This book describes different perspectives of childhood acute lymphoblastic leukemia. The approach includes aspects of molecular epidemiology, particularly molecular features that influence the genesis and prognosis of the disease. Some aspects of the prognosis of lymphoblastic leukemias are very detailed, highlighting the use of molecular biology in the early identification of complications that may occur in diseased patients.
As the global epidemic of diabetes continues to expand, the prevalence of type 2 diabetes is predicted to double in
the next 20 years. Continued population growth, increasing age, and worldwide globalization leading to changes in
diet and patterns of physical inactivity have resulted in staggering numbers of individuals affected by the disease.
A haphazard approach to treatment for a problem of this magnitude could easily overburden the healthcare system,
particularly in areas of the world with limited resources.
Evidence-based dermatology is no longer a swear word in dermatology. Most dermatologists are
practising good evidence-based dermatology to different degrees. The challenge is to improve those
skills. This book may help you.
This book has a been labour of love for me, my associate editors and chapter contributors and I wish to
thank them all for their efforts.
The global environment is changing rapidly, partly in response to economic
globalization. These global changes are clearly evident at the local level, even in
the quality of air that people breath. In some high income countries air quality
has been improving, due to a combination of de-industrialization, improved
technologies and environmental regulation. However, advances in the science of
epidemiology suggest that even air that would until recently have been
considered ‘clean’ may contain pollutants that are hazardous to people’s health.
This book has been written to enable health care workers to understand the principles of
managing an acute medical emergency safely and effectively.To achieve this aim it provides
a structured approach to medical emergencies, describing relevant pathophysiology
that will also help to explain physical signs and the rationale behind treatment.The first
edition of this manual (written by Terry Wardle) has undergone significant modification
directed by the working group and also, in particular, candidates from the first
Thus, in living cells, the rates of anterograde and retrograde transport between the two
organelles appear to have a substantial effect on the morphology of the Golgi. The effect of
the balance between anterograde and retrograde transport on the morphology of the ER
remains to be explored. Recently, increasing evidence has suggested that alteration in Golgi
morphology during mitosis is not a passive process but rather an active one, which is highly
coordinated with entry into mitosis and its progression.
Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base.
The patient admitted to the hospital is already an individual who is at risk because
of an underlying pathology that requires inpatient care. When patients decline,
they have evidence of clinical deterioration (hypoxia, hypotension, tachypnoea,
tachycardia, altered level of consciousness) that is often documented in the medical
record 8 to 48 hours prior to a crisis being detected
Cardiovascular emergencies account for 30–40% of an acute
medical workload that has grown inexorably over the last two
decades. The same period has also witnessed unprecedented
changes in the classification, investigation and treatment of
acute cardiac problems, driven by advances in basic sciences,
pharmacology and technology, but above all by a proliferating
body of evidence from controlled trials.
The benefit-to-risk ratio of blood products needs constant
evaluation. Blood products, as therapeutic agents,
have had the test of time but lack the evidence we expect
from other medicinals. Blood, an organ, is used as
a pharmaceutical agent by the medical profession, due to
the achievements in collection, processing, banking, and
distribution. The fact that the most common risk of blood
transfusion isblood delivery error supports the notion that
blood is handled as a pharmaceutical agent.
Hemodynamic monitoring is one of the major diagnostic tools available in the
acute care setting to diagnose cardiovascular insufficiency and monitor changes
over time in response to interventions. However, in recent years, the rationale and
efficacy of hemodynamic monitoring to affect outcome has come into question.
We now have increasing evidence that outcome from critical illness can be improved
by focused resuscitation based on existing hemodynamic monitoring,
whereas non-specific aggressive resuscitation impairs survival.
There is growing evidence on the importance of studies focusing on mechanisms and
strategies leading to cancer prevention. The plethora of approaches include regulation
of oxidative stress using antioxidant therapies, carefully balanced diets and living
habits, epidemiological evidence and molecular approaches on the role of key
biological molecules such as antioxidant enzymes, vitamins, proteins and naturally
occurring free radical scavengers as well as controversial results and clinical
applications. These are some of the topics that this book highlights.
Differentiated thyroid cancer is the fastest‐growing cancer in women; it increased 2.4%
per year during 1980 to 1997 and 6.5% per year during 1997 to 2006 in the USA according
to the National Cancer Instituteʹs Surveillance Epidemiology and End Results (SEER).
On the other hand, the refinement of new approaches for surveillance of patients with an
established diagnosis of thyroid cancer is leading to the observation that many patients,
previously thought to be cured, have evidence of minimal residual disease, a condition
with which we still do not know how to manage properly....
Demographic and epidemiological transitions and changes in lifestyle are leading to the
emergence of cancer and other chronic diseases as public health problems in India. Cancer
pattern in India reveals the predominance of tobacco related cancers, which are amenable
to primary prevention. Cancer Registries in different parts of the country reveal that majority
of cancer cases present in an advanced stage and makes treatment options prolonged and
This study examines how different types of performance measures were
weighted in a subjective balanced scorecard bonus plan adopted by a major financial
services firm. Drawing upon economic and psychological studies on performance evaluation
and compensation criteria, we develop hypotheses regarding the weights placed
on different types of measures.
The series Essentials in Ophthalmology was initiated
two years ago to expedite the timely transfer
of new information in vision science and
evidence-based medicine into clinical practice.
We thought that this prospicient idea would be
moved and guided by a resolute commitment
to excellence. It is reasonable to now update our
readers with what has been achieved.
Increasing evidence suggests that serious mental illness is neurodevelopmental and the
onset of pre-psychotic symptoms occurs in adolescence, at a time when the cerebral cortex is
still developing. As with many complex disorders (e.g. hypertension, epilepsy, and
diabetes), there appear to be many aetiological pathways that might lead to the final mixture
of behavioral signs and symptoms we label ‘schizophrenia’.
Latex intolerance has become an increasingly important concept and diagnosis. In this
textbook, we have aimed to cover all aspects of latex allergy including contact urticaria,
irritation, and allergic contact dermatitis. An evidence-based and practical approach has
been taken to describe the epidemiology, basic science, clinical presentation,
management, and prognosis of the varied manifestations of natural rubber latex
Popular American ﬁlms penetrate nearly every aspect of contemporaryWestern life, and to
an only somewhat lesser degreemost all cultures of the world. Historically, there are powerful
sociological, cultural, economic, and even political reasons for this, but we would also argue
thatHollywood-style ﬁlmhas evolved so that ﬁlmmakers havemore control over the attention
of ﬁlmgoers (Smith 2006) and, in essence, the humanmind. One source of evidence concerns
the changing pattern of shot lengths.