The beginning student in Organic Chemistry is often overwhelmed by facts, concepts, and new language.
Each year, textbooks of Organic Chemistry grow in quantity of subject matter and in level of sophistication.
This Schaum’s Outline was undertaken to give a clear view of first-year Organic Chemistry through the careful
detailed solution of illustrative problems. Such problems make up over 80% of the book, the remainder being a
concise presentation of the material. Our goal is for students to learn by thinking and solving problems rather
than by merely being told....
The pharmacy profession and the role of pharmacists in the modern healthcare systems have evolved quite rapidly over the last couple of decades. The services that pharmacists provide are expanding with the introduction of supplementary prescribing, provision of health checks, patient counselling and many others. The main ethos of pharmacy profession is now as much about keeping people healthy as treating them when they are not well.
After attending lectures, reading the text and working assigned problems related to this chapter, students will have acquired the following knowledge and abilities: Given the IUPAC name for a compound containing an amine functional group, be able to draw its structure; know the orbital mechanism for inversion at a pyramidal amine nitrogen; know how the relative electronegativity of N vs. O affects the boiling point, solubility, and basicity of amines vs. alcohols;...
Among halogens, fluorine is quite characteristic and specific since it has the
largest electronegativity (4.0 vs 3.5 for oxygen) and the sterically second smallest
van der Waals' radius (1.35 ~ vs. 1.20/~ for hydrogen). A carbon-fluorine bond
is also stronger than a carbon-hydrogen bond (485 kJ/mol vs 414 kJ/mol).
Therefore, fluoro organic compounds have unique chemical and physical
Chapter 1 introduction and review the organic chemistry. The goal is for you to learn: Review concepts from general chemistry that are essen-tial for success in organic chemistry, such as the electronic structure of the atom, Lewis structures and the octet rule, types of bonding, electronegativity, and formal charges; predict patterns of covalent and ionic bonding involving C, H, O, N, and the halogens. Identify resonancestabilized structures and compare the relative importance of their resonance forms.
Chemical reactions take place due to the redistribution of electron density among the
reacting partners. Focusing on changes in electron density, which accompany the
breaking and forming of chemical bonds, instead of the changes in the wave function
accompanying them, allows us to use the ‘‘classical’’ three-dimensional language.
Conceptual density functional theory (DFT) quantifies the possible responses of the
system to various changes in density.
In IONIC BONDING the valence electrons are completely
transferred from one atom to the other atom.
Ionic bonds occur between metals and nonmetals
when there is a large difference in electronegativity. In COVALENT BONDING the valence electrons are
shared as pairs between the bonded atoms.
Pure covalent bonding only occurs when two nonmetal
atoms of the same kind bind to each other. When two
different nonmetal atoms are bonded or a nonmetal and
a metal are bonded, then the bond is a mixture of covalent
and ionic bonding called polar covalent bonding.
The structure and dynamics of proteins and enzymatic activity
is intrinsically linked to the strength and positions of hydrogen
bonds in the system. A hydrogen bond results from an attractive
force between an electronegative atom and a hydrogen
atom. The hydrogen is attached to a strongly electronegative
heteroatom, such as oxygen or nitrogen, termed the hydrogen-
bond donor. This electronegative atom decentralizes
the electron cloud around the hydrogen nucleus, leaving the
hydrogen atom with a positive partial charge.