Enzymes are proteins that catalyze chemical reactions. A protein is simply a polypeptide
composed of amino acids linked by a peptide bond, and the term generally, but
not always, refers to the folded conformation. To understand how an enzyme functions,
including its binding and functional properties, it is necessary to know the
properties of the amino acids and how the amino acids are linked together, including
the torsion angles of the bonds and the space occupied, and the interactions of the
atoms leading to the final conformations of the folded protein.
The book is intended to provide a sound basis for enzyme reactor design based on kinetic principles, and give an updated vision of the potentials and limitations of enzyme biocatalysis, especially with respect to recent applications in processes of organic synthesis. The book is structured in the form of a textbook that goes from basic principles of enzyme structure and function to reactor design for homogeneous systems with soluble enzymes, and heterogeneous systems with insolubilized enzymes.
(BQ) Part 1 book "BRS Biochemistry, molecular biology and genetics" presents the following contents: Organic chemistry review; protein structure and function; enzymes, biochemistry of digestion; glycolysis; the tricarboxylic acid cycle, electron transport chain, and oxidative metabolism; glycogen metabolism; gluconeogenesis and the maintenance of blood glucose levels,... and other contents.
Living processes consists almost entirely of biochemical
reactions. Without catalysts these reactions would not occur fast
enough to sustain life.How does an enzyme
------ because enzyme
is a catalytic protein-a
chemical agent that
changes the rate of a
reaction without being
consumed by the
(BQ) Part 1 book "Textbook of biochemistry" presents the following contents: Biochemical perspective to medicine, amino acids structure and properties, proteins structure and function, enzymology general concepts and enzyme kinetics, chemistry of lipids,... Invite you to consult.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Influence of metabolic network structure and function on enzyme evolution...
(BQ) Part 1 book "Harper’s illustrated biochemistry" presents the following contents: Structures and functions of proteins and enzyme; bioenergetics and the metabolism of carbohydrates and lipids; metabolism of proteins and amino acids.
A novel plant protein isolated from the underground bulbs of
Scadoxus multiflorus, xylanase and a-amylase inhibitor protein (XAIP),
inhibits two structurally and functionally unrelated enzymes: xylanase and
a-amylase. The mature protein contains 272 amino acid residues which
show sequence identities of 48% to the plant chitinase hevamine and 36%
to xylanase inhibitor protein-I, a double-headed inhibitor of GH10 and
Bacterial l-asparaginases are enzymes that catalyze the hydrolysis of
l-asparagine to aspartic acid. For the past 30 years, these enzymes have
been used as therapeutic agents in the treatment of acute childhood
Cholesterol oxidase is a bacterial FAD-containing flavooxidase that catalyzes
the first reaction in cholesterol catabolism. Indeed, this enzyme catalyzes two
reactions: the oxidation of the C3
-OH group of cholesterol (and other sterols)
to give cholest-5-en-3-one; and its isomerization to cholest-4-en-3-one. In the
past several years, the structural and functional characterization of choles-terol oxidase has been developed together with its application as a biological
The structure of the Mg
-dependent enzyme human
phosphoserine phosphatase (HPSP) was exploited to
examine the structural and functional role of the divalent
cation in the active site of phosphatases. Most interesting is
the biochemical observation that a Ca
ion inhibits the
activity of HPSP, even in the presence of added Mg
sixfold coordinated Mg
ion present in the active site of
HPSP under normal physiological conditions, was replaced
by a Ca
ion by using a crystallization conditionwith high
concentration of CaCl2(0.7M). ...
Although belonging to the widely investigated peroxidase
superfamily, lactoperoxidase (LPO) and myeloperoxidase
(MPO) share structural and functional features that make
them peculiar with respect to other enzymes of the same
group. A survey of the available literature on their catalytic
intermediates enabled us to ask some questions that
remained unanswered. These questions concern controver-sial features of theLPOandMPOcatalytic cycle, suchas the
existence of Compound I and Compound II isomers and
the identification of their spectroscopic properties....
We have previously reported that two trypsin-like enzymes,
acrosin and spermosin, play key roles in sperm penetration
through the vitelline coat of the ascidian (Urochordata)
Halocynthia roretzi[Sawadaet al. (1984),J. Biol. Chem.259,
2900±2904; Sawadaet al. (1984), Dev. Biol.105, 246±249].
Here, we show the amino-acid sequence of the ascidian
preprospermosin, which is deduced from the nucleotide
sequence of the isolated cDNA clone.
We live in the age of biology—the human and many other organisms’
genomes have been sequenced and we are starting to understand the
function of the metabolic machinery responsible for life on our planet.
Thousands of new genes have been discovered, many of these coding for
enzymes of yet unknown function. Understanding the kinetic behavior
of an enzyme provides clues to its possible physiological role. From
a biotechnological point of view, knowledge of the catalytic properties
of an enzyme is required for the design of immobilized enzyme-based
LIFE ON EARTH ULTIMATELY DEPENDS ON ENERGY derived from the sun. Photosynthesis is the only process of biological importance that can harvest this energy. In addition, a large fraction of the planet’s energy resources results from photosynthetic activity in either recent or ancient times (fossil fuels). This chapter introduces the basic physical principles that underlie photosynthetic energy storage and the current understanding of the structure and function of the photosynthetic apparatus (Blankenship 2002). The term photosynthesis means literally “synthesis using light.
- Polysaccharides are macromolecules, polymers with a few hundred to a few thousand monosaccharides joined by glycosidic linkages.
- Some polysaccharides serve as storage material, hydrolyzed as needed to provide sugar for cells.
- Other polysaccharides serve as building material for structures that protect the cell or the whole organism.
- The architecture and function of a polysaccharide are determined by its sugar monomers and by the positions of its glycosidic linkages.
Metabolism ofD-amino acids is of considerable interest due to their key
importance in cell structure and function. Salmonella typhimuriumD-serine
deaminase (StDSD) is a pyridoxal 5¢ phosphate (PLP) dependent enzyme that
catalyses degradation of D-Ser to pyruvate and ammonia.
3-carboxy-cis,cis-muconate lactonizing enzymes participate in the protoca-techuate branch of the 3-oxoadipate pathway of various aerobic bacteria.
The gene encoding a 3-carboxy-cis,cis-muconate lactonizing enzyme
(pcaB1S2) was cloned from a gene cluster involved in protocatechuate deg-radation by Agrobacterium radiobacterstrain S2.
The bifunctional enzyme glucose-6-phosphate dehydrogenase-6-phospho-gluconolactonase (G6PD-6PGL) found in Plasmodium falciparum has
unique structural and functional characteristics restricted to this genus.
This study was designed to examine the effects of RNA-mediated PfG6PD-6PGL gene silencing in cultures ofP. falciparumon the expression of para-site antioxidant defense genes at the transcription level.