Drugs Acting on Motor Systems
spinal disorders. Benzodiazepines enhance the effectiveness of the inhibitory transmitter GABA (p. 226) at GABAA receptors. Baclofen stimulates GABAB receptors. !2-Adrenoceptor agonists such as clonidine and tizanidine probably act presynaptically to inhibit release of excitatory amino acid transmitters. The convulsant toxins, tetanus toxin (cause of wound tetanus) and strychnine diminish the efficacy of interneuronal synaptic inhibition mediated by the amino acid glycine (A).
Acute haematogenous osteomyelitis refers to infection of bone resulting from bacteria in the
bloodstream. This is seen most often in children, with initial infection thought to occur in the
richly vascularised metaphyseal region (Gutierrez, 2005). Children are thought to experience
frequent episodes of bacteraemia, often with no apparent symptoms, leading to seeding and
development of osteomyelitis (Conrad, 2010). The pathogenesis of this process has been
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