Public opinion on the medical value of marijuana has been
sharply divided. Some dismiss medical marijuana as a
hoax that exploits our natural compassion for the sick; others
claim it is a uniquely soothing medicine that has been
withheld from patients through regulations based on false
claims. Proponents of both views cite “scientific evidence”
to support their views and have expressed those views at
the ballot box in recent state elections.
In this book, the term Zen is used to roll together all of these con-
cepts. This is not an orthodox treatment of Zen. The book could have
been called the Yoga, Tao, or Way of Managing Projects. In the end all
of these terms are pointing to the same basic strategy—regard every-
thing as a part of a holistic, integrated system, set your intention to
include all of your personal and nonpersonal goals, apply objectivity
and subjectivity in dynamic balance, seek to perfect yourself and your
performance while not being hung up about your imperfections, and
recognize that a...
The marketing of agricultural commodities in the United States is done by a private enterprise
system. It involves millions of individual decisions (to grow, to buy, to sell, to store, to ship) on
the part of farmers, marketing men, and consumers.
Agricultural marketing is a huge national and international operation. The marketing system is
intricate. It is sensitive to many economic and international developments, which include
strikes, weather, political upheavals and related factors that affect marketing activities.
This balanced relationship is the basis of the underlying hypothesis of work undertaken by
Arts Access International (www.artsaccessinternational.org). The hypothesis states that: “the
way, from within ourselves, we look outwards at the world around us influences our perception of
factors in the external environment that impinge on us and how we respond to them. The relationship
is dynamic and symbiotic”.
This is the third volume in the series “Tutorial in Mathematical Biosciences”.
These lectures are based on material which was presented in tutorials or developed
by visitors and postdoctoral fellows of the Mathematical Biosciences
Institute (MBI), at The Ohio State University. The aim of this series is to introduce
graduate students and researchers with just a little background in either
mathematics or biology to mathematical modeling of biological processes.
The first volume was devoted to mathematical neuroscience, which was the
focus of the MBI program in 2002–2003.
Socio-Ecological Landscape Units (SELU) are
produced in turn from LCFU and other geographical
dimensions such as relief, belonging to a river basin,
or proximity to the sea. LCFU are agglomerated with
a methodology which maps dominant land‑cover
types. Large forests or agricultural areas will
constitute a SELU in their own right while smaller
units will be part of a larger zone characterised by
its dominant land cover. The Dominant Land Cover
Types are then classified according to river basins
and relief classes (e.g. coastal, lowland, highland,
We find that dynamically consistent (exponential) impatience cannot explain the
magnitude of the decline. The model needs either an implausibly large degree of annual
impatience, or a very large intertemporal elasticity of substitution. Intuitively, the
problem arises because the exponential discount rate is constant over time:1 even a mild
degree of short-run discounting, say a daily discount rate of 1 percent, implies a daily
discount factor of 0.99 and thus an annual discount factor of 0.99365 = 0.03.
Peer-to-peer systems and applications are distributed systems
without any centralized control or hierarchical organization, in
which each node runs software with equivalent functionality.
A review of the features of recent peer-to-peer applications
yields a long list: redundant storage, permanence, selection of
nearby servers, anonymity, search, authentication, and hierarchical
naming. Despite this rich set of features, the core operation
in most peer-to-peer systems is efficient location of data
The Internet has become an important form of communication in modern society, with a forecast
of 500 million online globally by the year 2003. 1 Its increased use and accessibility have led to a
burgeoning of cyber communities, where people of like minds and common interests transcend
geographical barriers and communicate with one another on a range of subjects, some trivial,
some controversial, and some intensely private.
Health care workers should explain the importance of directly observed treatment
as a standard of care for all patients. The health worker must watch the patient
swallow all the drugs. This will ensure that the patient takes the correct drugs
regularly for the required time. If injections are needed, they will be given
For example, if the patient does not take all of the drugs, he or she will continue to
spread TB to others, and his or her TB will not be cured. It is dangerous to stop or
interrupt treatment, because then...
Steroid hormone receptors are important drug targets and have been
the focus of basic and applied research for decades. Steroid hormone
receptors act as ligand-dependent transcription factors. Upon ligand
binding, the receptors bind to hormone responsive cis-acting DNA elements
(HREs) in the nucleus and regulate the expression of target genes
by recruiting chromatin-modifying activities that either promote or deny
access to the basal transcription machinery.
Enolase is a validated drug target inTrypanosoma brucei. To better charac-terize its properties and guide drug design efforts, we have determined six
new crystal structures of the enzyme, in various ligation states and confor-mations, and have carried out complementary molecular dynamics simula-tions.
We consider the problem of optimal investment in a risky asset, and in
derivatives written on the price process of this asset, when the underlying asset
price process is a pure jump L´ evy process. The duality approach of Karatzas
and Shreve is used to derive the optimal consumption and investment plans. In
our economy, the optimal derivative payoff can be constructed from dynamic
trading in the risky asset and in European options of all strikes.
Penicilliumantifungal protein (PAF) is a promising antimycotic without
toxic effects on mammalian cells and therefore may represent a drug candi-date against the often lethalAspergillusinfections that occur in humans.
The pathogenesis of PAF on sensitive fungi involves G-protein coupled sig-nalling followed by apoptosis.
Some of the poorest countries have significantly reduced
maternal and newborn mortality and improved women’s and
children’s health. Innovative approaches can achieve even more,
eliminating barriers to health and producing better outcomes.
These approaches need to be applied to all activities:
leadership, financing (including incentives to achieve better
performance and results), tools and interventions, service
delivery, monitoring and evaluation.
The most important trend in biological engineering is the dynamic range of scales at
which biotechnology is now able to integrate with biological processes. An explosion
in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug
delivery into cells, miniaturized implantable microsensors for medical diagnostics, and
micro-engineered robots for on-board tissue repairs. This book aims to provide an upto-
date overview of the recent developments in biological engineering from diverse
aspects and various applications in clinical and experimental research....
MODELLING AIDS EPIDEMIC AND TREATMENT WITH DIFFERENCE EQUATIONS
K. M. TAMIZHMANI, A. RAMANI, B. GRAMMATICOS, AND A. S. CARSTEA Received 15 October 2003 and in revised form 10 March 2004
We propose two models for the description of the dynamics of an AIDS epidemic and of the eﬀect of a combined-drugs AIDS treatment based on diﬀerence equations. We show that our interacting population model, despite its extreme simplicity, describes adequately the evolution of an AIDS epidemic. A cellular-automaton analogue of the discrete system of equations is presented as well.
Carbon-based nanoparticles and nanostructures, such as carbon nanotubes (CNTs), have
drawn great attention in both academia and industry due to their wide potential applica‐
tions. Owing to their well-defined one-dimensional (1D) interior, CNTs serve as desirable
materials for encapsulating molecules, such as water [1-4], ionic liquid , drug molecules
, and biomolecules .
This book does not provide a comprehensive overview of Multiple Myeloma but a collection of chapters with in-depth information of distinct hot topics in the diagnostic, research and therapeutic fields. The dynamics of testing new drugs for multiple myeloma treatment in clinical trials is breathtaking. Scientific discoveries have uncovered complicated pathogenesis of multiple myeloma; complicated reactions to treatment lead to the creation of super cocktails. Curability of multiple myeloma is a question that is being discussed by the entire professional myeloma world.