Drug release

Xem 1-20 trên 49 kết quả Drug release
  • For over 50 years, interest has been expressed in optimizing drug therapy through delivery system design. For many years this revolved around incorporating drugs into erodible or inert polymers, which then acted as platforms for controlled release, an approach that has been well reviewed in the literature.

    pdf962p thuytienvang_1 31-10-2012 32 1   Download

  • Products of nanotechnology are expected to revolutionize modern medicine, as evidenced by recent scientific advances and global initiatives to support nanotechnology and nanomedicine research. The field of drug delivery is a direct beneficiary of these advancements. Due to their versatility in targeting tissues, accessing deep molecular targets, and controlling drug release, nanoparticles are helping address challenges to face the delivery of modern, as well as conventional drugs.

    pdf427p thuytienvang_1 31-10-2012 16 1   Download

  • Drugs for the Suppression of Pain (Analgesics) ing, or burning character, i.e., pain that can be localized only poorly. Impulse traffic in the neo- and paleospinothalamic pathways is subject to modulation by descending projections that originate from the reticular formation and terminate at second-order neurons, at their synapses with first-order neurons, or at spinal segmental interneurons (descending antinociceptive system).

    pdf10p bigbaby87 04-09-2010 57 14   Download

  • Drugs Acting on Motor Systems spinal disorders. Benzodiazepines enhance the effectiveness of the inhibitory transmitter GABA (p. 226) at GABAA receptors. Baclofen stimulates GABAB receptors. !2-Adrenoceptor agonists such as clonidine and tizanidine probably act presynaptically to inhibit release of excitatory amino acid transmitters. The convulsant toxins, tetanus toxin (cause of wound tetanus) and strychnine diminish the efficacy of interneuronal synaptic inhibition mediated by the amino acid glycine (A).

    pdf12p bigbaby87 04-09-2010 61 9   Download

  • Introduction: Many of antidepressants exert their effects by inhibiting the reuptake of norepinephrine and serotonin and by accerelating the release of them at synaptic terminals of neurons in the brain. As characteristic structures of such drugs showing antidepressive effects, many of them have tricyclic or tetracyclic nuclei; this is the reason why they are called “tricyclic antidepressants or tetracyclic antidepressants”. There are many cases of suicides using the antidepressants; their massive intake sometimes causes death.

    pdf11p bigbaby87 01-09-2010 57 6   Download

  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

    pdf0p echbuon 02-11-2012 24 2   Download

  • In recent years, many researches have been developing towards biocompatible improvement and cellular penetrating ability of dendrimers in order to use in diagnosis and treatment therapy for several type of cancer. In this study, to enhance biocompatibility, drug loading efficiency and cellular uptake of the polyamidoamine dendrimer, the dendrimer generation 3.0 (G 3.0) was conjugated with hexanoyl chloride and targeted with acid folic (G3.0-C6-FA).

    pdf7p tangtuy01 01-03-2016 6 1   Download

  • Porous metal organic framework nanoscale carriers as a potential platform for drug delivery and imaging, In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading and or rapid release of the proportion of the drug that is simply adsorbed at the external surface of the nanocarrier.

    pdf7p hotrotaitailieu 30-03-2016 11 1   Download

  • This handbook emphasizes the use of synthetic membranes for separations involving industrial or municipal process streams. Little will be said concerning the use of membranes in medical applications as in artificial kidneys or for controlled drug release. Most of the membrane processes are pressure driven. The notable exception to this is electrodialysis (ED) by which ions are separated under the influence of an electric field. In addition, the chapter on coupled transport covers processes which are driven under the influence of a concentration gradient....

    pdf619p gian_anh 18-10-2012 66 24   Download

  • Over 98 per cent of sprayed insecticides and 95 per cent of herbicides reach a destination other than their target species, including non-target species, air, water and soil. Pesticide drift occurs when pesticides suspended in the air as particles are carried by wind to other areas, potentially contaminating them. Pesticides are one of the causes of water pollution and some pesticides are persistent organic pollutants and contribute to soil contamination. Detection of pesticide molecules in the food items from plant and animal origin become imperative for safe consumption of food.

