Drug dosage

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  • Drug Administration be very precise. (Standardized medicinal teaspoons and tablespoons are available.) Eye drops and nose drops (A) are designed for application to the mucosal surfaces of the eye (conjunctival sac) and nasal cavity, respectively. In order to prolong contact time, nasal drops are formulated as solutions of increased viscosity. Solid dosage forms include tablets, coated tablets, and capsules (B). Tablets have a disk-like shape, produced by mechanical compression of active substance, filler (e.g., lactose, calcium sulfate), binder, and auxiliary material (excipients).

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  • Pharmacology has undergone major intellectual changes in the recent years and has become increasingly important to all medical, dental and other health professionals. The graduate students of dentistry may have to handle medical emergency during various dental procedures on the dental chair. Besides this, dentists have to look into various drug associated interactions. The broad goal of teaching pharmacology to undergraduate students is to inculcate rational and scientific basis of therapeutics keeping in view the dental curriculum and profession.

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  • It has been over eight years since the first edition of the Handbook of Pharmaceutical Granulation Technology was published. The enthusiastic reception afforded by the scientific community was heartwarming. The basic science of granulation has not changed much over the last few years; however, a better understanding of the theory of granulation and the proliferation of different dosage forms has.

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  • This Handbook of Manufacturing Techniques focuses on a new aspect of the drug development challenge: producing and administering the physical drug products that we hope are going to provide valuable new pharmacotherapeutic tools in medicine. These 34 chapters cover the full range of approaches to developing and producing new formulations and new approaches to drug delivery. Also addressed are approaches to the issues of producing and packaging these drug products (that is, formulations).

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  • The subspecialty of population pharmacokinetics was introduced into clinical pharmacology / pharmacy in the late 1970s as a method for analyzing observational data collected during patient drug therapy in order to estimate patient-based pharmacokinetic parameters. It later became the basis for dosage individualization and rational pharmacotherapy. The population pharmacokinetics method (i.e., the population approach) was later extended to the characterization of the relationship between pharmacokinetics and pharmacodynamics, and into the discipline of pharmacometrics.

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  • This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of, translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product liability. The publisher can give no guarantee for all the information contained in this book. This also refers to that on drug dosage and application thereof. In each individual case the respective user

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  • Adjusting Drug Dosages While elimination half-life determines the time required to achieve steadystate plasma concentrations (Css), the magnitude of that steady state is determined by clearance (Cl) and dose alone.

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  • Renal Disease Renal excretion of parent drug and metabolites is generally accomplished by glomerular filtration and by specific drug transporters, only now being identified. If a drug or its metabolites are primarily excreted through the kidneys and increased drug levels are associated with adverse effects, drug dosages must be reduced in patients with renal dysfunction to avoid toxicity. The antiarrhythmics dofetilide and sotalol undergo predominant renal excretion and carry a risk of QT prolongation and arrhythmias if doses are not reduced in renal disease.

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  • Seven distinct antigenic botulinum toxins (BNT-A, -B, -C, -D, -E, -F, and -G) produced by different strains of Clostridium botulinum have been described. The human nervous system is susceptible to five toxin serotypes (BNT-A, -B, -E, -F, -G) and unaffected by 2 (BNT-C, -D). Although all toxins have different molecular targets, their action leads to the blockade of the cholinergic nerves. However, only the A and B toxins are available as drugs.

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  • What is the definition of a formulation? Why is it needed? What is the importance of a formulation? These are some important questions that need to be addressed during the development of a potential drug product. The strict definition of the word is to specify a formula or to express a formula in systematic terms or concepts. The formula, in the current case, is a pharmaceutical dosage form. A formulation is needed to deliver the drug or the active pharmaceutical ingredient (API) to its targeted site. In order to overcome some of the physiochemical limitations of an API,...

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  • The field of drug therapy is a rapidly changing and somewhat bewildering area to study. In developing and writing this textbook, we consulted the most up-to-date sources for information on new drug therapies. No textbook can be complete, especially when it covers an area as vast as the field of ocular pharmacology and therapeutics. Nonetheless, we have made a conscientious effort to cover the most important and commonly used medications in a format that is easy to read.

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  • Medicine is an everchanging science undergoing continual development. Research and clinical experience are continually expanding our knowledge, in particular our knowledge of proper treatment and drug therapy. Insofar as this book mentions any dosage or application, readers may rest assured that the authors, editors, and publishers have made every effort to ensure that such references are in accordance with the state of knowledge at the time of production of the book.

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  • Pharmacokinetics describes, in a quantitative manner, the passage of drugs through the body. A series of distinctive parameters such as bioavailability, volume of distribution and clearance are used to describe: --The rate and extent of drug absorption into the blood stream The rate and extent of drug movement out of blood into the tissues The rate of drug removal from the body These parameters can then be used to predict the blood concentration of drug that will arise with any given dosage regime. A diverse range of students will have some exposure to PKs....

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  • Adverse Reactions Adverse drug reactions are frequently classified by mechanism as either dose-related ("toxic") or unpredictable. Unpredictable reactions are either idiosyncratic or allergic. Dose-related reactions include aminoglycoside-induced nephrotoxicity, linezolid-induced thrombocytopenia, penicillin-induced seizures, and vancomycin-induced anaphylactoid reactions. Many of these reactions can be avoided by reducing dosage in patients with impaired renal function, limiting the duration of therapy, or reducing the rate of administration.

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  • Table 15-5 Treatment of Acute Migraine Drug Trade Name Dosage Simple Analgesics Acetaminophen, caffeine aspirin, Excedrin Migraine Two tablets or caplets q6h (max 8 per day) NSAIDs Naproxen Aleve, Anaprox, generic 220–550 mg PO bid Ibuprofen Advil, Motrin, Nuprin, generic 400 mg PO q3–4h Tolfenamic acid Clotam Rapid 200 mg PO.

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  • Inpatient Therapy Pneumococcal pneumonia is readily treatable with β-lactam antibiotics. The conventional dosages shown in Table 128-5 are acceptable against intermediately resistant strains and against many or most fully resistant isolates. Recommended agents include ceftriaxone and cefotaxime. Ampicillin is also widely used, usually in the form of ampicillin/sulbactam. The likely efficacy of newer quinolones such as moxifloxacin, macrolides such as azithromycin, and clindamycin is discussed above.

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  • Also, you may have read reports about the need to modify prescription dosing for people of different ages or ethnic groups. In fact, the physi- ology of aging greatly affects how medicines work in our bodies. This is worth talking about with your doctor or medical professional. Make any prescription dosage or schedule changes only with your doctor or medical professional, not on your own. The more medicines we take, the more we might experience drug-drug interactions. Many older people take eight different prescription and over-the-counter medicines.

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  • Tham khảo sách 'botulinum toxin in aesthetic medicine_2', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • L-3,4-Dihydroxyphenylalanine (L-dopa) remains the most effective phar-macological treatment for relief of the severe motor impairments of Par-kinson’s disease. It is very effective in controlling parkinsonian symptoms in the initial phase of the disease, but its action wanes with time. Such ‘wearing-off’ imposes an escalation in the dosage of the drug, which ulti-mately fails to provide stable control of motor symptoms and results in the appearance of abnormal involuntary movements or dyskinesia....

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