Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption...
Understand the scientific basis of environmental endocrine disruption. • Explore the endocrine disruption hypothesis. • Review the classic case studies that have increased awareness in the public about environmental endocrine disruption. • Understand recent research and policy issues related to environmental endocrine disruption. • Explore the future pathways of analysis in the study of endocrine disruption.
The detection of pharmaceutical residues remained elusive until instruments such as liquid chromatography and mass spectrometry became commonplace in environmental laboratories. The documentation of the occurrence of pharmaceutical residues and endocrine disrupting chemicals in water resources has raused questions about their long-term effects in the ecosystem and their potential effects on human health.
Đề tài “Sử dụng và quản lý hóa chất công nghiệp có thể có tác dụng gây xáo trộn hệ thống nội tiết tố” đã được các nhà khoa học nêu lên từ lâu. Hiện nay, nhiều nước trên thế giới rất quan tâm đến các hóa chất được xếp vào loại gây rối loạn nội tiết tố EDC (Endocrine Disrupting Chemicals) có thể dẫn đến dị tật bẩm sinh của một số loài động vật, kể cả con người. Nhiều hội nghị quốc tế về EDC đã diễn ra tại các nước, kể cả Việt Nam.
in Fishes and Invertebrates: Issues for Saltwater Ecological Risk Assessment - Chương này xem xét một số vấn đề liên quan đến đánh giá rủi ro của nội tiết
gây ảnh hưởng hóa chất (EDCs) trong môi trường nước mặn.
For many years, interest in the prevention of diseases in children was concentrated
on improvement of the postnatal environment. However, since the major problems
of infectious diseases and nutrition were solved with the help of vaccinations and
better feeding regimes, it became clear that new approaches were needed to prevent
and treat the disorders and problems we are facing now - problems mainly arising in
The scope of environmental impact on reproduction is very large. It aims at covering
all aspects of reproductive problems and their links to the environment. Therefore,
it deals with female and male reproductive impairments, whatever their severity and
their sites, gonad or extra-gonad.
Over the past 2 decades the implications of endocrine disruption and modula-
tion have permeated public consciousness, scienti fi c inquiry, regulatory frame-
works, and management decisions in the environmental and biomedical sciences.
Hecker and Hollert Environmental Sciences Europe 2011, 23:15 http://www.enveurope.com/content/23/1/15
Endocrine disruptor screening: regulatory perspectives and needs
Markus Hecker1* and Henner Hollert2*
Abstract National and international governments are in the process of establishing testing programs and strategies to assess the safety of currently used chemicals with regard to their potential to interact with the endocrine system of man and wildlife, resulting in potential impacts on reproduction, growth, and/or development.
Since the synthesis of DDT during 1874 several insecticide molecules have been
identified and synthesized globally for the control of insect pests, pathogens, microbes,
vectors of human and animal diseases, weeds and other obnoxious organisms.
Currently, 1.8 billion kgs of pesticides are used annually worldwide in the form of
herbicides, insecticides and fungicides. There are more than 1055 active ingredients
registered as pesticides till date implying that there is no best alternate for the
During the last two decades, evidence of increasing trends of several endocrine-related disorders has been strengthened. These disorders often come with lack of uniform diagnosis and/ or even unclear endocrine disruption. The later is mainly due to abnormal classical changes in the blood- released hormone to its targeted organ, abnormal communication between cells within a tissue or organ (paracrine), within the same cell (intracrine) or signals which act on the same cell (autocrine).
This lab will introduce students to a simple bioassay that will allow them to explore the effects
that a chemical's concentration has on the level of toxicity. By relying on morphological
examination of sponges hatching from gemmules that are smaller than a millimeter in diameter, this
module will help students develop their microscopy skills. Our major aim, however, is to have
students strengthen their ability to design and test their own hypotheses.
Results from this laboratory can be used for a discussion of the biological consequences of
pollution and will provide students with an appreciation for how dilution influences a chemical's
biological effect. While endocrine disrupters are currently a 'hot topic,' other pollutants could also
be tested. We tested some heavy metals (which are a perennial concern) and had some very
interesting growth abnormalities show up. Chemical pollutants are not the only parameters that may
influence sponge growth.
This lab uses freshwater sponges as model organisms to examine the biological effects of
water pollution. Specifically, the focus of this laboratory module is on the effects that chemicals of
environmental concern (e.g., endocrine disrupters) have on sponge growth and development.
Contamination of aquatic ecosystems is a serious issue in environmental science. Identifying which
chemicals we should be concerned with, and determining the consequences of contamination by
specific compounds, is a major area of current research.
A robust body of literature details reproductive effects in fish,
amphibians, and reptiles related to exposure to endocrine
disruptors. Evidence of these effects has also been seen in wild
mammals such as polar bears and seals. Environmental exposure
assessments and wildlife, laboratory and epidemiologic studies
show exposure to low-level environmental contaminants, such
as pesticides and other chemicals, subtly undermines the ability
of children’s environmental health (CEH) issues is compounded by the
combination of legacy environmental issues, such as water quality and
sanitation service delivery, with modern challenges such as transboundary
contamination by persistent toxic substances, ozone depletion and hence
ultraviolet and ionising radiation, global climate change, and exposure to
Nearly a decade elapsed between publication of the second and third editions
of Basic Medical Endocrinology due in large part to the turmoil in the publishing
industry brought on by massive consolidation.Although this edition is new and the
publisher is new, the aims of earlier editions of this work are unchanged. Its focus
remains human endocrinology with an emphasis on cellular and molecular
mechanisms presented in the context of integration of body functions.
Synthetic chemicals known as endocrine disruptors are
an excellent example of emerging contaminants where the
threats and consequences for water quality, human health,
and the environment are still not fully understood. Endocrine
disruptors – chemicals that can interfere with hormone
action – have been identified among chemicals used in
agriculture, industry, and households, and for personal
care, including pesticides, disinfectants, plastic additives,
and pharmaceuticals like birth control pills.
Common household products –detergents, disinfectants, plastics, and pesticides– contain chemical ingredients that enter the body,
disrupt hormones and cause adverse developmental, disease, and reproductive problems. Known as endocrine disruptors, these
chemicals, which interact with the endocrine system, wreak havoc in humans and wildlife.