the latter of which are most often medicinal preparations of proteins. Inorganic and organometallic compounds are also useful as drugs.

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  • In the modern pharmaceutical industry, high-performance liquid chromatography (HPLC) is the major and integral analytical tool applied in all stages of drug discovery, development, and production. The development of new chemical entities (NCEs) is comprised of two major activities: drug discovery and drug development. The goal of the drug discovery program is to investigate a plethora of compounds employing fast screening approaches, leading to generation of lead compounds and then narrowing the selection through targeted synthesis and selective screening (lead optimization).

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