Retinoic acid and its relatives, natural products of vitamin A metabolism,
have been discovered to be critical ligands for key receptors of the steroid
receptor superfamily, such as the retinoic acid receptor and the RXR receptor.
Vitamins and Hormones has not had a review of this important fatsoluble
vitamin for some time, and it seemed important not only to touch on
the modern aspects of the retinoic acid receptor and its relatives but also of
the roles of vitamin A in development and diVerentiation as well as its
activity in certain tissues and in disease states....
MicroRNAs (miRNAs) are noncoding regulatory RNAs that function via
the degradation of target mRNAs and inhibition of translation. They are
found widely in higher eukaryotic organisms, and in several species that
have been closely examined, hundreds of miRNAs have thus far been
discovered with mechanistically conserved, yet functionally diverse, roles
necessary for the proper development, homeostasis and metabolism of
MicroRNAs (miRNAs) are involved in a plethora of important biological
processes, from embryonic development to homeostasis in adult tissues.
Recently, miRNAs have emerged as a class of epigenetic regulators of
metabolism and energy homeostasis.