    pdf236p conquynho32 18-09-2012 38 18   Download

  • Anyone who administers drugs acting on cardiovascular adrenergic mechanisms requires an understanding of how they act in order to use them to the best advantage and with safety. Adrenergic mechanisms Classification of sympathomimetics: by mode of action and selectivity for adrenoceptors Individual sympathomimetics Mucosal decongestants Shock Chronic orthostatic hypotension Adrenaline, noradrenaline and dopamine are formed in the body and are used in therapeutics. The natural synthetic path is: tyrosine — dopa — dopamine — noradrenaline — adrenaline.

    pdf13p bigbaby87 03-09-2010 49 8   Download

  • The theory of neurohumoral transmission received direct experimental validation nearly a century ago (see von Euler , 1981 ), and extensive investigation during the ensuing years led to its general acceptance. Nerves transmit information across most synapses and neuroeffector junctions by means of specific chemical agents known as neurohumoral transmitters or, more simply, neurotransmitters.

    doc230p vanass 01-04-2011 76 8   Download

  • This chapter describes the physiological role and pathophysical consequences of histamine release and provides a summary of the therapeutic use of histamine H1-receptor antagonists. H2-receptor antagonists are discussed in detail in Chapter 37: Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease in the context of prevention and treatment of peptic ulcers, their principal therapeutic application.

    doc154p vanass 01-04-2011 51 8   Download

  • The view of investor as customer also receives some weight from the fact that investors can redeem their mutual fund shares at net asset value at any time. This feature makes investing in a mutual fund unlike owning stock in a traditional company or a closed-end investment company, where the price at which an investor can liquidate reflects the market’s perception of the firm’s management. In that case, when management is revealed to have taken a “bad” action, current investors are damaged because they can resell their shares only at a much lower price.

    pdf21p quaivatdo 18-11-2012 23 5   Download

  • Examples ranged from gory low-budget horror to the sexploitation films of Russ Meyer. Elements of independent ‘exploitation’ strategy were also embraced by Hollywood in its more mainstream, blockbuster productions, especially the strategy of combining wide opening release patterns with saturation advertising, in order to recoup costs quickly. A number of Hollywood’s biggest-grossing films of the 1970s were, in part, bigger-budget and glossier versions of independent exploitation fare, especially The Exorcist (1973) and Jaws (1975)....

    pdf222p khanhchilam 01-04-2013 30 6   Download

  • A United Nations report says almost three million people in developing countries are now receiving drugs for H.I.V. This is an increase of almost one million people from two thousand six. Still, the hope was to reach three million by two thousand five. The World Health Organization, UNAIDS and UNICEF, the United Nations Children’s Fund, released the new report Tuesday.

    doc1p thuhangcdytbl 18-06-2011 27 4   Download

  • Biodegradable Systems 177 Figure 3 Cumulative release GCV from the scleral plugs of PLA-70,000 and PLA-5000 (whose content ratio was 80:20) containing 25% of GCV. The values shown are mean Æ SD. The duration of GCV release was prolonged further compared with the plug made of PLGA (75/25)-121,000. Abbreviations: GCV, ganciclovir; PLA, polylactic acid; PLGA, polyglycolic acid. Source: From Ref. 4. weight: 5000) at weight ratios of 80/20. These plugs included 25% GCV.

    pdf0p taoxanh8 16-11-2011 34 4   Download

  • Despite the advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects, and can harm normal cells and organs as well as diseased cells. Hence controlled release and the targeting of delivery systems must evolve in parallel to drug research.

    pdf174p thienbinh1311 13-12-2012 28 4   Download

  • The governor’s office has expressed the view that, since Planned Parenthood affiliates constitute just 2% of WHP providers, patients would have little difficulty finding alternative providers. Our analysis indicates that in the markets they serve, Planned Parenthood affiliates serve half, and sometimes much more than half, of all WHP patients.

    pdf8p connicquy 20-12-2012 17 4   Download

  • The dromedary’s water intake is through drinking and the water in the feed. The need for drinking depends on environmental temperature and humidity and the water content of the feed. Under range conditions if water is readily available, camels may drink daily or may not for several days. The main water losses are from evaporative cooling of the skin, in urine and faeces, and even in these functions the conservation of water can be very efficient. During exercise physiology studies, obvious sweating was not observed.

    pdf16p conduongdinhmenh 07-05-2013 12 4   Download

CHỦ ĐỀ BẠN MUỐN TÌM

Đồng bộ tài khoản