Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: a case report
At the beginning of the 21st century, medicine is increasingly
based on understanding the functions of genes and the molecular
mechanisms of diseases. In pancreatology, the understanding
of functions and dysfunctions of the exocrine and
endocrine pancreas is derived from molecular biological data
on the actions of compounds in subcellular compartments and
intracellular transcription pathways.
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and heterogeneous
neoplasms with overall increasing incidence, but not an associated increase in survival rate
over the past few decades. Tumors originate from at least 16 different cells of diffuse
endocrine system (DES), scattered through mucosa of gastrointestinal tract. They are mainly
sporadic, but sometimes exhibit familial inheritance.
Today, computed tomography (CT) is the most commonly
used imaging method in the assessment of pancreatic
tumors. The sensitivity of CT in detection of pancreatic
tumors is more than 90% when direct and indirect signs
are used for diagnosis. However, the potential to differentiate
exocrine (non-endocrine) tumors of the pancreas
is limited. CT is used in these lesions to perform an adequate
staging, especially for surgical purposes. The
operative resectability, primarily in regard to vessels,
lymph node metastasis and hepatic metastasis, has to be
It has been said that the control of disease has three goals, which, in
increasing order of attraction are palliation, cure, and prevention. For most types
of disseminated cancer, medical science has achieved only the first of these
objectives, while for some malignancies the side effects of the therapeutic agents
employed rival the disease itself in precluding a desirable quality of life.
It was noted before that several synthetic copper chemicals are used in organic agriculture as
fungicides. Although small amounts of copper are essential for life, it is a toxic element at higher
levels. There have been reports of people committing suicide by ingesting it. Vineyard sprayers have
experienced liver disease from exposure to it. It is corrosive to the skin and eyes and is absorbed
through the skin. It causes reproductive problems in birds, hamsters and rats. It has been shown to
induce heart disease in the offspring of pregnant hamsters that were exposed to it.
(BQ) Part 1 book "Gastrointestinal pathology and its clinical implications" presents the following contents: Dialogue, biopsies–taking and handling, resected specimens; protocols; vascular disorders and related diseases, immunodeficiency disorders, disorders of endocrine cells, motility disorders, mesenchymal tumors,...
(BQ) Part 2 book "Color atlas of oral diseases" presents the following contents: Autoimmune diseases, skin diseases, precancerous lesions, precancerous conditions, malignant neoplasms, endocrine diseases, diseases of the peripheral nervous, other salivary gland disorders, benign tumors,...
(BQ) Part 2 book "Clinical chemistry - Quality in laboratory diagnosis" presents the following contents: Endocrine/tumor markers/special chemistry; laboratory information systems/informatics, laboratory safety, outreach testing.
Accurate statistics on cancer occurrence and outcome are essential both for the purposes of
research and for planning and evaluation programmes for cancer control (Parkin, 2006).
Although tumours of thyroid account for only 1% of the overall human cancer burden, they
represent the most common malignancies of the endocrine system and pose a significant
challenge to pathologists, surgeons and endocrinologists. Among epithelial tumors,
carcinomas of follicular cell origin far outnumber those of C-cell origin.
While most autosomal dominant inherited cancer syndromes are due to mutations in tumor-suppressor genes (Table 79-1), there are a few interesting exceptions. Multiple endocrine neoplasia type II, a dominant disorder characterized by pituitary adenomas, medullary carcinoma of the thyroid, and (in some pedigrees) pheochromocytoma, is due to gain-of-function mutations in the protooncogene RET on chromosome 10. Similarly, gain-of-function mutations in the tyrosine kinase domain of the MET oncogene lead to hereditary papillary renal carcinoma.
Endocrine Therapy Normal breast tissue is estrogen-dependent. Both primary and metastatic breast cancer may retain this phenotype. The best means of ascertaining whether a breast cancer is hormone-dependent is through analysis of estrogen and progesterone receptor levels on the tumor. Tumors that are positive for the estrogen receptor and negative for the progesterone receptor have a response rate of ~30%. Tumors that have both receptors have a response rate approaching 70%. If neither receptor is present, the objective response rates are ...
Ectopic hormone production would only be an epiphenomenon associated with cancer if it did not result in clinical manifestations. Excessive and unregulated production of hormones such as ACTH, PTHrP, or vasopressin can lead to substantial morbidity and can complicate the cancer treatment plan. Moreover, the paraneoplastic endocrinopathies are sometimes the presenting feature of underlying malignancy and may prompt the search for an unrecognized tumor.
Hematologic Syndromes: Introduction The elevation of granulocyte, platelet, and eosinophil counts in most patients with myeloproliferative disorders is caused by the proliferation of the myeloid elements due to the underlying disease rather than a paraneoplastic syndrome. The paraneoplastic hematologic syndromes in patients with solid tumors are less well characterized than the endocrine syndromes because the ectopic hormone(s) or cytokines responsible have not been identified in most of these tumors (Table 96-2).
AT is recognized as the largest energy store of free fatty acids (FFA) and triglycerides (TG),
and more recently as an endocrine organ that regulates the secretion of adipokines, which
coordinate energy metabolism, insulin sensitivity and feeding behavior, not only in adults
but also in pediatric populations. Imbalance between visceral and subcutaneous AT is
capable of altering its physiology.